Quantifying Cognitive Function in Diabetes: Relationships Between AD8 Scores, HbA1c Levels, and Other Diabetic Comorbidities

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 340 - 340

Published: Feb. 3, 2025

Background/Objectives: Dementia associated with diabetes mellitus (DM) has been well documented in the literature, but studies utilizing early screening tools to target populations mild cognitive dysfunction remain limited. This study aimed investigate decline by studying relationships between “Ascertain 8” (AD8) questionnaire scores and glycemic control, lipid profiles, estimated glomerular filtration rate (eGFR), complications of diabetes. Methods: case–control, cross-sectional, observational was conducted at a medical center an affiliated regional hospital southern Taiwan from 30 June 2021 2023. Patients diagnosed type 2 aged ≥40 years were recruited. Their past history, biochemical data, AD8 score collected same time. Results: The patients glycated hemoglobin (HbA1c) levels ≥7% had higher risk impairment than those HbA1c <7% (p < 0.001). participants whose eGFR <60 mL/min/1.73 m2 mean compared ≥60 = 0.008). history peripheral artery disease diabetic neuropathy also 0.001 p 0.017, respectively). Conclusions: By employing as sensitive tool, our suggests that is significantly poorer lower rate, disease, neuropathy. Early detection these factors may facilitate timely interventions tailored treatment strategies treat or prevent dysfunction.

Language: Английский

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Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106877 - 106877

Published: March 1, 2025

Language: Английский

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Methylglyoxal-Induced Neuronal Dysfunction: Linking Diabetes to Alzheimer's Disease through Cytoskeletal Disruption

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177526 - 177526

Published: March 1, 2025

Language: Английский

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Association between catheter ablation and psychiatric disorder risk in adults with atrial fibrillation: a multi-institutional retrospective cohort study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Background Given that atrial fibrillation (AF) s associated with a high risk of psychiatric disorders, understanding the potential benefits catheter ablation is clinically significant. This study was conducted to examine whether can prevent disorders in patients AF. Methods A retrospective cohort over two years using data from TriNetX electronic health record network. The included adults diagnosed AF and treated either antiarrhythmic or rate-control medications. Participants were divided into groups: those who underwent control group without ablation. primary outcome measured composite anxiety, depression, insomnia occurrence within one three post-treatment. Secondary outcomes individual suicidal ideation attempts, dementia, cerebral infarction, atopic dermatitis (as negative control). Results We 21,019 each matched group. demonstrated lower combined (hazard ratio(HR):0.873, 95% confidence interval (CI) 0.784–0.973, p&lt;0.01), secondary including anxiety (HR:0.822, CI:0.700–0.964; p=0.016), depression (HR:0.614, CI:0.508–0.743; p&lt;0.001), attempts (HR:0.392, CI:0.165–0.934; p=0.028), dementia (HR:0.569, CI:0.422–0.767; infarction (HR:0.704, CI:0.622–0.797; p&lt;0.001) compared non-ablation Conclusions In fibrillation, reduced developing insomnia, attempt, comparison did not undergo Clinicians should consider incorporating factors their comprehensive patient assessment when evaluating candidates for

Language: Английский

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Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 242

Published: Jan. 1, 2025

Language: Английский

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