Antiparasitic and antimicrobial activity of Ipomoea palmata against Toxoplasma gondii and Staphylococcus aureus : correlation with major phenolics identified by HPLC DOI Creative Commons
Amira Mira,

Tariq M. Aljarba,

Fatma M. Abdel Bar

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2025, Volume and Issue: 53(1), P. 194 - 206

Published: April 26, 2025

Toxoplasma gondii, a protozoan parasite found in water sources, causes toxoplasmosis, with no current protocols for inactivating its oocysts water. Staphylococcus aureus, significant bacterial pathogen, is known causing various illnesses, including skin infections and biofilm-related diseases. This study investigated the antibacterial antiparasitic properties of Ipomoea palmata leaf extract, rich phenolics, against T. gondii tachyzoites S. aureus. I. extract significantly reduced count peritoneal fluids liver smears infected mice alleviation toxoplasmosis-induced hepatitis. SEM showed surface irregularities from treated groups. The demonstrated action aureus minimum inhibitory concentration 128 to 512 µg/mL, biofilm formation 69.23% 15.38% tested isolates, downregulated genes (cna, fnbA, ica) 53.85% isolates. Treatment improved architecture, inflammation, eliminated blood vessel congestion. main phenolic acids identified by HPLC/UV analysis were chlorogenic acid, gallic ellagic methyl gallate, while predominant flavonoids apigenin, quercetin, naringenin. These findings highlight potential as natural antimicrobial agent, warranting further research isolate evaluate active compounds.

Language: Английский

Combined impact of biosynthesized selenium nanoparticles and imipenem against carbapenem-resistant Pseudomonas aeruginosa and their associated virulence factors DOI Creative Commons
Mohamed Shawky, Mohamed H. Kalaba, Gamal M. El-Sherbiny

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Language: Английский

Citations

0
Antiparasitic and antimicrobial activity of Ipomoea palmata against Toxoplasma gondii and Staphylococcus aureus : correlation with major phenolics identified by HPLC DOI Creative Commons
Amira Mira,

Tariq M. Aljarba,

Fatma M. Abdel Bar

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2025, Volume and Issue: 53(1), P. 194 - 206

Published: April 26, 2025

Toxoplasma gondii, a protozoan parasite found in water sources, causes toxoplasmosis, with no current protocols for inactivating its oocysts water. Staphylococcus aureus, significant bacterial pathogen, is known causing various illnesses, including skin infections and biofilm-related diseases. This study investigated the antibacterial antiparasitic properties of Ipomoea palmata leaf extract, rich phenolics, against T. gondii tachyzoites S. aureus. I. extract significantly reduced count peritoneal fluids liver smears infected mice alleviation toxoplasmosis-induced hepatitis. SEM showed surface irregularities from treated groups. The demonstrated action aureus minimum inhibitory concentration 128 to 512 µg/mL, biofilm formation 69.23% 15.38% tested isolates, downregulated genes (cna, fnbA, ica) 53.85% isolates. Treatment improved architecture, inflammation, eliminated blood vessel congestion. main phenolic acids identified by HPLC/UV analysis were chlorogenic acid, gallic ellagic methyl gallate, while predominant flavonoids apigenin, quercetin, naringenin. These findings highlight potential as natural antimicrobial agent, warranting further research isolate evaluate active compounds.

Language: Английский

Citations

0