Transplantology, Journal Year: 2024, Volume and Issue: 5(3), P. 224 - 233

Published: Sept. 18, 2024

Sodium glucose cotransporter type 2 inhibitors are a new class of drugs that act on the cardiovascular system, kidneys and metabolism in multiple ways. Indeed, even though their principal action involves transport sodium convoluted distal tubule, they have actions, such as antifibrotic endothelial protective effects. Their mechanism consists loss glucose. Therefore, affect blood pressure metabolism. first use was diabetic general population; later, some studies documented activity nondiabetic population heart failure chronic kidney disease patients. Only recent years several small efficacy these transplant patients; relatively large rare, very recent, open routes for development drugs.

Language: Английский