Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 7 - 7

Published: Jan. 2, 2025

Urinary stones (urolithiasis) have been categorized as kidney (renal calculus), ureteric (ureteral calculus and ureterolith), bladder (bladder urethral (urethral calculus); however, the mechanisms underlying their promotion related injuries in glomerular tubular cells remain unclear. Although lifestyle-related diseases (LSRDs) such hyperglycemia, type 2 diabetic mellitus, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, cardiovascular disease are risk factors for urolithiasis, Recently, heat shock protein 90 (HSP90) on membrane of HK-2 human proximal epithelium has associated with adhesion urinary cytotoxicity. Further, HSP90 pancreatic breast can be modified by various advanced glycation end-products (AGEs), thus affecting function. Hypothesis 1: We hypothesized that HSP90s on/in types AGEs, they may affect functions it a key to reveal LSRDs urolithiasis. 2: considered possibility Japanese traditional medicines urolithiasis inhibit AGE generation. Of Choreito Urocalun (the extract Quercus salicina Blume/Quercus stenophylla Makino) used clinic, is Kampo medicine, while characteristic medicine. As contains quercetin, hesperidin, p-hydroxy cinnamic acid, which generation, we generation AGE-modified cells.

Language: Английский

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Methylglyoxal Formation—Metabolic Routes and Consequences

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 212 - 212

Published: Feb. 13, 2025

Methylglyoxal (MGO), a by-product of glycolysis, plays significant role in cellular metabolism, particularly under stress conditions. However, MGO is potent glycotoxin, and its accumulation has been linked to the development several pathological conditions due oxidative stress, including diabetes mellitus neurodegenerative diseases. This paper focuses on biochemical mechanisms by which contributes through formation advanced glycation end products (AGEs), interactions with antioxidant systems, involvement chronic diseases like diabetes, neurodegeneration, cardiovascular disorders. exerts effects multiple signaling pathways, NF-κB, MAPK, Nrf2, induce stress. Additionally, triggers apoptosis primarily via intrinsic extrinsic while endoplasmic reticulum (ER) mediated PERK-eIF2α IRE1-JNK signaling. Moreover, activation inflammatory RAGE crucial pathogenesis these study points out connection between carbonyl increased formation, it should be an incentive search for marker that could have prognostic significance or targeted therapeutic intervention various

Language: Английский

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Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.

Language: Английский

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Dietary AGEs and food allergy: insights into the mechanisms of AGEs-induced food allergy and mitigation strategies

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: March 24, 2025

Food allergy (FA) is a significant public health concern, with over one billion individuals globally affected, and its prevalence continues to rise. Advanced glycation end products (AGEs) are common hazards in various diet. Recent investigations have shown that AGEs could influence the pathogenesis of FA by interacting receptors. This paper provides comprehensive review recent advances on diet AGEs, summarized mechanisms regulating food mitigation strategies, analyzed limitations current research prospected future research. combine receptors for (RAGE) induce oxidative stress, inflammation allergic signaling pathways. can affect allergen epitopes conformation regulate intestinal flora non-receptor-dependent manner, as well barrier Th1/Th2 immune balance through receptor-dependent pathways allergy. Currently, approaches reduce AGEs-induced mainly depended improving processing methods (e.g., low temperature, short time, pH non-thermal methods), natural inhibitors RAGE inhibitors. elucidates influences which provide novel insights into reducing induced AGEs.

Language: Английский

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RIBOsensor for FRET-based, real-time ribose measurements in live cells

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This protein sensor allows real-time intracellular quantitation of d -Ribose, which is a building block many essential biomolecules, including all nucleic acids.

Language: Английский

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