Predicting microvascular invasion in solitary hepatocellular carcinoma: a multi-center study integrating clinical, MRI assessments, and radiomics indicators

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 19, 2025

Microvascular invasion (MVI) is a key prognostic factor in solitary hepatocellular carcinoma (HCC), significantly affecting treatment decisions and outcomes. Early prediction of MVI crucial for enhancing clinical decision-making. This study aimed to develop evaluate four predictive models MVI: one based on indicators, MRI assessments, using radiomics, combined model integrating all data across multiple medical centers. The included patients with HCC from three centers (Mengchao Hepatobiliary Hospital, Second Hospital Nanping, Datian County General Hospital). dataset was divided into an internal training set, validation two external sets. Predictive were built MRI, combination these. Model performance assessed through ROC curves, calibration decision curve analysis (DCA). Lasso regression identified significant features, SHAP interpreted the predictions. A total 319 analyzed: 199 center, 67 53 Datian. model, which integrated clinical, radiomics showed superior performance, AUC 0.95(95%CI:0.92-0.98) 0.92(95%CI:0.83-1.00) 0.96(95%CI:0.92-1.00) 0.94(95%CI:0.88-0.99) Calibration curves confirmed model's accuracy, NRI/IDI analyses highlighted its advantage over individual models. Key indicators pseudocapsule, peritumoral enhancement, wavelet-based features. multi-center demonstrates effectiveness combining predicting HCC, robust results different These have potential improve patient management planning.

Language: Английский

miRNAs in HCC, pathogenesis, and targets

Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Liver cancer is the third leading cause of cancer-related mortality worldwide. HCC, most common type primary liver cancer, driven by complex genetic, epigenetic, and environmental factors. MicroRNAs, a class naturally occurring small noncoding RNAs, play crucial roles in HCC simultaneously modulating expression multiple genes fine-tuning manner. Significant progress has been made understanding how miRNAs influence key oncogenic pathways, including cell proliferation, apoptosis, angiogenesis, epithelial-mesenchymal transition (EMT), as well their role immune microenvironment HCC. Due to unexpected stability blood fixed tumors, recent advancements also highlight potential noninvasive diagnostic tools. Restoring or inhibiting specific offered promising strategies for targeted treatment suppressing malignant hepatocyte growth enhancing antitumor immunity. In this comprehensive review, we consolidate previous research provide latest insights into regulate therapeutic potential. We delve dysregulation miRNA biogenesis proliferation apoptosis hepatocytes, angiogenesis metastasis drug resistance. discuss delivery approaches drugs overcome limitations current options. By thoroughly summarizing our goal advance development effective with minimal adverse effects establish precise tools early diagnosis

Language: Английский