Molecular Docking and Antihypertensive Activity of Eupalitin 3-O-β-D-galactopyranoside Isolated from Boerhavia diffusa Linn DOI Creative Commons

Ilyas Uoorakkottil,

Rashid Koottangodan,

Kamal YT

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1628 - 1628

Published: Dec. 23, 2024

Background: Angiotensin-converting enzyme (ACE) is a key regulator of blood pressure, and ACE inhibition an essential part the treatment hypertension. We used molecular docking approach to find interaction with active flavonoid isolated from Boerhavia diffusa Linn, eupalitin 3-O-β-D-galactopyranoside, which leads potential antihypertensive effects in methyl predenisolone-induced hypertensive rats. Additionally, pharmacokinetic parameters this compound are assessed. Methods:eupalitin-3-O-β-D-galactopyranoside was leaves by sedimentation method. The characterized UPLC-MSMS, NMR, UV spectroscopy confirm identity compound. Hypertension induced rats predenisolone (5 mg/kg/day) for 14 days. Systolic diastolic pressure 3-O-β-D-galactopyranoside were assessed using tail-cuff plasma data oral administration determine various bioavailability serum concentration. Results: In rats, both systolic pressures significantly lower than that vehicle (p < 0.01). Conclusions: process showed moderate compound; induces powerful activity implying clinical application as new therapeutic drug

Language: Английский

Flavonoids: Potential therapeutic agents for cardiovascular disease DOI Creative Commons
Yingxue Liu, Jing Luo, Peng Lin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32563 - e32563

Published: June 1, 2024

Flavonoids are found in the roots, stems, leaves, and fruits of many plant taxa. They related to growth development, pigment formation, protection against environmental stress. function as antioxidants exert anti-inflammatory effects cardiovascular system by modulating classical inflammatory response pathways, such TLR4-NF-ĸB, PI3K-AKT, Nrf2/HO-1 signalling pathways. There is increasing evidence for therapeutic flavonoids on hypertension, atherosclerosis, other diseases. The potential clinical value diseases has been widely explored. For example, studies have evaluated roles regulation blood pressure via endothelium-dependent non-endothelium-dependent pathways myocardial systolic diastolic functions influencing calcium homeostasis smooth muscle-related protein expression. also hypoglycaemic, hypolipidemic, anti-platelet, autophagy, antibacterial effects. In this paper, role mechanism were reviewed order provide reference application future.

Language: Английский

Citations

16
Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade DOI Creative Commons
Sujin Shin, Junkyu Park, Ho-Young Choi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 346 - 346

Published: Feb. 1, 2024

Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources hypertension treatment. Previous studies revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from

Language: Английский

Citations

5
Association between dietary flavonoid intake and hypertension among U.S. adults DOI Creative Commons
Yingying Wan, Dan Ma, Qinghua Shang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Background Hypertension is one of the major risk factors for cardiovascular disease. Dietary flavonoids have been reported to reduce inflammation, protect against oxidative stress, vascular endothelium, and improve health. However, relationship between dietary flavonoid intake prevalence hypertension remains controversial. Methods This study included 8010 adults from 2007-2010 2017-2018 National Health Nutrition Examination Surveys (NHANES). The was explored by weighted logistic regression restricted cubic spline. Results We found an inverse total anthocyanin in fourth quartile compared with first [0.81(0.66,0.99), p = 0.04]. Moreover, tended decrease increasing participants over 60 years age. In addition, we a U-shaped flavan-3-ol intake. Total inversely associated third [0.79 (0.63,0.99), there significant negative association when below 48.26 mg/day. Conclusion Our moderate anthocyanins flavan-3-ols provides evidence population-based hypertension.

Language: Английский

Citations

4
Anticancer Activity of Ether Derivatives of Chrysin DOI Creative Commons
Arkadiusz Sokal,

Patryk Mruczek,

Mateusz Niedoba

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 960 - 960

Published: Feb. 19, 2025

Chrysin, a naturally occurring flavonoid, exhibits broad spectrum of biological activities, including showing anticancer properties. However, its clinical application is limited by poor bioavailability and low solubility. The introduction an amine, amide, ester, or alkoxy group to flavone skeleton influences the activity. This review also discusses hybrid compounds, such as chrysin-porphyrin hybrid, which are characterized higher activity better properties than single molecules. concentrates on chrysin derivatives against most popular cancers, breast, lung, prostate, gastrointestinal tumors.

Language: Английский

Citations

0
Characterization of key compounds and biological screening of Salvia sclareopsis Bornm DOI

Shiva Khalil-Moghaddam,

Najibullah Hakimi,

Roya Moghimi

et al.

Chemical Papers, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Comprehensive evaluation on nutritional characteristics and anti-hyperglycemic active ingredients of different varieties of Yam DOI Creative Commons

Yu-Zheng Lin,

Li Qu,

Mengting Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Yam is a versatile economic crop that serves both medicinal and dietary purposes. Dehua County, located in Fujian Province, China, renowned as one of the major yam production areas, with cultivation history spanning over 600 years. It has successfully cultivated Qingfeng Ziyu yam, which have been recognized China's "Geographical Indications for Agricultural Products." However, no comprehensive studies conducted to evaluate their quality. This study meticulously utilized authentic material "Iron yam" benchmark, employing advanced techniques such high-performance liquid chromatography (HPLC), ultraviolet spectrophotometry, flame atomic absorption spectrometry systematically analyze nutritional hypoglycemic active components three distinct varieties. In order interpret data, descriptive statistics, correlation analysis, principal component analysis (PCA), partial least squares discriminant (PLS-DA), cluster multiple linear regression were applied. The results revealed significant variations concentrations various indicators across types. Correlation identified 65 pairs exceptionally strong correlations 39 statistically associations. Additionally, demonstrated Iron exhibited most favorable overall Notably, characterized by its high concentration compounds, emerged promising raw products, showcasing potential this field.

Language: Английский

Citations

0
Molecular Docking and Antihypertensive Activity of Eupalitin 3-O-β-D-galactopyranoside Isolated from Boerhavia diffusa Linn DOI Creative Commons

Ilyas Uoorakkottil,

Rashid Koottangodan,

Kamal YT

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1628 - 1628

Published: Dec. 23, 2024

Background: Angiotensin-converting enzyme (ACE) is a key regulator of blood pressure, and ACE inhibition an essential part the treatment hypertension. We used molecular docking approach to find interaction with active flavonoid isolated from Boerhavia diffusa Linn, eupalitin 3-O-β-D-galactopyranoside, which leads potential antihypertensive effects in methyl predenisolone-induced hypertensive rats. Additionally, pharmacokinetic parameters this compound are assessed. Methods:eupalitin-3-O-β-D-galactopyranoside was leaves by sedimentation method. The characterized UPLC-MSMS, NMR, UV spectroscopy confirm identity compound. Hypertension induced rats predenisolone (5 mg/kg/day) for 14 days. Systolic diastolic pressure 3-O-β-D-galactopyranoside were assessed using tail-cuff plasma data oral administration determine various bioavailability serum concentration. Results: In rats, both systolic pressures significantly lower than that vehicle (p < 0.01). Conclusions: process showed moderate compound; induces powerful activity implying clinical application as new therapeutic drug

Language: Английский

Citations

0