The Neglected Sibling: NLRP2 Inflammasome in the Nervous System DOI Open Access
László Ducza, Botond Gaál

Published: Nov. 14, 2023

While classical NOD-like receptor pyrin domain containing protein 1 (NLRP1) and NLRP3 inflammasomal proteins have been extensively investigated, the contribution of NLRP2 is still ill-defined in nervous system. Given putative significance orchestrating neuroinflammation, further inquiry needed to gain a better understanding its connectome, hence specific targeting may hold promising therapeutic implication. Therefore, bioinformatical approach for extracting information, specifically context neuropathologies, also undoubtedly preferred. To best our knowledge, there no review study selectively only NLRP2. Increasing, but fragmentary evidence should encourage researchers thoroughly investigate this inflammasome various animal- human models. Taken together, herein we aimed current literature focusing on role system more importantly, provide an algorythm-based network elucidating potentially valuable molecular partnerships.

Language: Английский

Early divergent modulation of NLRP2′s and NLRP3′s inflammasome sensors vs. AIM2′s one by signals from Aβ•Calcium-sensing receptor complexes in human astrocytes DOI Creative Commons
Anna Chiarini, Ubaldo Armato, Li Gui

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1846, P. 149283 - 149283

Published: Oct. 18, 2024

Language: Английский

Citations

0
The effect of bitter honey against cerebral malaria-induced inflammasome cell death: network pharmacology-based in silico evaluation DOI

M.O. Daniyan,

Adeoye Bayo Olufunso, Esthinsheen Osirim

et al.

Biomeditsinskaya Khimiya, Journal Year: 2024, Volume and Issue: 70(6), P. 442 - 455

Published: Jan. 1, 2024

Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. The biological and physiological links between CM, inflammation, inflammasome, point to the complexity its pathology. Resistance available affordable drugs, worsening economic crisis, urgent need for integration orthodox with traditional/alternative medicine, actualized search sustainable pharmacotherapy. Previous works from our team on medicinal properties bitter honey have established botanical bioactive markers, inhibitory effects pancreatic alpha-amylase activity, anti-dyslipidemia, cardio-protective, ameliorative hepatorenal damage in streptozotocin-induced diabetic rats. In this study, we identified (BH) derived phytochemicals using gas chromatography coupled mass spectrometry (GC-MS), 9 targets genes associated BH phytochemicals. Network analysis revealed significant functional physical interactions among these NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3). Molecular docking honey-derived against most promising phytochemical candidates further experimental validation. Based results, predict that may aid suppression CM-mediated inflammasome cell death via targets.

Language: Английский

Citations

0
The Neglected Sibling: NLRP2 Inflammasome in the Nervous System DOI Open Access
László Ducza, Botond Gaál

Published: Nov. 14, 2023

While classical NOD-like receptor pyrin domain containing protein 1 (NLRP1) and NLRP3 inflammasomal proteins have been extensively investigated, the contribution of NLRP2 is still ill-defined in nervous system. Given putative significance orchestrating neuroinflammation, further inquiry needed to gain a better understanding its connectome, hence specific targeting may hold promising therapeutic implication. Therefore, bioinformatical approach for extracting information, specifically context neuropathologies, also undoubtedly preferred. To best our knowledge, there no review study selectively only NLRP2. Increasing, but fragmentary evidence should encourage researchers thoroughly investigate this inflammasome various animal- human models. Taken together, herein we aimed current literature focusing on role system more importantly, provide an algorythm-based network elucidating potentially valuable molecular partnerships.

Language: Английский

Citations

1