Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(7), P. 2078 - 2078

Published: July 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Language: Английский

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Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1456 - 1456

Published: Feb. 10, 2025

Dietary flavonoids are a group of polyphenol compounds originating from plants that have drawn much attention in the last few decades. Flavonoid-rich foods and dietary supplements used worldwide due to their health benefits, including antioxidative, anti-inflammatory, immunity-enhancing, anticarcinogenic, estrogenic, favorable cardiovascular effects. The main objective our study was explore molecular targets gain insight into mechanism action behind biological In this study, novel class resorcinol-based flavonoid identified as potent inhibitor human DNA ligase activity. Human ligases crucial maintenance genetic integrity cell fate determination. Thus, results strongly suggest activity against is responsible, at least part, for cellular effects compounds. We anticipate studies will improve understanding how interactions with cascade recognized benefits flavonoids, particularly wide variety anticancer

Language: Английский

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Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

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Polyphenols: Potential Applications in Cancer Therapy

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, anticancer properties. However, efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, extensive excretion. Thus, research has focused on improving delivery systems, such as, example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve and/or facilitate targeted cancer cells. promising modulating cancer-related pathways cell proliferation death, metastatic invasion, though translation patients hindered complex mechanisms. This review analyzes factors that affect PF bioavailability, evidences of vivo effects animal models mechanisms, results clinical trials, strategies enhance bioavailability. The idea need directly interact the challenged. Future aims optimize combine standard treatments, explore epigenetic effects, modulation tumor microenvironment, interactions gut microbiota. Advances personalized medicine structural modifications stability absorption could further potential. Despite challenges, remain a avenue complementary oncotherapy solutions.

Language: Английский

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Role and Function of Receptor Tyrosine Kinases in BRAF Mutant Cancers

Receptors, Journal Year: 2024, Volume and Issue: 3(1), P. 58 - 106

Published: March 4, 2024

The development of potent BRAF inhibitors has revolutionized the treatment mutant cancers, in particular, melanomas. However, cancers other entities, e.g., colorectal display distinctly reduced responses to inhibitors. In addition, emergence cancer resistance inhibitor poses a severe problem. reactivation MAPK/ERK signaling was identified as an important mode resistance. Receptor tyrosine kinases (RTKs), which are prominent anticancer drug targets their own right, play crucial role and signal transduction, well establishment bypassing pathways. MAPK can occur via increased expression RTKs, altered RTK signaling, post-translational processes, among others. This review summarizes influence pertinent RTKs on outlines possible proven ways circumvent BRAF-associated mechanisms.

Language: Английский

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Fucoxanthin: From chemical properties and sources to novel anticancer mechanistic insights and synergistic therapeutic opportunities

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100203 - 100203

Published: Jan. 1, 2024

Fucoxanthin (FX) is a carotenoid of marine origin primarily distributed in brown seaweeds and has garnered interest for its antioxidative, anti-inflammatory, anticancer properties. Despite potential, comprehensive understanding effects mechanisms action remains elusive. The aim this review to present novel insights into the FX, shedding light on previously unexplored molecular synergistic potential with established chemotherapeutic agents. A search was conducted employing databases like PubMed/MedLine, Scopus, Web Science aggregate relevant pharmacological experimental studies. results studies showed that FX exhibits activity against various cancer types, including breast, colorectal, lung cancer, through multiple pathways: cell cycle arrest, apoptosis induction, inhibition angiogenesis. Additionally, potentiates existing agents, making it candidate combination therapies. evidence suggests possesses considerable properties, acting diverse mechanisms; heterogeneity study designs limited number clinical trials make hard conclude. Further in-depth studies, particularly randomized controlled trials, are essential validating FX's efficacy paving way integration standard treatment regimens; additional research needed explore pharmacokinetics, safety profile, chemotherapeutics.

Language: Английский

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The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer

Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(12), P. 1195 - 1212

Published: Feb. 16, 2024

NADPH oxidase, as a major source of intracellular reactive oxygen species (ROS), assumes an important role in the immune response and oxidative stress body. oxidase 2 (NOX2) is first most representative member family, its effects on development tumor cells are gaining more attention. Our previous study suggested that NCF4 polymorphism p40phox, key subunit NOX2, affected outcome diffuse large B-cell lymphoma patients treated with rituximab. It hypothesized NOX2-mediated ROS could enhance cytotoxic some anti-tumor drugs favor tumors. Several reviews have summarized NOX2 congeners-mediated therapy, but few studies focused relationship between expression drug resistance. In this article, we systematically introduced NOX represented by classification latest inhibitors agonists NOX2. will help researchers to rational objective understanding dual resistance expected provide new ideas for oncology treatment overcoming cancer.

Language: Английский

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Cancer drug resistance is a serious threat in Bangladesh

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: 2(5), P. 742 - 743

Published: Jan. 30, 2024

Cancer drug resistance is a serious issue in Bangladesh that must be addressed with effective solutions. The growth of resistant bacterial strains, inappropriate use antimicrobials, and inadequate healthcare standards have resulted severe problem cancer medication resistance. A comprehensive strategy will needed to address these problems, one includes expanding knowledge antibiotic resistance, bettering system regulation, developing more potent therapies.

Language: Английский

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The Potential Role of Polyphenol Supplementation in Preventing and Managing Depression: A Review of Current Research

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1342 - 1342

Published: Oct. 21, 2024

Depression is a common mental illness that affects 5% of the adult population globally. The most symptoms depression are low mood, lack pleasure from different activities, poor concentration, and reduced energy levels for an extended period, it emotions, behaviors, overall well-being individual. complex pathophysiology presents challenges current therapeutic options involving biopsychosocial treatment plan. These treatments may have delayed onset, remission response rates, undesirable side effects. Researchers in nutrition food science increasingly addressing depression, which significant public health concern due to association with increased incidence cardiovascular diseases premature mortality. Polyphenols present our diet significantly impact prevention depression. primary mechanisms include reducing inflammation oxidative stress, regulating monoamine neurotransmitter levels, modulating microbiota-gut-brain axis hyperactivity hypothalamic-pituitary-adrenal (HPA) axis. This review summarizes recent advances understanding effects dietary polyphenols on explores underlying these benefit human health. It also highlights studies looking at clinical trials help future researchers incorporate substances into functional diets, nutritional supplements, or adjunctive therapy prevent treat

Language: Английский

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Determination of antioxidants and total polyphenols in cabbages (Brassica oleracea) irrigated with wastewater contaminated with toxic metals

Journal of Engineering Research, Journal Year: 2023, Volume and Issue: 3(35), P. 2 - 9

Published: Oct. 24, 2023

Water is a natural resource essential to all kinds of life.The reuse treated wastewater (TWW) for irrigation possibility with challenges be clarified at scientific level, in particular, its use activities due the eventual contamination vegetables, like cabbages (Brassica oleracea), by toxic metals and other compounds harmful humans present these waters.On hand, TWW vegetable may allow significant water saving also providing cultivated species nutrients, which dispense fertilizers.In this work, vegetables such as Brassica oleracea (cabbage), were planted greenhouse controlled environment (temperature humidity) located ISEL campus.Part was irrigated tap water, another part from two treatment plants (WWTP) Lisbon´s District.One WWTP receives only domestic (A), whilst one industrial (B).The antioxidant activity well total content polyphenols flavonoids plant extracts determined order assess impact using contaminated their irrigation.

Language: Английский

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