Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(8), P. 2136 - 2136
Published: July 28, 2023
Pathomechanisms
responsible
for
recovery
from
acute
myocarditis
(MCD)
or
progression
to
non-ischemic
cardiomyopathy
have
not
been
comprehensively
investigated.
Iron,
positioned
at
the
crossroads
of
inflammation
and
energy
metabolism
cardiomyocytes,
may
contribute
pathophysiology
inflammatory
myocardial
disease.
The
aim
this
study
was
evaluate
whether
systemic
iron
parameters
are
related
dysfunction
in
MCD
patients.
We
prospectively
enrolled
42
consecutive
patients
hospitalized
MCD.
Their
status
their
clinical,
laboratory,
echocardiographic
indices
were
assessed
during
hospitalization
ambulatory
visits
six
weeks
after
discharge.
A
control
group
comprising
healthy
volunteers
recruited.
had
higher
serum
ferritin
hepcidin
lower
concentration
transferrin
saturation
(TSAT)
than
controls
(all
p
<
0.01).
Six
discharge,
already
comparable
that
group.
During
hospitalization,
TSAT
correlated
with
NT-proBNP
(both
0.05).
In-hospital
both
a
left
ventricular
ejection
fraction
(LVEF)
worse
global
longitudinal
strain
follow-up
In
conclusion,
MCD,
is
altered
normalizes
within
weeks.
Low
greater
in-hospital
neurohormonal
activation
subtle
persistent
dysfunction.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2667 - 2667
Published: Feb. 25, 2024
Mitochondrial
dysfunction,
a
feature
of
heart
failure,
leads
to
progressive
decline
in
bioenergetic
reserve
capacity,
consisting
shift
energy
production
from
mitochondrial
fatty
acid
oxidation
glycolytic
pathways.
This
adaptive
process
cardiomyocytes
does
not
represent
an
effective
strategy
increase
the
supply
and
restore
homeostasis
thus
contributing
vicious
circle
disease
progression.
The
increased
oxidative
stress
causes
cardiomyocyte
apoptosis,
dysregulation
calcium
homeostasis,
damage
proteins
lipids,
leakage
DNA,
inflammatory
responses,
finally
stimulating
different
signaling
pathways
which
lead
cardiac
remodeling
failure.
Furthermore,
parallel
neurohormonal
with
angiotensin
II,
endothelin-1,
sympatho-adrenergic
overactivation,
occurs
stimulates
ventricular
hypertrophy
aggravates
cellular
damage.
In
this
review,
we
will
discuss
pathophysiological
mechanisms
related
are
mainly
dependent
on
perturbation
dynamics
membrane
potential
associated
failure
development
We
also
provide
overview
implication
mitochondria
as
attractive
therapeutic
target
management
recovery
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
168, P. 115674 - 115674
Published: Oct. 7, 2023
Sepsis,
the
foremost
contributor
to
mortality
in
intensive
care
unit
patients,
arises
from
an
uncontrolled
systemic
response
invading
infections,
resulting
extensive
harm
across
multiple
organs
and
systems.
Recently,
S100A8/A9
has
emerged
as
a
promising
biomarker
for
sepsis
sepsis-induced
organ
injury,
targeting
appeared
ameliorate
inflammation-induced
tissue
damage
improve
adverse
outcomes.
S100A8/A9,
calcium-binding
heterodimer
mainly
found
neutrophils
monocytes,
serves
causative
molecule
with
pro-inflammatory
immunosuppressive
properties,
which
are
vital
pathogenesis
of
sepsis.
Therefore,
improving
our
comprehension
how
acts
pathological
player
development
is
imperative
advancing
research
on
Our
review
first-to
best
knowledge-to
discuss
biology
its
release
mechanisms,
summarize
recent
advances
concerning
roles
consequential
damage,
underscore
potential
diagnostic
therapeutic
target
Free Radical Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
208, P. 846 - 858
Published: Sept. 29, 2023
Cardiovascular
diseases
(CVDs)
are
leading
causes
of
global
mortality;
however,
their
underlying
mechanisms
remain
unclear.
The
tumor
suppressor
factor
p53
has
been
extensively
studied
for
its
role
in
cancer
and
is
also
known
to
play
an
important
regulating
CVDs.
Abnormal
expression
levels
modifications
contribute
the
occurrence
development
Additionally,
mounting
evidence
underscores
critical
involvement
mitochondrial
dysfunction
Notably,
studies
indicate
that
abnormalities
directly
correlate
with
may
even
interact
each
other.
Encouragingly,
small
molecule
inhibitors
targeting
have
exhibited
remarkable
effects
animal
models
Moreover,
therapeutic
strategies
aimed
at
mitochondrial-related
molecules
replacement
therapy
demonstrated
advantageous
potential.
Therefore,
or
mitochondria
holds
immense
promise
as
a
pioneering
approach
combating
In
this
comprehensive
review,
we
delve
into
how
influences
dysfunction,
including
energy
metabolism,
oxidative
stress,
mitochondria-induced
apoptosis,
autophagy,
dynamics,
various
Furthermore,
summarize
discuss
potential
significance
treatment
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28921 - e28921
Published: March 29, 2024
Diabetic
cardiomyopathy
is
one
common
cardiovascular
complication
without
effective
treatments.
Dihydromyricetin
(DHY),
a
natural
dihydroflavonol
compound
extracted
from
Ampelopsis
grossedentata,
possesses
versatile
pharmacologically
important
effects.
In
our
current
research,
we
planned
to
evaluate
the
impact
and
probable
DHY
mechanisms
in
high
glucose
(HG)-induced
cardiomyocytes.
Primary
cardiomyocytes
were
pretreated
with
different
concentrations
of
(0,
20,
40,
80,
160,
320
μM)
for
various
time
1,
2,
4,
12,
24
h).
They
then
stimulated
48
h
5.5
mmol/L
normal
(NG)
33.3
(HG).
Cell
viability,
adenosine-triphosphate
(ATP)
levels,
lactate
dehydrogenase
(LDH)
release
detected.
JC-1
staining
was
employed
measure
mitochondrial
membrane
potential.
MitoSOX
dihydroethidium
(DHE)
applied
oxidative
stress
levels.
TDT
mediated
dUTP
nick
end
labeling
(TUNEL)
used
apoptotic
Expressions
calcium/calmodulin-dependent
protein
kinase
II
(CaMKII),
phospholamban
(PLB),
optic
atrophy
1
(OPA1),
dynamin-related
(DRP1),
caspase
3,
mixed
lineage
domain
like
(MLKL),
receptor
interacting
3
(RIPK3),
(RIPK1)
detected
by
immunofluorescence
and/or
Western
blot.
improved
cell
enhanced
ATP
level,
decreased
LDH
content
HG-stimulated
cardiomyocytes,
suggesting
attenuating
injury.
reduced
number
TUNEL
positive
cells,
inhibited
RIPK3
cleaved-caspase
expression,
implying
alleviated
necroptosis
diminished
monomers,
DHE
fluorescence
intensity
as
well
DRP1
expression
but
increased
aggregates
OPA1
indicating
that
attenuated
also
CaMKII
activity
suppressed
PLB
phosphorylation
oxidation
HG-induced
injury
wherein
necroptosis,
repressed
ROS
production,
oxidation,
may
serve
potential
agent
prevent
treat
diabetic
cardiomyopathy.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(3)
Published: March 1, 2025
Pulmonary
hypertension
(PH)
stands
as
a
tumor
paradigm
cardiovascular
disease
marked
by
hyperproliferation
of
cells
and
vascular
remodeling,
culminating
in
heart
failure.
Complex
genetic
epigenetic
mechanisms
collectively
contribute
to
the
disruption
pulmonary
homeostasis.
In
recent
years,
advancements
research
technology
have
identified
numerous
gene
deletions
mutations,
addition
bone
morphogenetic
protein
receptor
type
2,
that
are
closely
associated
with
remodeling
process
PH.
Additionally,
modifications
such
RNA
methylation,
DNA
histone
modification,
noncoding
RNAs
been
shown
precisely
regulate
PH
molecular
networks
cell-type-specific
manner,
emerging
potential
biomarkers
therapeutic
targets.
This
review
summarizes
analyzes
roles
currently
genes
factors
PH,
emphasizing
pivotal
role
long
ncRNAs
its
regulation.
it
examines
current
clinical
preclinical
therapies
for
targeting
these
explores
new
treatment
strategies.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Myocardial
ischemia-reperfusion
(I/R)
injury
which
leads
to
continuously
worsening
ventricular
remodeling
and
cardiac
dysfunction
in
the
chronic
stage,
is
a
significant
contributor
global
prevalence
of
heart
failure.
Traditional
Chinese
herbal
formulas
have
been
shown
prevent
myocardial
I/R
injury.
Method
This
study
aims
investigate
whether
Danqi
soft
caspule
(DQ),
classical
traditional
medicine
(TCM)
preparation,
exerted
protective
effects
against
explore
potential
underlying
mechanisms.
A
rat
model
cell
H
2
O
induced
oxidative
stress
were
established
assess
DQ
on
injury,
cardiomyocyte
apoptosis,
as
well
mitochondrial
structure
function.
Result
pre-treatment
reduced
both
proportion
infarct
area
ischemic
risk
decreased
apoptosis
rats.
In
cells,
was
found
reduce
lower
levels.
Furthermore,
inhibited
fission,
prevented
alterations
membrane
potential,
suppressed
Cytochrome
C
release
from
mitochondria,
thereby
preventing
apoptosis.
has
by
reducing
through
inhibition
fission.
Moreover,
could
restore
function
suppressing
phosphorylation
Ca
2+
/calmodulin-dependent
protein
kinase
II
(CaMKII)
dynamin-related
1
(Drp-1).
Conclusion
fission
associated
with
CaMKII
Drp-1.
Reviews in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
26(3)
Published: March 18, 2025
Pulmonary
hypertension
(PH)
is
a
life-threatening
condition
characterized
by
right
ventricular
(RV)
remodeling,
which
major
determinant
of
patient
survival.
The
progression
remodeling
significantly
influenced
mitochondrial
dysfunction,
providing
profound
insights
into
vascular
health
and
cardiovascular
risk.
In
this
review,
we
discuss
the
molecular
targets,
pathophysiological
characteristics,
potential
mechanisms
underlying
dysfunction
in
PH,
encompassing
disturbances
dynamics,
inflammation,
dysregulation
energy
metabolism.
Finally,
review
primary
therapeutic
targets
currently
utilized
to
address
cardiac
resulting
from
damage.
Hopefully,
might
inspire
novel
approaches
management
disorders.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(11), P. 4976 - 4998
Published: Aug. 2, 2023
Abstract
Cardiovascular
diseases
are
currently
the
primary
cause
of
mortality
in
whole
world.
Growing
evidence
indicated
that
disturbances
cardiac
fatty
acid
metabolism
crucial
contributors
development
cardiovascular
diseases.
The
abnormal
usually
leads
to
energy
deficit,
oxidative
stress,
excessive
apoptosis,
and
inflammation.
Targeting
has
been
regarded
as
a
novel
approach
treatment
However,
there
no
specific
drugs
regulate
treat
Many
traditional
Chinese
medicines
have
widely
used
clinics.
And
modern
studies
shown
they
exert
cardioprotective
effect
by
regulating
expression
key
proteins
involved
metabolism,
such
peroxisome
proliferator‐activated
receptor
α
carnitine
palmitoyl
transferase
1.
Hence,
we
systematically
reviewed
relationship
between
disorders
four
types
including
heart
failure,
coronary
artery
disease,
hypertrophy,
diabetic
cardiomyopathy.
In
addition,
18
extracts
eight
monomer
components
from
showed
effects
restoring
metabolism.
This
work
aims
provide
reference
for
finding
agents
targeting
