Diabetic peripheral neuropathy based on Schwann cell injury: mechanisms of cell death regulation and therapeutic perspectives
Lijiao Wu,
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Xiang Jin Wang,
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Xi Luo
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et al.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 12, 2024
Diabetic
peripheral
neuropathy
(DPN)
is
a
complication
of
diabetes
mellitus
that
lacks
specific
treatment,
its
high
prevalence
and
disabling
neuropathic
pain
greatly
affects
patients’
physical
mental
health.
Schwann
cells
(SCs)
are
the
major
glial
nervous
system,
which
play
an
important
role
in
various
inflammatory
metabolic
neuropathies
by
providing
nutritional
support,
wrapping
axons
promoting
repair
regeneration.
Increasingly,
glucose
(HG)
has
been
found
to
promote
progression
DPN
pathogenesis
targeting
SCs
death
regulation,
thus
revealing
molecular
process
programmed
cell
(PCD)
disrupted
link
gain
insight
into
DPN.
This
paper
first
review
recent
progress
HG
studies
on
apoptosis,
autophagy,
pyroptosis,
ferroptosis
necroptosis
pathways
SCs,
points
out
crosstalk
between
PCDs
related
therapeutic
perspectives,
with
aim
new
perspectives
for
deeper
understanding
mechanisms
exploration
effective
targets.
Language: Английский
Metabolomics in Pathogenic Pathways and Targeted Therapies for Diabetic Neuropathy: A Comprehensive Review
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 86 - 86
Published: Feb. 1, 2025
Introduction
and
objective:
This
literature
review
aims
to
provide
an
overview
of
the
progress
in
metabolomic
assessment
animal
cell
models
humans
with
diabetic
neuropathy
(DN).
Methods:
Metabolomics
has
emerged
as
important
approach
for
investigating,
identifying,
describing
biomarkers
related
DN.
None
yet
been
validated
use
clinical
practice.
Results:
DN
induced
significant
alterations
energy
metabolism
carbohydrates,
lipids,
amino
acids,
peptides,
proteins.
Several
treatments
DN,
evaluated
using
metabolomics,
were
proved
have
promising
results.
Conclusions:
The
ideal
metabolite
or
set
metabolites
that
could
be
used
should
identify
patients
diabetes
prone
develop
those
severe
forms
sensory
loss,
associated
risk
ulcerations
amputation.
Another
potential
a
might
indicator
treatment
response
trials
agents
disease-modifying
properties.
Language: Английский
Comprehending the Role of Metabolic and Hemodynamic Factors Alongside Different Signaling Pathways in the Pathogenesis of Diabetic Nephropathy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3330 - 3330
Published: April 3, 2025
Diabetic
nephropathy
(DN)
is
a
progressive
microvascular
disorder
of
diabetes
that
contributes
as
primary
reason
for
end-stage
renal
disease
worldwide.
The
pathological
hallmarks
DN
include
diffuse
mesangial
expansion,
thicker
basement
membrane
glomeruli,
and
arteriole
hyalinosis.
Hypertension
chronic
hyperglycemia
are
the
risk
factors
contributing
to
occurrence
DN.
complex
pathophysiology
involves
interplay
amongst
metabolic
hemodynamic
pathways,
growth
cytokines
production,
oxidative
stress,
ultimately
impaired
kidney
function.
Hyperglycemia-induced
vascular
dysfunction
main
mechanism
initiates
However,
several
other
pathogenic
mechanisms,
such
inflammatory
cell
infiltration,
fibrosis,
contribute
progression.
Different
vasoactive
hormone
processes,
including
endothelin
renin-angiotensin,
activated
part
DN,
which
also
increased
intraglomerular
systemic
pressure.
will
continue
be
better
understood
because
recent
developments
in
genomics
molecular
biology,
but
attempts
develop
comprehensive
theory
explains
all
existing
cellular
biochemical
pathways
have
been
thwarted
by
disease's
multifactorial
nature.
This
review
extensively
discusses
current
understanding
regarding
along
with
signaling
molecules
responsible
pathogenesis
work
encourage
greater
in-depth
investigation
present
status
mechanistic
processes
underlying
may
assist
determination
different
biomarkers
help
design
development
novel
drug
candidates
near
future.
Language: Английский
Transcutaneous Application of Gaseous CO 2 Improves Diabetic Distal Symmetrical Polyneuropathy in Patients with and Without Chronic Wounds
The International Journal of Lower Extremity Wounds,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
The
study
explores
the
effects
of
non-invasive
transcutaneous
CO
2
therapy
on
diabetic
symmetrical
peripheral
polyneuropathy
(DSPN).
Overall,
we
included
120
patients
with
diabetes:
40
DSPN
(group
A)
and
foot
ulceration
(DFU)
B),
both
receiving
20
sessions
therapy;
not
treatment
C).
Outcomes
were
assessed
using
Semmes-Weinstein
monofilament
test,
128
Hz
tuning
fork
vibration
sensation,
hallux
temperature,
wound
dimensions,
adverse
effects.
There
was
a
significant
improvement
in
protective
sensation
for
-treated
groups.
Group
A
exhibited
53%
improvement,
while
B
improved
by
34%
(p
=
.002).
In
Groups
A,
30%
23%,
respectively.
Hallux
temperature
increased
more
(5.10
°C)
compared
(3.89
°C).
Improvement
observed
treated
groups,
regardless
ankle-brachial
index
(ABI),
best
results
having
borderline
ABI
(67.5%
53.1%
B).
conclusion,
effectively
alleviated
symptoms
with/without
DFUs,
normal
or
insufficient
circulation,
it
well-tolerated
without
Language: Английский