Gender-Related Difference in Skin Oxygenation in Young Patients with Uncomplicated Type 1 Diabetes
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1413 - 1413
Published: June 25, 2024
Gender,
through
genetic,
epigenetic
and
hormonal
regulation,
is
an
important
modifier
of
the
physiological
mechanisms
clinical
course
diseases.
In
diabetes
mellitus,
there
are
gender
differences
in
incidence,
prevalence,
morbidity,
mortality.
This
disease
also
has
impact
on
microvascular
function.
Therefore,
this
cross-sectional
study
was
designed
to
investigate
how
affects
cutaneous
microcirculation.
We
hypothesized
that
should
be
factor
interpretation
capillaroscopy
transcutaneous
oxygen
saturation
results.
The
group
consisted
42
boys
55
girls,
uncomplicated
diabetic
pediatric
patients.
Females
(F)
males
(M)
did
not
differ
terms
age,
age
at
onset
diabetes,
or
duration.
Furthermore,
they
metabolic
parameters.
comparison
showed
F
had
lower
BP,
higher
pulse,
HR
than
M.
Group
significantly
creatinine
hemoglobin
levels
children
adolescents
with
type
1
without
complications,
a
difference
microcirculatory
resting
partial
pressure
females
males.
However,
were
no
gender-related
basal
capillaroscopic
parameters
vascular
reactivity
during
PORH
test.
Our
results
indicate
studies
investigating
structure
function
microcirculation
consider
role
addition
known
cofactors
such
as
puberty,
body
mass
index,
physical
activity,
cigarette
smoking.
Language: Английский
Soluble P-Selectin as an Indicator of Cutaneous Microangiopathy in Uncomplicated Young Patients with Type 1 Diabetes
Life,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1587 - 1587
Published: Dec. 2, 2024
This
study
aimed
to
analyze
the
relationship
between
cutaneous
microcirculation
reactivity,
retinal
circulation,
macrocirculation
function,
and
specific
adhesion
molecules
in
young
patients
with
uncomplicated
type
1
diabetes.
Fifty-five
diabetes
mellitus
(T1DM),
aged
8
18
years,
were
divided
into
subgroups
based
on
skin
reactivity.
The
microcirculatory
vessels
considered
reactive
if
post-test
PORH
coverage
increased
compared
pre-test
coverage.
Optical
coherence
tomography
(OCT)
was
conducted
detect
early
retinopathic
changes.
Macrocirculation
described
using
pulsatility
indices
(PIs)
determined
for
common
carotid
(CCA)
peripheral
arteries
of
upper
lower
limbs.
ankle–brachial
index
also
assessed.
There
no
significant
differences
circulation
studied
subgroups.
However,
there
various
concerning
age
at
onset
sP-selectin
levels
but
not
ICAM-1
sVCAM-1.
remained
true
after
adjusting
onset.
level
significantly
higher
subgroup
non-reactive
microcirculation.
results
our
indicate
that
may
be
as
an
immunological
marker
abnormalities,
which
serve
indicator
endothelial
dysfunction
absence
classical
complication.
Language: Английский