Fine particulate matter components and reproductive hormones in female adults: A 15-year longitudinal cohort study

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114562 - 114562

Published: March 18, 2025

Few cohort studies have evaluated the long-term impacts of ambient fine particulate matter (PM2.5) and its components on reproductive hormone levels in female adults. We conducted a 15-year retrospective study Taiwan between 2003 2017. The two-year average concentrations PM2.5 components, including sulfate (SO42-), nitrate (NO3-), ammonium (NH4+), organic (OM), black carbon (BC), were assessed at each participant's addresses. Linear mixed models used to examine associations with hormones, follicle-stimulating (FSH), luteinizing (LH), testosterone (T), estradiol (E2), prolactin (PRL). Stratified analyses identify vulnerable populations. 17,152 adults included. Each interquartile range (IQR: 3.545 μg/m3) increase was associated 0.585 mIU/mL [95% confidence interval (CI): 0.190-0.980] FSH levels. Among five PM2.5, BC had strongest positive association [each IQR (0.272 0.863 (95% CI: 0.476-1.250) levels], followed by OM, SO42-, NH4+. Similar found for LH, 0.483 0.225-0.742) 0.684 0.431-0.938) LH per BC, respectively. pollutants marginally decreased E2 increased PRL Non-linear FSH, E2, observed. These also positively T among young Post-menopausal women more susceptible chronic components. Our highlighted adverse exposure hormonal homeostasis, revealing biological mechanism air pollution-reproductive health females. Implementing stringent control pollution can benefit adults, even moderately polluted regions.

Language: Английский

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Microencapsulated Phytochemicals from Coriandrum sativum Enhance Ovarian Function and Modulate Gene Expression in Testosterone-Induced PCOS

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105862 - 105862

Published: Jan. 1, 2025

Language: Английский

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Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Reproductive health is a critical determinant of livestock productivity and economic sustainability. However, it often compromised by infectious diseases, environmental stressors, nutritional deficits. Phytogenic extracts—bioactive compounds derived from medicinal plants—have emerged as sustainable alternatives to synthetic antibiotics hormones, exhibiting antimicrobial, antioxidant, immunomodulatory properties. These extracts influence key reproductive processes such follicular development, oocyte maturation, endometrial while mitigating the detrimental effects oxidative stress pathogenic infections. Recent findings suggest that phytogenic extract can enhance performance, improve quality, support pregnancy outcomes. Despite growing body evidence, optimal application strategies full breadth their biological remain insufficiently explored. This review focuses on molecular mechanisms modulated extracts, particularly in context hormone regulation, immune modulation, mitigation. We also identify knowledge gaps propose future research directions optimize use approach enhancing health.

Language: Английский

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The Role of Aromatic Amino Acids in Polycystic Ovary Syndrome through Patients’ Blood Metabolic Profiling: A Systematic Review of the Past Five Years

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age that encompasses multitude signs symptoms, including hyperandrogenism, polycystic ovarian morphology, ovulatory dysfunction, insulin resistance. The study aims to explore the role aromatic amino acid (AAA) disorders syndrome. A systematic search on databases Scopus, PubMed, Google Scholar until 20 July 2024 over past 5 years regarding metabolomic studies PCOS patients' blood status AAAs resulted 12 related papers. Our review showed AAA pathways are dysregulated, their levels serum plasma patients most elevated due inflammation oxidative stress which, assisted by gut dysbiosis, give rise resistance develops into PCOS. abnormalities can also directly induce defining symptoms through diminished neurotransmitter availability impaired signaling. According our review, perturbations detected every stage pathophysiology, making them valuable biomarkers for early diagnosis management Further investigation biological function, role, impact AAAs, probably alongside other metabolites, BCAAs, could lead discovery new tools preventing managing symptoms.

Language: Английский

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Efficacy of physical activity in polycystic ovary syndrome treatment

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2024, Volume and Issue: 31(6), P. 216 - 221

Published: Sept. 20, 2024

Purpose of review Physical activity (PA) is acknowledged as an important component lifestyle therapy in the management polycystic ovary syndrome (PCOS). The purpose this current systematic to analyze recent literature assessing role PA and exercise interventions potential treatment for PCOS. Recent findings published since 2022 has focused on understanding specific benefits different modalities PCOS pathophysiology, suggesting that high intensity may relay greater metabolic improvements, although results are still inconclusive; expanding our impact a wider range outcomes, including sleep, quality life, inflammation, DNA methylation; recognizing barriers limitations implementing efficacious individuals with Summary Current supports improving PCOS-related cardiometabolic reproductive outcomes; however, there significant evidence gap high-quality studies optimal regimens well strategies real-world settings

Language: Английский

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Effect of Oral Administration of Dehydroepiandrosterone on PCOS-Like Phenotype of Female C57BL/6 Mice

Jurnal Sain Peternakan Indonesia, Journal Year: 2024, Volume and Issue: 19(2), P. 111 - 116

Published: July 24, 2024

We aim to evaluate the efficacy and optimal dose of orally administered DHEA in PCOS mice model by assessing their ovarian morphology serum FSH, LH, testosterone levels. Female C57BL/6 were divided into a control group (n=5, received daily injections 0.2 ml sesame oil) an experimental group, which was further classified 1) D-45 (n=5), 2) D-60 3) D-90 (n=5) that treated with 45, 60, 90 mg/Kg body weight oral DHEA. After modelling, had regular estrous cycle, while all groups disturbed cycle. Ovarian histology showed several growing follicles some corpora lutea (CL) control, D-60, groups. However, large antral decreased CL observed group. Serum FSH significantly lower than (3.73 ± 0.12 vs. 5.28 0.31 mIU/mL, P<0.01), but similar level (P>0.05). The LH elevated (2.52 0.43 1.30 0.33 P<0.01 1.80 0.32 1.24 0.23 ng/mL, P<0.01, respectively). Still, comparable Our study suggests administration is efficacious establishing PCOS-like phenotype suggested dosage 45 weight.

Language: Английский

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Causal Relationship Between Inflammatory Cytokines and Polycystic Ovary Syndrome: A Bidirectional Mendelian Randomization Study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Polycystic ovary syndrome (PCOS) is defined as a chronic low-grade inflammatory reproductive endocrine disorder. PCOS can induce various metabolic disorders, which are associated with state of mild and slow-acting inflammation. Nevertheless,it‘s uncertain that the causation about factors. The causality between cytokines was analyzed by bidirectional Mendelian randomization (MR) in this current probe. We performed an interactive MR study to assess causal relationships 91 using Genome Wide Association Study (GWAS) data. underwent dual-sample analysis inverse variance weights (IVW) predominant methodology multiple validity heterogeneity analyses. MR-Egger, weighted median, simple mode, mode MR-PRESSO were likelihood sensitivity analyses enhance final results.The results came out interleukin-1-alpha (IL-1A) levels (odds ratio [OR] = 1.051, 95% fiducial interval [95% CI] 1.009–1.095, P 0.02) oncostatin-M (OSM) ( 1.041, 1.001–1.082, 0.04) positively development PCOS. Moreover, interleukin-7 (IL-7) ([OR] 0.935, 0.884–0.989, 0.02); interleukin-15 receptor subunit alpha (IL15RA) 0.959, 0.929–0.99, 0.01); C-X-C motif chemokine 11 (CXCL11) 0.922–0.996. 0.03) strongly negatively However, we did not find any strong positive reverse analysis, suggesting although factors contribute pathogenesis PCOS, itself does trigger factor production.Our provides genetic evidence for connection systemic regulators Treatments targeting specific may help mitigate risk five included study, namely, IL1A OSM, OSM progression while IL-7, IL15RA, CXCL11 correlated

Language: Английский

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Assessing body composition through anthropometry: Implications for diagnosing and managing polycystic ovary syndrome (PCOS)

Clinical Physiology and Functional Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder with profound implications for the reproductive and metabolic health of women. The utilization anthropometric measures in diagnosis management PCOS has gained increasing attention due to their practicality predictive capacity associated conditions such as obesity insulin resistance. This review rigorously explores application various indices, including body mass index, waist‐to‐hip ratio, advanced metrics shape index roundness wrist circumference, neck circumference. These indices offer critical insights into fat distribution its association hormonal perturbations characteristic PCOS. underscores necessity addressing obesity, prevalent comorbidity PCOS, through lifestyle modifications personalized therapeutic approaches. By incorporating evaluations routine clinical practice, healthcare professionals can enhance diagnostic precision, optimize treatment strategies, ultimately improve patient outcomes. integrative approach not only facilitates challenges inherent but also contributes development more individualized interventions, thereby enhancing overall quality life women affected by

Language: Английский

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Impact of Dietary Patterns and Serum Amino Acid Profile on Metabolic Syndrome Development in Mexican Women with Polycystic Ovary Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11821 - 11821

Published: Nov. 4, 2024

Polycystic ovary syndrome (PCOS) is the main endocrine disorder in women of reproductive age worldwide. This condition often associated with various metabolic alterations that contribute to development (MetS). Recent research suggests branched-chain amino acid (BCAA) dysregulation observed PCOS. study aims investigate relationship between dietary patterns, body composition, analytes, and serum levels Mexican Utilizing a cross-sectional design, we found both groups, PCOS (n = 24) + MetS 21), exhibited increased relative fat mass habits characterized by high simple sugar intake low protein consumption, correlating leptin. Notably, concentrations BCAAs glutamic were significantly elevated group. Our findings suggest approach may enhance prediction management PCOS, highlighting importance interventions this population.

Language: Английский

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Atractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113817 - 113817

Published: Dec. 25, 2024

Language: Английский

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