Insights into Medication-Induced Osteonecrosis of the Jaw Through the Application of Salivary Proteomics and Bioinformatics DOI Open Access
Vladimíra Schwartzová, Galina Laputková, Ivan Talian

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12405 - 12405

Published: Nov. 19, 2024

Long-term treatment with bisphosphonates is accompanied by an increased risk of medication-related osteonecrosis the jaw (MRONJ). Currently, no clinically useful biomarkers for predictive diagnosis MRONJ are available. To investigate potential key proteins involved in pathogenesis MRONJ, a proteomic LC-MS/MS analysis saliva was performed. Differentially expressed (DEPs) were analyzed using BiNGO, ClueGO, cytoHubba, MCODE, KEGG, and ReactomeFI software packages Cytoscape platforms. In total, 1545 DEPs identified, including 43 up- 11 down-regulated 1.5-fold cut-off value

Language: Английский

Crosstalk Between H-Type Vascular Endothelial Cells and Macrophages: A Potential Regulator of Bone Homeostasis DOI Creative Commons

Jiaxuan Fan,

Yaohui Xie,

Dayin Liu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2743 - 2765

Published: Feb. 1, 2025

The crosstalk between H-type endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression platelet-endothelial cell adhesion molecule-1 (CD31) mucin (EMCN), thereby facilitating angiogenesis-osteogenesis coupling during formation. Macrophages, as key immune the perivascular region, are primarily classified into classically activated pro-inflammatory M1 phenotype selectively anti-inflammatory M2 phenotype, performing dual functions regulating local tissue homeostasis innate immunity. In recent years, complex vessel has garnered significant interest context bone-related diseases. Orderly regulation immunity provides a new direction preventing metabolic disorders such osteoporosis osteoarthritis. However, their interactions remain insufficiently understood, with limited clinical data available. This review comprehensively examines intricate diverse phenotypes, Insights signaling pathways that regulate crosstalk, focusing on roles osteogenesis. Furthermore, discusses interventions targeting this challenges remain. These insights may offer perspectives provide theoretical foundation developing novel therapeutic strategies.

Language: Английский

Citations

0
Differential risk of autoimmune disorders in Non-Traumatic Osteonecrosis: clue to pathogenesis DOI
Edward Y. Cheng, Alireza Mirzaei

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Non-traumatic osteonecrosis is a frequent complication in patients with autoimmune disorders, though its prevalence varies markedly depending upon the type of disorder. Understanding causes this difference can help uncover underlying pathophysiology and guide development effective preventive therapeutic strategies. In perspective study, we reviewed available databases, including PubMed, Cochrane Library, Scopus, Web Science, to explore why risk among different disorders. Is variation primarily due disease's pathophysiology, use medications such as corticosteroids, or combination both? If both factors are involved, what extent each contribution context? often induced by an interaction between disease corticosteroid use. disorders but identical history use, influenced how compromises bone health. multiple adverse effects on bone, SLE (systemic lupus erythematosus), there much higher compared minimal impact health, celiac MS (multiple sclerosis).

Language: Английский

Citations

0
Microstructural and transcriptomic characterization of trabecular bone in idiopathic osteonecrosis of the femoral head DOI Creative Commons
Laura Saldaña,

Gema Vallés,

Nuria Vilaboa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

Language: Английский

Citations

0
Exploring the feasibility of pharmacologic management in non-traumatic osteonecrosis: An etiology-based hypothesis DOI
Edward Y. Cheng, Alireza Mirzaei

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 193, P. 111497 - 111497

Published: Oct. 9, 2024

Language: Английский

Citations

1
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis DOI
Edward Y. Cheng, Alireza Mirzaei

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: 28(11), P. 991 - 1000

Published: Oct. 29, 2024

Non-traumatic osteonecrosis is a debilitating condition marked by bone death, primarily due to reduced blood supply. Currently, no effective pharmacologic intervention available manage this effectively.

Language: Английский

Citations

1
Identification of shared gene signatures for diagnosing Systemic lupus erythematosus with osteonecrosis of the femoral head through bioinformatics analysis and machine learning DOI Creative Commons

Fei-Long Lu,

Wenbin Zhang, Yulin Ma

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Abstract Background: Osteonecrosis of the femoral head (ONFH) is a severe complication systemic lupus erythematosus (SLE). Although there characteristic disease spectrum between SLE and ONFH, exact pathogenesis remains unclear. Furthermore, lack early diagnostic criteria complicates diagnosis SLE-ONFH. This study aimed to identify key candidate genes in patients with ONFH. Methods: ONFH datasets were obtained from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) module identified using Limma Weighted Co-expression Network Analysis (WGCNA), followed by Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses. A protein‒protein interaction (PPI) network was constructed, machine learning algorithms—extreme gradient boosting (XGB), support vector (SVM), random forest (RF), generalized linear models (GLMs)—were applied hub for diagnosing combined Receiver operating (ROC) curves nomograms generated. Results: The dataset included 493 DEGs 1,171 genes. 384 525 By intersecting genes, total 74 obtained, which mainly enriched "chemokine signaling pathway" "cytokine‒cytokine receptor pathway." constructing PPI network, 22 node identified. Using learning, five highest scores selected nomogram construction value evaluation. all demonstrated high value. Conclusion: results this indicate that ELANE, LTF, ALAS2, MX1, CA1 are provides new direction clinical prediction

Language: Английский

Citations

0
Insights into Medication-Induced Osteonecrosis of the Jaw Through the Application of Salivary Proteomics and Bioinformatics DOI Open Access
Vladimíra Schwartzová, Galina Laputková, Ivan Talian

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12405 - 12405

Published: Nov. 19, 2024

Long-term treatment with bisphosphonates is accompanied by an increased risk of medication-related osteonecrosis the jaw (MRONJ). Currently, no clinically useful biomarkers for predictive diagnosis MRONJ are available. To investigate potential key proteins involved in pathogenesis MRONJ, a proteomic LC-MS/MS analysis saliva was performed. Differentially expressed (DEPs) were analyzed using BiNGO, ClueGO, cytoHubba, MCODE, KEGG, and ReactomeFI software packages Cytoscape platforms. In total, 1545 DEPs identified, including 43 up- 11 down-regulated 1.5-fold cut-off value

Language: Английский

Citations

0