Arrhythmogenic Potential of Myocardial Edema: The Interstitial Osmolality Induces Spiral Waves and Multiple Excitation Wavelets DOI Creative Commons
Diana G. Kiseleva,

V.D. Dzhabrailov,

Aleria A. Aitova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1770 - 1770

Published: Aug. 6, 2024

Myocardial edema is a common symptom of pathological processes in the heart, causing aggravation cardiovascular diseases and leading to irreversible myocardial remodeling. Patient-based studies show that associated with arrhythmias. Currently, there are no have examined how may influence changes calcium dynamics functional syncytium. We performed optical mapping on monolayer neonatal rat cardiomyocytes Fluo-4. The osmolality solutions was adjusted using NaCl content. initial Tyrode solution contained 140 mM (1T) hypoosmotic 105 (0.75T) 70 (0.5T). This study demonstrated sharp decrease wave propagation speed osmolality. successive also showed transition from normal wavefront spiral multiple wavelets excitation break. Our that, cellular model, hypoosmolality and, as consequence, edema, could potentially lead fatal ventricular arrhythmias, which our knowledge has not been studied before. At 0.75T waves appeared, whereas occurred 0.5T, had recorded previously two-dimensional under conditions cell without pacing protocol.

Language: Английский

Arrhythmogenic Potential of Myocardial Edema: The Interstitial Osmolality Induces Spiral Waves and Multiple Excitation Wavelets DOI Creative Commons
Diana G. Kiseleva,

V.D. Dzhabrailov,

Aleria A. Aitova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1770 - 1770

Published: Aug. 6, 2024

Myocardial edema is a common symptom of pathological processes in the heart, causing aggravation cardiovascular diseases and leading to irreversible myocardial remodeling. Patient-based studies show that associated with arrhythmias. Currently, there are no have examined how may influence changes calcium dynamics functional syncytium. We performed optical mapping on monolayer neonatal rat cardiomyocytes Fluo-4. The osmolality solutions was adjusted using NaCl content. initial Tyrode solution contained 140 mM (1T) hypoosmotic 105 (0.75T) 70 (0.5T). This study demonstrated sharp decrease wave propagation speed osmolality. successive also showed transition from normal wavefront spiral multiple wavelets excitation break. Our that, cellular model, hypoosmolality and, as consequence, edema, could potentially lead fatal ventricular arrhythmias, which our knowledge has not been studied before. At 0.75T waves appeared, whereas occurred 0.5T, had recorded previously two-dimensional under conditions cell without pacing protocol.

Language: Английский

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