Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 300 - 300
Published: Feb. 21, 2024
Wounds,
which
are
becoming
more
common
as
a
result
of
traumas,
surgery,
burns,
and
chronic
illnesses
like
diabetes,
remain
critical
medical
problem.
Infectious
bacteria
impact
the
healing
process,
particularly
if
its
biofilm
(biological
films)
leads
to
prolonged
effect.
Nanomaterials
have
emerged
promising
candidates
in
field
wound
due
their
unique
properties
versatile
applications.
New
insights
into
interactions
between
nanomaterials
microenvironments
shed
light
on
mechanisms
underlying
therapeutic
effects.
However,
significantly
minimal
amount
research
has
been
carried
out
see
these
promote
process.
In
this
review,
we
provided
an
outline
various
types
that
studied
for
wounds
infection
prevention.
Overall,
utilization
holds
great
promise
continues
evolve,
providing
new
opportunities
development
effective
efficient
care
therapies.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2584 - 2584
Published: May 31, 2024
There
is
a
myriad
of
diseases
that
plague
the
world
ranging
from
infectious,
cancer
and
other
chronic
with
varying
interventions.
However,
dynamism
causative
agents
infectious
incessant
mutations
accompanying
forms
like
cancer,
have
worsened
treatment
outcomes.
These
factors
often
lead
to
failure
via
different
drug
resistance
mechanisms.
More
so,
cost
developing
newer
drugs
huge.
This
underscores
need
for
paradigm
shift
in
delivery
approach
order
achieve
desired
intensified
research
nanomedicine,
which
has
shown
promises
improving
therapeutic
outcome
at
preclinical
stages
increased
efficacy
reduced
toxicity.
Regardless
huge
benefits
nanotechnology
delivery,
challenges
such
as
regulatory
approval,
scalability,
implication
potential
toxicity
must
be
addressed
streamlining
hurdles
funding.
In
conclusion,
idea
holds
immense
promise
optimizing
work
presents
opportunities
revolutionize
strategies,
providing
expert
opinions
on
translating
amount
nanomedicine
into
clinical
patients
resistant
infections
cancer.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(2), P. 207 - 207
Published: Feb. 18, 2025
The
rapid
rise
of
antibiotic
resistance
has
become
a
global
health
crisis,
necessitating
the
development
innovative
strategies
to
combat
multidrug-resistant
(MDR)
pathogens.
Nanomaterials
have
emerged
as
promising
tools
in
this
fight,
offering
unique
physicochemical
properties
that
enhance
efficacy,
overcome
mechanisms,
and
provide
alternative
therapeutic
approaches.
This
review
explores
diverse
nanomaterial-based
used
resistance,
focusing
on
their
mechanisms
action
practical
applications.
such
metal
nanoparticles,
carbon-based
nanomaterials,
polymeric
nanostructures
exhibit
antibacterial
through
various
pathways,
including
generation
reactive
oxygen
species
(ROS),
disruption
bacterial
membranes,
enhancement
delivery.
Additionally,
ability
nanomaterials
bypass
traditional
biofilm
formation
efflux
pumps,
been
demonstrated
numerous
studies.
also
discusses
synergistic
effects
observed
when
are
combined
with
conventional
antibiotics,
leading
increased
susceptibility
reduced
required
dosages.
By
highlighting
recent
advancements
clinical
applications
nanomaterial-antibiotic
combinations,
paper
provides
comprehensive
overview
how
reshaping
future
therapies.
Future
research
directions
challenges,
toxicity
scalability,
addressed
guide
safer,
more
effective
treatments.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(8), P. 1912 - 1912
Published: July 27, 2023
The
global
burden
of
bacterial
resistance
remains
one
the
most
serious
public
health
concerns.
Infections
caused
by
multidrug-resistant
(MDR)
bacteria
in
critically
ill
patients
require
immediate
empirical
treatment,
which
may
not
only
be
ineffective
due
to
MDR
multiple
classes
antibiotics,
but
also
contribute
selection
and
spread
antimicrobial
resistance.
Both
WHO
ECDC
consider
carbapenem-resistant
Enterobacteriaceae
(CRE),
Pseudomonas
aeruginosa
(CRPA),
Acinetobacter
baumannii
(CRAB)
highest
priority.
ability
form
biofilm
acquisition
drug
genes,
particular
carbapenems,
have
made
these
pathogens
particularly
difficult
treat.
They
are
a
growing
cause
healthcare-associated
infections
significant
threat
health,
associated
with
high
mortality
rate.
Moreover,
co-colonization
was
found
predictor
for
in-hospital
mortality.
Importantly,
they
potential
using
mobile
genetic
elements.
Given
current
situation,
it
is
clear
that
finding
new
ways
combat
can
no
longer
delayed.
aim
this
review
evaluate
literature
on
how
AMR.
highlights
importance
rational
use
antibiotics
need
implement
stewardship
principles
prevent
transmission
drug-resistant
organisms
healthcare
settings.
Finally,
discusses
advantages
limitations
alternative
therapies
treatment
“titans”
antibiotic
Advanced Industrial and Engineering Polymer Research,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 1, 2023
Recent
developments
in
nanomaterials
have
come
to
extensive
use
various
fields,
especially
the
biomedical
industry.
Numerous
significant
obstacles
still
need
be
overcome,
particularly
those
about
utilizing
science,
before
they
can
used
for
medicinal
purposes.
Major
issues
biomedicine
include
biological
functioning,
harmony,
toxic
effects,
and
nano-bio
surface
properties.
Thus,
researchers
may
cutting-edge
characterization
approaches
study
applications.
Two-dimensional
polymers
are
crucial
components
of
systems.
Polymer-based
flexible
more
resistant
chemical
attack
than
other
NPs.
Polymers
easily
form
composite
or
functionalization
with
NPs
improve
their
performance
compared
traditional
The
current
review
article
discussed
nanomaterial
performance,
including
carbon
nanotubes
(CNTs),
graphene,
MXene
polymers-based
state
area
is
illustrated
this
summary
article,
along
applications
significance
approaches.
advanced
methods
examining
interior
geometry,
structure,
morphology
piece
writing,
Transmission
electron
microscopy
(TEM),
Scanning
electronic
(SEM),
Atomic
Force
Microscopy
(AFM),
Magnetic
resonance
force
(MRFM)
X-ray
diffraction
(XRD).
Finally,
authors
associated
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9375 - 9375
Published: May 27, 2023
The
rapid
development
of
antimicrobial
resistance
due
to
broad
antibiotic
utilisation
in
the
healthcare
and
food
industries
non-availability
novel
antibiotics
represents
one
most
critical
public
health
issues
worldwide.
Current
advances
nanotechnology
allow
new
materials
address
drug-resistant
bacterial
infections
specific,
focused,
biologically
safe
ways.
unique
physicochemical
properties,
biocompatibility,
wide
range
adaptability
nanomaterials
that
exhibit
photothermal
capability
can
be
employed
develop
next
generation
photothermally
induced
controllable
hyperthermia
as
antibacterial
nanoplatforms.
Here,
we
review
current
state
art
different
functional
classes
strategies
optimise
efficiency.
recent
achievements
trends
developing
active
nanostructures,
including
plasmonic
metals,
semiconductors,
carbon-based
organic
polymers,
mechanisms
action,
anti-multidrug-resistant
bacteria
biofilm
removal,
will
discussed.
Insights
into
effect
various
factors
influencing
performance,
emphasising
structure-performance
relationship,
are
We
examine
agents'
functionalisation
for
specific
bacteria,
effects
near-infrared
light
irradiation
spectrum,
multimodal
synergistic-based
therapies
minimise
side
maintain
low
costs.
relevant
applications
presented,
such
antibiofilm
formation,
penetration
or
ablation,
nanomaterial-based
infected
wound
therapy.
Practical
employing
agents,
alone
synergistic
combination
with
other
nanomaterials,
considered.
Existing
challenges
limitations
therapy
future
perspectives
presented
from
structural,
functional,
safety,
clinical
potential
points
view.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(39), P. 35442 - 35451
Published: Sept. 22, 2023
The
continued
emergence
and
spread
of
drug-resistant
pathogens
the
decline
in
approval
new
antimicrobial
drugs
pose
a
major
threat
to
managing
infectious
diseases,
resulting
high
morbidity
mortality.
Even
though
significant
variety
antibiotics
can
effectively
cure
many
bacterial
microbial
infections
remain
one
biggest
global
health
problems,
which
may
be
due
traditional
drug
delivery
system's
shortcomings
lead
poor
therapeutic
index,
low
absorption,
numerous
other
drawbacks.
Further,
use
treat
diseases
has
always
been
accompanied
by
multidrug
resistance
adverse
side
effects.
Despite
developing
antibiotics,
nanomaterials,
various
techniques
combat
they
have
persisted
as
issues.
Improving
current
antibiotic
systems
is
promising
approach
solving
life-threatening
infections.
In
this
context,
nanoliposomal
recently
attracted
much
attention.
Herein,
we
attempt
provide
concise
summary
recent
studies
that
used
liposomal
nanoparticles
for
antibacterial
medicines.
minireview
also
highlights
enormous
potential
systems.
future
these
approaches
lies
more
efficient
precisely
targeting
cells
with
minimum
cytotoxicity
combating
efficacy.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(2), P. 121 - 121
Published: Jan. 25, 2024
The
development
of
antimicrobial
resistance
(AMR),
along
with
the
relative
reduction
in
production
new
antimicrobials,
significantly
limits
therapeutic
options
infectious
diseases.
Thus,
novel
treatments,
especially
current
era,
where
AMR
is
increasing,
are
urgently
needed.
There
several
ongoing
studies
on
non-classical
therapies
for
diseases,
such
as
bacteriophages,
peptides,
and
nanotechnology,
among
others.
Nanomaterials
involve
materials
nanoscale
that
could
be
used
diagnosis,
treatment,
prevention
This
review
provides
an
overview
applications
nanotechnology
diagnosis
treatment
diseases
from
a
clinician’s
perspective,
focus
pathogens
AMR.
Applications
nanomaterials
by
taking
advantage
their
electrochemical,
optic,
magnetic,
fluorescent
properties,
described.
Moreover,
potential
metallic
or
organic
nanoparticles
(NPs)
infections
also
addressed.
Finally,
use
NPs
safe
efficient
vaccines
reviewed.
Further
needed
to
prove
safety
efficacy
would
facilitate
approval
regulatory
authorities
clinical
use.
