Emerging Approaches in Glioblastoma Treatment: Modulating the Extracellular Matrix Through Nanotechnology
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 142 - 142
Published: Jan. 21, 2025
Glioblastoma’s
(GB)
complex
tumor
microenvironment
(TME)
promotes
its
progression
and
resistance
to
therapy.
A
critical
component
of
TME
is
the
extracellular
matrix
(ECM),
which
plays
a
pivotal
role
in
promoting
tumor’s
invasive
behavior
aggressiveness.
Nanotechnology
holds
significant
promise
for
GB
treatment,
with
potential
address
challenges
posed
by
both
blood-brain
barrier
ECM.
By
enabling
targeted
delivery
therapeutic
diagnostic
agents,
nanotechnology
offers
prospect
improving
treatment
efficacy
accuracy
at
site.
This
review
provides
comprehensive
exploration
GB,
including
epidemiology,
classification,
current
strategies,
alongside
intricacies
TME.
It
highlights
nanotechnology-based
focusing
on
nanoparticle
formulations
such
as
liposomes,
polymeric
nanoparticles,
gold
have
shown
Furthermore,
it
explores
how
different
emerging
strategies
modulate
ECM
overcome
high
density,
restricts
drug
distribution
within
tumors.
emphasizing
intersection
ECM,
this
underscores
an
innovative
approach
advancing
treatment.
addresses
limitations
therapies,
identifies
new
research
avenues,
emphasizes
improve
patient
outcomes.
Language: Английский
Brain tumors. A bibliometric analysis of forty years by science mapping
The European Research Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: April 16, 2025
Objective:
Science
mapping
is
a
systematic
approach
to
analyzing
the
intricate
network
of
relationships
in
scientific
literature.
methodology
investigates
networks
among
articles,
authors,
journals,
keywords,
and
research
topics.
This
study
aims
comprehend
literature
field
brain
tumors.
Methods:
Our
covers
period
1980-2022.
uses
Web
database
for
reviews
bibliometric
analyses.
The
obtained
data
were
filtered
classified.
10,777
articles
analyzed
five
sections.
Some
sections
are:
structural
analysis
countries,
keyword
analysis,
thematic
collaboration
analysis.
Results:
have
been
published
1761
journals.
average
citation
per
article
38.22.
highest
h
g-index
values
belong
Cancer
Research.
For
from
1980
2022
has
analyzed.
During
2021-2022,
'Deep
Learning'
'Brain
Tumors'
formed
motor
themes.
authors'
Kun
LE
author
with
most
collaborations.
Conclusions:
Upon
examining
maps
all
periods,
it
assessed
that
likely
topics
scopes
future
on
tumors
will
be
biomarkers,
personalized
treatments,
artificial
intelligence,
immunotherapy,
pediatric
Language: Английский