The
World
Health
Organization
declared
the
coronavirus
disease
2019
(COVID-19)
pandemic
in
2020,
following
which
a
global
genetic
vaccination
program
has
been
rapidly
implemented
as
fundamental
solution.
However,
it
reported
worldwide
that
modified
mRNAs
encoding
spike
proteins
and
lipid
nanoparticles,
are
used
drug
delivery
systems,
not
only
cause
thrombosis
cardiovascular
disorders
post
vaccination,
but
might
also
diverse
diseases
involving
all
organs
including
nervous
system.
Furthermore,
toxicity
pathogenicity
of
may
necessitate
defining
these
nonbiological
infective
material.
Based
on
reports
abundant
evidence
come
to
light
past
few
years,
this
paper
aims
draw
attention
medical
professionals
various
risks
associated
with
transfusion
using
blood
products
derived
from
long
COVID
patients
or
vaccine
recipients,
make
proposals
regarding
specific
inspection
items,
testing
methods,
regulations,
etc.
This
provides
insights
address
post-vaccination
syndrome
its
consequences
such
programs.
The
coronavirus
pandemic
was
declared
by
the
World
Health
Organization
(WHO)
in
2020,
and
a
global
genetic
vaccination
program
has
been
rapidly
implemented
as
fundamental
solution.
However,
many
countries
around
world
have
reported
that
so-called
vaccines,
such
those
using
modified
mRNA
encoding
spike
protein
lipid
nanoparticles
drug
delivery
system,
resulted
post-vaccination
thrombosis
subsequent
cardiovascular
damage,
well
wide
variety
of
diseases
involving
all
organs
systems,
including
nervous
system.
In
this
article,
based
on
these
circumstances
volume
evidence
recently
come
to
light,
we
call
attention
medical
professionals
various
risks
associated
with
blood
transfusions
products
derived
from
people
who
suffered
long
COVID
vaccine
recipients,
received
make
proposals
regarding
specific
tests,
testing
methods,
regulations
deal
risks.
We
expect
proposal
will
serve
basis
for
discussion
how
address
syndrome
its
consequences
following
programs.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4440 - 4440
Published: April 18, 2024
The
COVID-19
pandemic
prompted
rapid
research
on
SARS-CoV-2
pathogenicity.
Consequently,
new
data
can
be
used
to
advance
the
molecular
understanding
of
infection.
present
bioinformatics
study
discusses
"spikeopathy"
at
level
and
focuses
possible
post-transcriptional
regulation
spike
protein
S1
subunit
in
host
cell/tissue.
A
theoretical
protein-RNA
recognition
code
was
check
compatibility
with
mRNAs
human
transcriptome
(1-L
transcription).
principle
for
this
method
is
elucidated
defined
RNA
binding
GEMIN5
(gem
nuclear
organelle-associated
5)
RNU2-1
(U2
spliceosomal
RNA).
Using
described
here,
it
shown
that
45%
genes/proteins
identified
by
1-L
transcription
are
directly
linked
COVID-19,
39%
indirectly
16%
cannot
currently
associated
COVID-19.
stroke,
diabetes,
cardiac
injury.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(4), P. 647 - 647
Published: April 22, 2024
Consistent
with
the
biochemistry
of
coronaviruses
as
well
established
over
decades,
SARS-CoV-2
makes
its
initial
attachment
to
host
cells
through
binding
spike
protein
(SP)
sialylated
glycans
(containing
monosaccharide
sialic
acid)
on
cell
surface.
The
virus
can
then
slide
and
enter
via
ACE2.
SP
attaches
particularly
tightly
trillions
red
blood
(RBCs),
platelets
endothelial
in
human
body,
each
very
densely
coated
acid
surface
molecules
but
having
no
ACE2
or
minimal
These
interlaced
attachments
trigger
aggregation,
microvascular
occlusion
vascular
damage
that
underlie
hypoxia,
clotting
related
morbidities
severe
COVID-19.
Notably,
two
betacoronaviruses
express
a
acid-cleaving
enzyme
are
benign,
while
other
three—SARS,
MERS—are
virulent.
RBC
aggregation
experimentally
induced
several
animal
species
using
an
injected
polysaccharide
caused
most
same
This
glycan
is
key
disentangling
controversies
have
arisen
efficacy
certain
generic
COVID-19
treatment
agents
safety
SP-based
vaccines.
More
broadly,
disregard
for
active
physiological
role
RBCs
yields
unreliable
erroneous
reporting
pharmacokinetic
parameters
routinely
obtained
drugs
bioactive
detection
plasma,
whole-blood
levels
being
up
30-fold
higher.
Appreciation
elucidate
underpinnings
health
conditions,
including
cardiovascular
disease,
therapeutic
opportunities
address
them.
The
World
Health
Organization
declared
the
coronavirus
disease
2019
(COVID-19)
pandemic
in
2020,
following
which
a
global
genetic
vaccination
program
has
been
rapidly
implemented
as
fundamental
solution.
However,
it
reported
worldwide
that
modified
mRNAs
encoding
spike
proteins
and
lipid
nanoparticles,
are
used
drug
delivery
systems,
not
only
cause
thrombosis
cardiovascular
disorders
post
vaccination,
but
might
also
diverse
diseases
involving
all
organs
including
nervous
system.
Furthermore,
toxicity
pathogenicity
of
may
necessitate
defining
these
nonbiological
infective
material.
Based
on
reports
abundant
evidence
come
to
light
past
few
years,
this
paper
aims
draw
attention
medical
professionals
various
risks
associated
with
transfusion
using
blood
products
derived
from
long
COVID
patients
or
vaccine
recipients,
make
proposals
regarding
specific
inspection
items,
testing
methods,
regulations,
etc.
This
provides
insights
address
post-vaccination
syndrome
its
consequences
such
programs.
