Predictive Value of Inflammatory Biomarkers in Assessing Major Depression in Adults DOI Creative Commons
Radu Sebastian Gavril, Romeo Dobrin, Alin Constantin Pînzariu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2501 - 2501

Published: Oct. 31, 2024

There are studies that have investigated the association of pro-inflammatory cytokines with depressive disorders, but they often present certain limitations. In this study, two substantial groups patients were analyzed: 92 major disorder and 76 without disorders. The strict inclusion exclusion criteria for analyzed significantly increased value obtained results. research question study was whether levels inflammation, measured by inflammatory markers IL-6, IL-1α, TNF-α, could predict severity symptoms. This provide additional evidence supporting hypothesis inflammation plays a notable role in pathogenesis depression. data analysis supports biological mechanisms contribute to clinical manifestations Elevated markers, especially interleukins (IL-6, IL-1α) tumor necrosis factor-alpha (TNF α), been identified compared findings healthy controls.

Language: Английский

Early life stress and brain development: Neurobiological and behavioral effects of chronic stress DOI
Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Student anxiety in the wake of the COVID-19 pandemic DOI Creative Commons
Birgitta Dresp,

Ulviyya Zulfiqarova

Published: July 25, 2024

Meta-analyses of the pertaining literature have shown that generalized anxiety disorder (GAD) in youth particularly students is a prevalent syndrome mental health issues identified 2022, wake COVID-19 pandemic, by World Health Organization and other national organizations such as Santé Publique France.This study, performed between 2022 2023, offers pinhole view student post-COVID-19 context at French University.A sample population 80 undergraduate medical within age range from 18 to 24 years was tested for GAD survey using an online version Hamilton Anxiety Scale (HAM-A).The total test scores indicate prevalence severe very 36% population, which consistent with results studies on larger populations countries.Further statistical analyses reveal significantly higher number psychological symptoms comparison somatic GAD.The reasons why, under light findings placed current societal context, needs be addressed terms problem beyond immediate consequences pandemic are discussed.

Language: Английский

Citations

3
What Remains to Be Discovered in Schizophrenia Therapeutics: Contributions by Advancing the Molecular Mechanisms of Drugs for Psychosis and Schizophrenia DOI Creative Commons
Christoph U. Correll, Massimo Tusconi, Mauro Giovanni Carta

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 906 - 906

Published: July 25, 2024

Schizophrenia is a frequently debilitating and complex mental disorder affecting approximately 1% of the global population, characterized by symptoms such as hallucinations, delusions, disorganized thoughts behaviors, cognitive dysfunction, negative symptoms. Traditional treatment has centered on postsynaptic dopamine antagonists, commonly known antipsychotic drugs, which aim to alleviate improve functioning quality life. Despite availability these medications, significant challenges remain in schizophrenia therapeutics, including incomplete symptom relief, resistance, medication side effects. This opinion article explores advancements treatment, emphasizing molecular mechanisms, novel drug targets, innovative delivery methods. One promising approach strategies that target neural networks circuits rather than single neurotransmitters, acknowledging complexity brain region interconnections involved schizophrenia. Another development biased agonists, selectively activate specific signaling pathways downstream receptors, offering potential for more precise pharmacological interventions with fewer The concept polypharmacy, where targets multiple pathways, exemplified KarXT, combining xanomeline trospium address both psychosis dysfunction. represents comprehensive strategy potentially improving outcomes patients. In conclusion, advancing understanding exploring therapeutic hold promise addressing unmet needs aiming effective tailored interventions. Future research should focus approaches achieve better clinical functional level life individuals

Language: Английский

Citations

2
Capillary Electrophoresis‐Frontal Analysis (CE‐FA) and Molecular Docking Studies on the Albumin‐Binding Properties of Dopamine and Serotonin DOI
Zeynep Kalaycıoğlu,

Defne Bilen

Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(23)

Published: Dec. 1, 2024

ABSTRACT Dopamine and serotonin are neurotransmitters that crucial for numerous physiological processes, including mood regulation, reward, motor function. Dysregulation of these is associated with various neuropsychiatric disorders. Albumin in plasma modulates the bioavailability drugs free concentrations bioactive constituents. This study aimed to characterize interactions dopamine bovine serum albumin. Capillary electrophoresis frontal analysis mode was utilized as an effective method assess dopamine–bovine albumin serotonin–bovine affinity. The neurotransmitter plateaus were distinctly separated from albumin–neurotransmitter complex plateaus. Free determined by monitoring heights their respective In contrast, bound calculated difference between total plateau heights. found bind at independent sites binding constant values 1.90 × 10 3 2.90 L/mol, respectively. Additionally, silico molecular docking approach revealed near glutamic acid‐291 serine‐428 residues albumin,

Language: Английский

Citations

2
Evaluation of the Correlation Between Depression Intensity and Inflammation Levels in Patients with Major Depressive Disorder: A Case-Control Study DOI Open Access
Radu Sebastian Gavril,

Petru-Romeo Dobrin,

Vlad-Teodor Iacob

et al.

Published: July 24, 2024

The primary objective of this study is to determine the existence a significant correlation between inflammation levels, as measured by inflammatory markers IL-6, IL-1β, and TNF-α, severity depressive symptoms assessed using HAM-D assessment scale. This could provide additional evidence supporting hypothesis that plays notable role in pathogenesis depression. data analysis supports biological mechanisms contributes clinical manifestations Elevated levels markers, especially interleukins (IL6, IL1β), tumor necrosis factor-alpha (TNFα), C-reactive protein (CRP) have been identified patients with major disorder compared findings healthy controls. Materials Methods: Inflammatory (IL-6, TNF-α) were sample 31 hospitalized at Socola Institute Psychiatry Iasi, Romania, control group no psychiatric or conditions. One main objectives if there TNF-α), scores. Conclusions: results suggest IL-1β IL-6 evaluated scores group. These support may play an important development exacerbation symptoms. relationship depression also influenced risk protective factors require further research.

Language: Английский

Citations

1
How Green Space Justice in urban built-up areas affects public mental health: a moderated chain mediation model DOI Creative Commons
Dong Tian, Qikang Zhong,

Bangguo Yue

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 2, 2024

Background Green and blue spaces, as crucial components of urban ecosystems, significantly impact the physical mental health residents. However, mechanisms through which Green/Blue Space Justice influence residents’ remain unclear. Methods This study aims to explore green spaces on public psychological responses, activity, from a justice perspective, examine moderating role in this relationship. The research was conducted selected communities within Chang-Zhu-Tan agglomeration Hunan Province, China. A total 801 valid questionnaires were collected field visits online surveys. uses an improved Gaussian-based two-step floating catchment area (2SFCA) method assess space accessibility. Data analyzed using structural equation modeling (SEM) moderation effect analysis reveal relationships between variables. Results findings indicate that has significant positive health; responses activity play mediating roles affects chain mediation path involving activity. Moreover, Blue moderates but does not have direct health. Conclusion enriches theory by revealing it influences via It provides scientific basis for development healthy cities. Additionally, recommends planning should prioritize equitable distribution high accessibility both comprehensively enhance well-being. Policymakers consider prioritizing high-quality vulnerable during renewal expansion processes reduce social inequalities promote broader outcomes.

Language: Английский

Citations

1
The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework DOI Creative Commons

Esther R.-H. Lin,

Faith Nicole Veenker,

Peter Manza

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1285 - 1285

Published: Dec. 21, 2024

Substance use disorders (SUDs) and anxiety (ADs) are highly comorbid, a co-occurrence linked to worse clinical outcomes than either condition alone. While the neurobiological mechanisms involved in SUDs intensively studied separately, underlying their comorbidity remain an emerging area of interest. This narrative review explores processes this comorbidity, using Research Domain Criteria (RDoC) framework map disruptions positive valence, negative cognitive systems across three stages addiction cycle: binge/intoxication, withdrawal/negative affect, preoccupation/anticipation. Anxiety substance play reciprocal role at each stage addiction, marked by significant psychosocial impairment dysregulation brain. A more thorough understanding neural underpinnings comorbid will contribute tailored effective therapeutic interventions assessments.

Language: Английский

Citations

1
Coletânea Ludovicense de Psicologia - Volume 5 DOI Open Access

Marco Aurélio Fernandes,

Elizabeth Silva Dias,

Larissa Christine Pires Pereira

et al.

Editora Pascal LTDA eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

O presente livro possui importantes reflexões acerca dos fundamentos que permeiam os principais debates da Psicologia na contemporaneidade. Nele, autores analisam com argúcia temas emergentes conjuntura atuação profissional, protagonizando análises indispensáveis ao cotidiano do(a) psicólogo. Sabe-se a atual requer esforços numerosos no concerne produção do conhecimento rigorosidade o percurso científico pleiteia. No entanto, por se compreender imprescindibilidade papel sociabilidade indivíduos, faz-se necessário entendê-la partir de seu processo metodológico e, sua inventividade, aproximação profusos feitos psique humana e seus rebatimentos à sociedade.

Citations

0
Craving: explanatory models, associated factors, and therapeutic approaches: A systematic review DOI Creative Commons
Olena Klimenko, Oscar Zamora-Contreras, Nubia Hernández-Flórez

et al.

Psicoespacios, Journal Year: 2024, Volume and Issue: 18(33)

Published: July 11, 2024

Introduction: the diagnostic criteria of craving for substance use addition disorder was included in Diagnostic and Statistical Manual Mental Disorders DSM-5 2013. However, this remains a complex phenomenon that requires further attention. Objective: present study aimed to review explanatory models craving, describe factors involved anxiety maintaining an addictive behavior point out treatments have been proposed so far control craving. Method: systematic literature oriented according Cochrane Collaboration, 100 articles selected from keywords Boolean search engines databases Scielo, Dialnet, Scopus, PubMed, Web Science EBSCOhost. Results: represents great complexity underlying all kinds behavior, which is interpreted different such as: neurobiological, tolerance abstinence, emotional regulation, learning conditioning, information processing meeting needs. Likewise, multiple associated with are evident cognitive, emotional, social environmental aspects, forcing implementation therapeutic approaches broad range pharmacological, cognitive-behavioral innovative virtual reality mindfulness. Conclusions: contribution obliges consider integral interdisciplinary intervention prevention processes, at addressing biopsychosocial aspects optimize recovery prevent relapses both chemical behavioral addictions.Keywords: addictions, models, factors, approaches.

Language: Английский

Citations

0
Exploring Decision-Making Processes in Neuroeconomics DOI

Leema Jacob,

K. Jayasankara Reddy

Advances in finance, accounting, and economics book series, Journal Year: 2024, Volume and Issue: unknown, P. 79 - 94

Published: Sept. 13, 2024

This chapter delves into the profound neuroeconomic principles that lay foundation of health behaviors, offering a deep understanding brain mechanisms profoundly influence decision-making in health-related situations. study harmoniously blends neuroscience and behavioral economics to unravel how meticulously evaluates potential advantages disadvantages choices. employs cutting-edge neuroimaging research assessments illuminate impact networks on intricate interplay between cognitive processes, emotional responses, decision-making. The key focus areas encompass reward processing, risk perception, social variables behavior. provides invaluable insights construction impactful treatments foster healthier lifestyles reduce disparities by uncovering neural underpin

Language: Английский

Citations

0