Increased Risk of Early-Onset Endometrial Cancer in Women Aged 20–39 Years with Non-Alcoholic Fatty Liver Disease: A Nationwide Cohort Study

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1322 - 1322

Published: April 14, 2025

Background/Objectives: Given the rising incidence of early-onset endometrial cancer diagnosed before age 50 years, this study examined whether non-alcoholic fatty liver disease (NAFLD) served as an independent risk factor for cancer, irrespective obesity status. Methods: This nationwide cohort included 2,311,949 Korean women aged 20–39 years who underwent health screenings from 2009 to 2012. NAFLD severity was classified based on index: none (<30), moderate (30–59), and severe (≥60). Multivariable-adjusted Cox proportional hazards models were applied estimate adjusted hazard ratios (aHRs) cancer. Results: During a median follow-up 7.6 1289 developed The cumulative significantly higher in with than those without (log-rank p < 0.001). A dose-dependent association observed, increased corresponding greater (aHR [95% confidence interval (CI)]: NAFLD, 2.38 [1.99–2.85]; 5.39 [4.44–6.53]; trend 0.01). Compared non-obese aHRs 2.53 [2.11–3.05] 1.66 [1.10–2.52] obese 4.30 [3.60–5.13] (synergy index = 1.50, Conclusions: independently associated both women. Furthermore, young exhibited synergistically elevated risk. Early identification management may help mitigate rapidly growing burden

Language: Английский

Endometrial thickness and its diagnostic utility in postmenopausal women: A retrospective analysis of ultrasound and histopathological findings

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101509 - 101509

Published: April 21, 2025

Language: Английский

A 10-Year Retrospective Cohort Study of Endometrial Cancer Outcomes and Associations with Lymphovascular Invasion: A Single-Center Study from Germany

Diagnostics, Journal Year: 2024, Volume and Issue: 14(15), P. 1686 - 1686

Published: Aug. 4, 2024

This 10-year retrospective cohort study at a single-center clinic in Germany aimed to analyze the outcomes of endometrial cancer patients and explore impact lymphovascular invasion (LV) on patient disease-free survival (DFS). Identifying correlations among demographic data, tumor characteristics, treatment modalities, could enhance management improve rates. The encompassed diagnosed treated for from January 2010 December 2020. Clinical pathological data were extracted medical records 311 patients, focusing variables such as age, histological type, grade, type surgical treatment, adjuvant therapies. Survival analysis was conducted using Kaplan-Meier method multivariate Cox proportional hazard models identify factors independently associated with survival. demonstrated that significantly impacted (log-rank

Language: Английский