Tissue‐resident memory T cells in diseases and therapeutic strategies DOI Creative Commons
Daoyuan Xie, Guanting Lu,

Gang Mai

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract Tissue‐resident memory T (T RM ) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating cells, located within peripheral tissues, they play vital roles in antiviral, antibacterial, antitumor immunity. Their unique retention activation mechanisms, including interactions with local expression adhesion molecules, enable their persistence immediate functionality diverse tissues. Recent advances have revealed important chronic inflammation, autoimmunity, cancer, illuminating both protective pathogenic potential. This review synthesizes current knowledge on cells’ molecular signatures, maintenance pathways, functional dynamics across different We also explore other such as B macrophages, dendritic highlighting complex network underpins efficacy surveillance response. Understanding nuanced regulation is essential for developing targeted therapeutic strategies, vaccines immunotherapies, enhance while mitigating adverse effects. Insights into biology hold promise innovative treatments infectious diseases, autoimmune conditions.

Language: Английский

Tissue‐resident memory T cells in diseases and therapeutic strategies DOI Creative Commons
Daoyuan Xie, Guanting Lu,

Gang Mai

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract Tissue‐resident memory T (T RM ) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating cells, located within peripheral tissues, they play vital roles in antiviral, antibacterial, antitumor immunity. Their unique retention activation mechanisms, including interactions with local expression adhesion molecules, enable their persistence immediate functionality diverse tissues. Recent advances have revealed important chronic inflammation, autoimmunity, cancer, illuminating both protective pathogenic potential. This review synthesizes current knowledge on cells’ molecular signatures, maintenance pathways, functional dynamics across different We also explore other such as B macrophages, dendritic highlighting complex network underpins efficacy surveillance response. Understanding nuanced regulation is essential for developing targeted therapeutic strategies, vaccines immunotherapies, enhance while mitigating adverse effects. Insights into biology hold promise innovative treatments infectious diseases, autoimmune conditions.

Language: Английский

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