Can Vitamin C Intake and Physical Activity Individually and Jointly Lower Inflammation in Chronically Infected Populations? Insights from NHANES 2005–2018 DOI
Hong Zhou, Hui Zhang,

Yaxin Huang

et al.

Published: May 13, 2025

Abstract Background: Systemic immune-inflammation is a key contributor to chronic disease pathogenesis. Whether vitamin C intake and physical activity influence inflammatory status in individuals with latent viral infections remains unclear. Methods: We conducted cross-sectional analysis of 33,590 U.S. adults from NHANES 2005–2018. Vitamin was assessed by two 24-hour dietary recalls; self-reported. The primary outcome the systemic index (SII), secondary outcomes including NLR, PLR, PPN, PC, NC, LC. Multivariable linear regression models adjusted for sociodemographic behavioral covariates. Analyses were stratified serostatus hepatitis viruses, HIV, HPV, HSV. Results: Higher associated lower SII, particularly among HSV-seropositive seronegative individuals. Moderate/vigorous independently markers these same subgroups. Joint exposure high higher showed most consistent anti-inflammatory profiles. Conclusions: jointly inflammation, pronounced effects those HSV infection or no exposure. These findings support role lifestyle modification mitigating populations immune activation.

Language: Английский

Can Vitamin C Intake and Physical Activity Individually and Jointly Lower Inflammation in Chronically Infected Populations? Insights from NHANES 2005–2018 DOI
Hong Zhou, Hui Zhang,

Yaxin Huang

et al.

Published: May 13, 2025

Abstract Background: Systemic immune-inflammation is a key contributor to chronic disease pathogenesis. Whether vitamin C intake and physical activity influence inflammatory status in individuals with latent viral infections remains unclear. Methods: We conducted cross-sectional analysis of 33,590 U.S. adults from NHANES 2005–2018. Vitamin was assessed by two 24-hour dietary recalls; self-reported. The primary outcome the systemic index (SII), secondary outcomes including NLR, PLR, PPN, PC, NC, LC. Multivariable linear regression models adjusted for sociodemographic behavioral covariates. Analyses were stratified serostatus hepatitis viruses, HIV, HPV, HSV. Results: Higher associated lower SII, particularly among HSV-seropositive seronegative individuals. Moderate/vigorous independently markers these same subgroups. Joint exposure high higher showed most consistent anti-inflammatory profiles. Conclusions: jointly inflammation, pronounced effects those HSV infection or no exposure. These findings support role lifestyle modification mitigating populations immune activation.

Language: Английский

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