Vitamin D Deficiency as a Risk Factor for Diabetic Retinopathy: A Systematic Review and Meta-Analysis DOI Creative Commons

Claudia Elena Petrea,

Laura Andreea Ghenciu, Roxana Iacob

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 68 - 68

Published: Dec. 30, 2024

Diabetic retinopathy (DR), a significant microvascular complication of diabetes mellitus (DM), remains major cause vision loss worldwide. Vitamin D, recognized for its role in bone health, has also been implicated various non-skeletal conditions, including DR. This systematic review analyzed data from 20 studies involving 22,408 participants to explore the relationship between vitamin D levels and Studies were included based on strict eligibility criteria, ensuring they could distinctly classify into DR non-DR groups provide quantitative measurements levels. Of these, nine meta-analysis. The pooled analysis revealed association lower increased odds DR, with combined ratio (OR) 1.15 (95% CI: 1.10–1.20) under fixed-effects model 1.17 1.08–1.27) random-effects model. Mean serum individuals (18.11 ± 5.35 ng/mL) compared those without (19.71 7.44 ng/mL), progressive decline observed across severity stages. Subgroup analyses showed significantly proliferative non-proliferative Heterogeneity (I2 = 89%) was noted, most probably due geographic differences, varying methodologies measurement, classification approaches. Secondary indicated that deficiency prevalence ranged 27% 95% populations, highlighting potential disease progression. highlights need longitudinal better understand causal relationship. findings call attention critical gap literature regarding therapeutic supplementation preventing managing Addressing as modifiable risk factor DM care may offer new avenues reducing burden

Language: Английский

Emerging Therapeutic Approaches and Genetic Insights in Stargardt Disease: A Comprehensive Review DOI Open Access
Laura Andreea Ghenciu,

Ovidiu Alin Hațegan,

Emil Robert Stoicescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8859 - 8859

Published: Aug. 14, 2024

Stargardt disease, one of the most common forms inherited retinal diseases, affects individuals worldwide. The primary cause is mutations in ABCA4 gene, leading to accumulation toxic byproducts pigment epithelium (RPE) and subsequent photoreceptor cell degeneration. Over past few years, research on disease has advanced significantly, focusing clinical molecular genetics. Recent studies have explored various innovative therapeutic approaches, including gene therapy, stem pharmacological interventions. Gene therapy shown promise, particularly with adeno-associated viral (AAV) vectors capable delivering cells. However, challenges remain due gene’s large size. Stem aims replace degenerated RPE cells, several trials demonstrating safety preliminary efficacy. Pharmacological approaches focus reducing byproduct modulating visual cycle. Precision medicine, targeting specific genetic pathways, becoming increasingly important. Novel techniques such as clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 offer potential for directly correcting defects. This review synthesize recent advancements understanding treating disease. By highlighting breakthroughs therapies, treatments, novel strategies, it provides a comprehensive overview emerging options.

Language: Английский

Citations

9
Thyroid Eye Disease and Glaucoma: A Cross-Sectional Study Comparing Clinical Characteristics and Disease Severity DOI Creative Commons
Laura Andreea Ghenciu,

Alina Maria Șișu,

Emil Robert Stoicescu

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1430 - 1430

Published: Sept. 1, 2024

Background and Objectives: This study investigates the relationship between thyroid eye disease (TED) open-angle glaucoma (OAG), focusing on severity clinical features. Materials Methods: Conducted at Timis County Emergency Clinical Hospital, research included 106 patients, with 53 having both conditions only OAG. Key metrics analyzed intraocular pressure (IOP) using a Goldmann applanation tonometer, retinal nerve fiber layer (RNFL) thickness, optic head (ONH) characteristics evaluated optical coherence tomography (OCT). Results: Results indicated that patients TED OAG experienced 6.09% reduction in RNFL thickness showed more rapid progression, 48.35% active TED. The mean IOP was 27.5 ± 4.9 mmHg, which similar to those Demographic factors, including age gender, influenced course severity. Conclusions: These findings underscore importance of specialized monitoring treatment strategies for coexisting prevent vision loss.

Language: Английский

Citations

8
Human Ocular Toxoplasmosis in Romania: History, Epidemiology, and Public Health: A Narrative Review DOI Creative Commons
Laura Andreea Ghenciu,

Ovidiu Alin Hațegan,

Sorin Lucian Bolintineanu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1541 - 1541

Published: July 27, 2024

Toxoplasmosis, caused by the protozoan parasite

Language: Английский

Citations

5
Cardiovascular Risk Factors in Socioeconomically Disadvantaged Populations in a Suburb of the Largest City in Western Romania DOI Creative Commons
Andreea Dumitrescu,

Gabriela Mut Vitcu,

Svetlana Stoica

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1989 - 1989

Published: Sept. 2, 2024

: Cardiovascular disease (CVD) remains a major public health issue worldwide, disproportionately affecting socioeconomically disadvantaged populations due to the social determinants of (SDOHs). In Western Romania, these are particularly vulnerable CVD. This study aims investigate prevalence and impact cardiovascular risk factors (CVRFs) among individuals in Romania identify primary CVRFs contributing high incidence CVD within this population.

Language: Английский

Citations

1
Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review DOI Creative Commons
Alexandra Corina Faur,

Alina Maria Șișu,

Laura Andreea Ghenciu

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(17), P. 1942 - 1942

Published: Sept. 3, 2024

Salivary gland tumors are a rare and heterogeneous group of neoplasms the head neck region. The mixed category these include following entities: pleomorphic adenoma (PA), carcinoma ex (CEPA), salivary carcinosarcoma (CS), metastasizing PA (MPA). most common benign tumor glands is PA. Metastasis malignant degeneration have been reported in cases origin. Judging by their behavior, MPA, CEPA, CS can be considered aggressive tumors. Invasive CEPA has identified parotid more frequently. MPA current literature rare. In this paper, we present, narratively, clinico-morphological features

Language: Английский

Citations

0
Vitamin D Deficiency as a Risk Factor for Diabetic Retinopathy: A Systematic Review and Meta-Analysis DOI Creative Commons

Claudia Elena Petrea,

Laura Andreea Ghenciu, Roxana Iacob

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 68 - 68

Published: Dec. 30, 2024

Diabetic retinopathy (DR), a significant microvascular complication of diabetes mellitus (DM), remains major cause vision loss worldwide. Vitamin D, recognized for its role in bone health, has also been implicated various non-skeletal conditions, including DR. This systematic review analyzed data from 20 studies involving 22,408 participants to explore the relationship between vitamin D levels and Studies were included based on strict eligibility criteria, ensuring they could distinctly classify into DR non-DR groups provide quantitative measurements levels. Of these, nine meta-analysis. The pooled analysis revealed association lower increased odds DR, with combined ratio (OR) 1.15 (95% CI: 1.10–1.20) under fixed-effects model 1.17 1.08–1.27) random-effects model. Mean serum individuals (18.11 ± 5.35 ng/mL) compared those without (19.71 7.44 ng/mL), progressive decline observed across severity stages. Subgroup analyses showed significantly proliferative non-proliferative Heterogeneity (I2 = 89%) was noted, most probably due geographic differences, varying methodologies measurement, classification approaches. Secondary indicated that deficiency prevalence ranged 27% 95% populations, highlighting potential disease progression. highlights need longitudinal better understand causal relationship. findings call attention critical gap literature regarding therapeutic supplementation preventing managing Addressing as modifiable risk factor DM care may offer new avenues reducing burden

Language: Английский

Citations

0