The World Journal of Men s Health,
Journal Year:
2025,
Volume and Issue:
43
Published: Jan. 1, 2025
Environmental
endocrine
disruptors,
as
exogenous
chemicals
that
interfere
with
hormonal
behavior,
are
known
to
cause
testicular
Leydig
cell
death
and
senescence.
The
incidence
of
diseases
the
male
reproductive
system
has
been
increasing
over
past
half-century.
Genetic
defects
alone
cannot
explain
rapid
increase
in
incidence,
there
is
growing
evidence
environmental
factors
or
lifestyle
changes
responsible
for
high
recent
years.
Testicular
cells
occupy
an
important
role
system.
In
this
study,
we
review
mechanisms
by
which
disruptors
promote
both
senescence
cells,
refine
former
into
two
programmed
modes,
apoptosis,
autophagy,
further
explore
interactions
among
them,
thus
summarizing
advances
toxic
effects
on
expecting
provide
a
new
therapeutic
idea.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(2), P. 301 - 301
Published: Feb. 15, 2023
Cyclophosphamide
(CP)
is
a
cytotoxic,
cell
cycle,
non-specific,
and
antiproliferative
drug.
This
study
aimed
to
address
the
toxic
effects
of
CP
on
male
fertility
possible
ameliorative
role
hesperidin
(HSP).
Thirty-two
adult
albino
rats
were
randomly
divided
into
four
groups,
namely,
negative
control,
HSP,
CP-treated,
CP+HSP-treated
groups.
The
CP-treated
showed
significant
reduction
in
levels
serum
LH,
FSH,
testosterone,
prolactin,
testicular
glutathione
peroxidase
(GPx),
total
antioxidant
capacity
(TAC)
with
an
elevation
malondialdehyde
(MDA),
p53,
iNOS
immune
expression,
compared
control
group.
A
downregulation
hypothalamic
KISS-1,
KISS-1r,
GnRH,
hypophyseal
GnRHr,
mRNA
expression
steroidogenesis
enzymes,
PGC-1α,
PPAR-1,
IL10,
GLP-1,
as
well
upregulation
P53
IL1β
detected
group
comparison
that
administration
HSP
significantly
improved
GPx,
TAC,
MDA,
CYP19A1
In
conclusion,
could
be
potential
auxiliary
agent
for
protection
from
development
infertility.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
155, P. 113763 - 113763
Published: Sept. 28, 2022
Patients
with
diabetes
mellitus
often
suffer
from
chronic
wounds
due
to
wound
healing
impairment.
Considering
the
increased
prevalence
of
diabetes,
this
would
predispose
significant
medical,
economic,
and
social
problems.
These
are
frequently
infected
pathogenic
bacteria
like
Pseudomonas
aeruginosa,
which
complicates
situation
makes
process
more
difficult.
Therefore,
there
is
a
high
need
for
therapeutic
alternatives
currently
available
treatments.
Plants
vital
sources
many
bioactive
compounds
multiple
biological
activities.
We
elucidated
possibility
antibacterial
effect
Cycas
thouarsii
n-butanol
fraction
(CTBF)
first
time.
Also,
CTBF's
phytochemical
fingerprint
was
investigated
using
LC-MS/MS
technology.
Interestingly,
CTBF
revealed
activity
against
P.
aeruginosa
isolates
minimum
inhibitory
concentrations
range
16-128
µg/mL.
Regarding
potential,
we
used
in
vivo
experiment
on
diabetic
rats.
Remarkably
caused
reduction
(p
0.05)
levels
forkhead
box
O1,
matrix
metalloproteinases
9,
chemokine
(C-C
motif)
ligand
20.
Additionally,
it
led
substantial
increase
level
transforming
growth
factor
β1.
Moreover,
improved
histological
features
by
increasing
collagen
area
percentage.
immunohistochemical
studies,
resulted
strong
positive
epidermal
moderate
caspase
9
immunoreaction
epidermis
sebaceous
glands
wounds.
could
be
promising
source
Finally,
molecular
docking
attempted
MOE
software
investigate
binding
mode
major
identified
metalloproteinase
(MMP-9)
receptor
(PDB
code:
1GKC).
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 115095 - 115095
Published: July 4, 2023
One
of
the
most
significant
chemotherapeutic
side
effects
cisplatin
(Cis)
that
limits
its
use
and
efficacy
is
testicular
toxicity.
Thus,
objective
present
study
was
to
investigate
possible
ameliorative
effect
Fenofibrate
(Fen),
Diosmetin
(D),
their
combination
against
cis-mediated
damage.
Fifty-four
adult
male
albino
rats
were
randomly
allocated
into
nine
groups
(6
each):
Control
group,
Fen
(100
mg/kg),
D20
(20
D40
(40
Cis
group
(7
+Fen
mg/kg+100
Cis+D20
mg/kg+20
Cis+D40
mg/kg+40
Cis+Fen+D40
treated
mg/kg).
Relative
weight,
epididymal
sperm
count
viability,
serum
testosterone
level,
oxidative
stress
indices,
mRNA
expression
peroxisome
proliferator-activated
receptor
alpha
(PPAR-α),
nuclear
factor
erythroid
2-related
2
(Nrf2)
heme
oxygenase
1
(HO-1),
histopathological,
immunohistochemical
alterations
assessed.
Our
results
revealed
cis
administration
induced
inflammatory
damage
as
indicated
by
a
substantial
reduction
in
relative
parameters,
levels,
antioxidant
enzyme
activity
catalase,
Johnson's
histopathological
score,
PPAR-α/NRF-2/HO-1
proliferating
cell
antigen
(PCNA)
immunoexpression
with
marked
increment
malondialdehyde
(MDA),
Cosentino's
kappa
B
(NF-κβ
p65),
interleukin
(IL)−
1β
caspase
3
tissue.
Interestingly,
D
diminished
harmful
on
testes
via
upregulation
activities
downregulation
lipid
peroxidation,
apoptosis,
inflammation.
Moreover,
therapy
Fen/D40
also
exhibited
more
pronounced
enhancement
previous
markers
than
either
treatment
alone.
In
conclusion,
because
antioxidant,
anti-inflammatory,
anti-apoptotic
properties,
cotreatment
or
could
be
beneficial
reducing
impacts
tissue,
particularly
patients
receive
chemotherapy.
PubMed,
Journal Year:
2023,
Volume and Issue:
26(10), P. 1227 - 1236
Published: Jan. 1, 2023
In
the
present
study,
it
was
evaluated
whether
morin
has
a
protective
effect
on
testicular
toxicity
caused
by
ifosfamide
(IFOS),
which
is
used
in
treatment
of
various
malignancies.For
this
purpose,
100
or
200
mg/kg
given
to
Sprague
Dawley
rats
for
2
days,
and
single
dose
(500
mg/kg)
IFOS
administered
2nd
day.
At
24th
hr
administration,
animals
were
decapitated
tissues
taken
status
oxidative
stress,
inflammation,
endoplasmic
reticulum
stress
(ERS),
autophagy,
apoptosis
markers
analyzed
biochemical,
molecular,
histopathological
methods.According
data
obtained,
determined
that
tissues.
It
observed
ERS,
apoptosis,
DNA
damage
occurred
with
stress.
Morin
suppressed
showed
anti-inflammatory
effects
reducing
TNF-α
IL-1β
protein
levels.
also
increased
mRNA
transcript
levels
ERS
marker
ATF-6,
PERK,
IRE1,
GRP-78,
CHOP
genes,
genes
Bax,
Casp-3,
apaf-1.
up-regulated
anti-apoptotic
Bcl-2
gene
cell
survival
signal
AKT-2
gene.
decrease
beclin-1
an
anti-autophagic
effect.
addition,
attenuated
decreased
8-OHdG
immune-positive
numbers.As
result,
cellular
activating
signaling
pathways
tissue,
while
exhibited
properties
against
damage.
Düzce Tıp Fakültesi Dergisi,
Journal Year:
2025,
Volume and Issue:
Early Access
Published: April 22, 2025
Aim:
Cisplatin,
one
of
the
effective
chemotherapeutics
in
cancer
treatment,
has
potential
to
affect
testis
and
ovary,
leading
permanent
or
temporary
infertility.
This
study
aimed
determine
acute
effects
cisplatin
on
ovary
histology
investigate
whether
it
induces
any
changes
immunohistochemical
cyclooxygenase-2
(COX2),
nuclear
factor
kappa
B
p65
(NFκB-p65),
heat-shock
protein
70
(HSP70)
levels.
Material
Methods:
The
was
planned
as
four
groups:
male
control,
cisplatin,
female
cisplatin.
group
rats
were
adminestered
with
7
mg/kg
all
sacrificed
24
hours
later.
Hematoxylin-eosin
Masson's
trichrome
stains
applied
tissues
examine
their
histopathological
structure,
an
immunohistochemistry
staining
protocol
immunostaining
intensity
COX2,
NFκB-p65,
HSP70.
Results:
In
group,
a
decrease
seminiferous
tubule
epithelium,
elevation
fibrotic
response
interstitial
area,
notable
reduction
Johnson
testicular
biopsy
score
(p
