Clinical Public Databases in Hidradenitis Suppurativa: A Viewpoint (Preprint)

Interactive Journal of Medical Research, Journal Year: 2025, Volume and Issue: 14, P. e70282 - e70282

Published: Feb. 7, 2025

In this viewpoint, we argue that recent studies using clinical public databases have revolutionized our understanding of hidradenitis suppurativa (HS), a chronic inflammatory skin condition with significant impacts on patients’ quality life. Our key messages are as follows: (1) these enable large-scale integrating genetic, epidemiological, and data, providing crucial insights into HS’s genetic predispositions, comorbidities, treatment outcomes; (2) findings highlight strong component, mutations in the γ-secretase complex playing role HS pathogenesis shaping targeted therapies; (3) also reveal elevated risks for comorbidities like obesity, diabetes, cardiovascular disease, systemic inflammation patients HS, diet-driven pathways potentially exacerbating disease severity; (4) while offer unprecedented research opportunities, limitations such data representativeness must be considered; (5) nonetheless, their benefits outweigh potential drawbacks, allowing identification rare progression patterns, personalized strategies; (6) increased funding is to harness databases’ full potential, develop therapies, ultimately improve patient outcomes. As impact disproportionate current investments, believe advocating more resources addressing database will advancing care.

Language: Английский

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Evaluating the impact of high-dose vitamin D3, vitamin C, vitamin E, and zinc supplementation on inflammatory cytokines, lesion severity, and symptom management in hidradenitis suppurativa

International Journal of Research in Dermatology, Journal Year: 2025, Volume and Issue: 11(2), P. 199 - 207

Published: Feb. 24, 2025

This integrative, holistic review critically evaluates the impact of high-dose vitamin D3, C, E, and zinc supplementation on inflammatory cytokine levels, lesion severity, symptom management in patients with hidradenitis suppurativa (HS). By integrating data from recent clinical trials observational studies, we explore how these supplements influence key aspects HS pathology. High-dose D3 has been shown to significantly reduce levels cytokines decrease suggesting its role modulating immune responses improving disease outcomes. Similarly, antioxidant properties vitamins C E are assessed for their ability oxidative stress inflammation, which may lead improved reduced severity lesions. Zinc supplementation, particularly form sulfate, is examined effects enhancing skin barrier function decreasing frequency flares. Collectively, nutritional interventions offer a multifaceted approach management, highlighting potential combining optimize therapeutic The findings underscore need further research determine optimal dosing, duration, interaction standard treatments establish comprehensive protocols.

Language: Английский

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Hidradenitis Suppurativa Cancer Risk: A Review of the Literature

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 617 - 626

Published: March 1, 2025

This systematic review explores the increased cancer risk in patients with hidradenitis suppurativa (HS), particularly cutaneous squamous cell carcinoma (SCC) and lymphoma. Chronic inflammation immune dysregulation HS are identified as key factors contributing to malignant transformation, often observed areas of prolonged tissue damage. The NOTCH signaling pathway, disrupted by smoking, plays a dual role cancer, acting both tumor suppressor proto-oncogene depending on context. Mutations TP53 common SCC linked HS, prevalence 0.5% 4.6%, predominantly men localized buttock anogenital regions. Histological analyses suggest that transformation occurs within keratinized epithelium, supported altered cytokeratin expression. Immune HS-affected areas, compounded scarring lymphatic disruption, further exacerbates tumorigenic potential. While anti-TNF-alpha therapies have been implicated risk, conflicting evidence meta-analyses no consistent increase non-melanoma skin cancers (NMSC). Similarly, IL-17 inhibitors show potential risks but lack robust HS-specific populations. In conclusion, HS-associated malignancies, SCC, underscore need for research elucidate mechanisms linking chronic development. Insights from such studies could guide preventative therapeutic strategies, improving outcomes patients.

Language: Английский

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Evaluation of the Psychosocial Burden of Hidradenitis Suppurativa and Relevant Factors: A Prospective Single-Center Study

SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital, Journal Year: 2025, Volume and Issue: unknown, P. 28 - 34

Published: Jan. 1, 2025

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder in which patients with HS experience profound deterioration their overall well-being, psychological state and quality of life. This study aimed to evaluate the impact examined its associations relevant factors, including sociodemographic disease-related characteristics. A prospective, single-center was conducted involving 80 HS. The demographic clinical characteristics were recorded. Depression Anxiety Stress Scale-21 (DASS-21), Dermatology Life Quality Index (DLQI), General Health Questionnaire-12 (GHQ-12) used assess psychosocial significant proportion had severe extremely scores depression, anxiety stress, 48.75%, 52.5%, 48.75% patients, respectively. Sixty percent exhibited high disorders while 53.8% experienced impairment life (QoL). Sociodemographic factors evaluated for scales this study. DASS-21 (DASS-21A) significantly positively correlated lower education levels higher body mass index (BMI) (p<0.05). There no correlations between Hurley stages other three scales, except (DASS-21S) subscale. Patients family history DASS-21A, (DASS-21D), DASS-21S, GHQ-12 (both Likert traditional scoring) compared those without Additionally, positive predicted on DASS-21D, DASS-21S (p=0.002; p=0.019; p=0.022, respectively). Our findings confirm that or all assessing burden negatively affected psychologically at each stage. Family proved be strong predictive factor contributing impaired status among individuals Thus, dermatologists should provide extra care, especially members by condition.

Language: Английский

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Hidradenite supurativa: uma revisão da literatura

Journal Archives of Health, Journal Year: 2024, Volume and Issue: 5(3), P. e2024 - e2024

Published: July 30, 2024

A hidradenite supurativa (HS) é uma condição médica marcada por inflamação crônica causada pela obstrução dos folículos pilosos. Geralmente, esta doença afeta regiões da pele sujeitas a atrito, como axilas, virilha e nádegas. Os sintomas comuns incluem nódulos dolorosos sob pele, abscessos, cicatrizes secreção de pus. O tratamento envolve combinação antibióticos, anti-inflamatórios mudanças no estilo vida, boa higiene. presente artigo revisa causa doença, destaca os opções tratamento, com foco nos estágios gravidade acordo classificação Hurley, visando fornecer aos profissionais saúde o conhecimento necessário para gerenciar pacientes essa condição.

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Targeted Therapy Outcomes in Hidradenitis Suppurativa: A Systematic Review

American Journal of Therapeutics, Journal Year: 2024, Volume and Issue: 32(1), P. e114 - e116

Published: Oct. 25, 2024

Language: Английский

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Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study

Biomedical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 100816 - 100816

Published: Nov. 1, 2024

Language: Английский

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hUC-MSC extracellular vesicles protect against hypoxic-ischemic brain injury by promoting NLRP3 ubiquitination

Biomolecules and Biomedicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Hypoxic-ischemic brain injury (HIBD) is a major cause of neonatal mortality and long-term neurological deficits, with limited treatment options. Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) have shown promise in neuroprotection, but the mechanisms remain unclear. This study explores how hUC-MSC-EVs protect rats HIBD. were isolated, characterized, administered to subjected Behavioral reflexes infarction assessed, along cellular molecular analyses hippocampal tissue. An vitro oxygen–glucose deprivation/reoxygenation (OGD/R) model was used simulate ischemic conditions rat primary microglia. Results demonstrated that significantly improved outcomes, reduced infarction, decreased microglial activation pyroptosis. These effects linked inhibition NLRP3 inflammasome enhanced ubiquitination via protein kinase A (PKA) pathway. Blocking PKA partially reversed these protective effects. Here we highlight provide neuroprotection by regulating inflammasome, offering potential therapeutic strategy for findings expand understanding EV-mediated suggest broader applications ischemia-related conditions, clinical translation.

Language: Английский

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