Dynamic changes of inflammatory markers in the early stages of chronic kidney disease in patients with type 1 diabetes mellitus DOI Creative Commons
М. В. Осиков, Л. А. Эфрос,

L.Y. Zhuravleva

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Diabetes mellitus (DM) is one of the major factors contributing to development and aggravation chronic kidney disease (CKD). The accurate convenient markers for early detection, estimation progression, adequate control CKD therapy in individuals with DM are limited glomerular filtration rate (GFR) albuminuria. Given role inflammation pathogenesis CKD, study aimed assess indicators correlation those GFR patients type 1 (T1D) stage CKD. involved healthy (n = 14), T1D showing no signs 30), as well 60), 2 38), 3 31). was calculated using formula СКD-ЕРI (eGFR); serum levels IL1β TNFα, C-reactive protein (CRP), ceruloplasmin (CP) were determined by enzyme immunoassay; neutrophil-to-lymphocyte index leukocyte intoxication (LII) calculated. It has been found that concentrations IL1β, CRP, CP elevated; LII increased. acute phase response severity progresses reaches its maximum 3b when concentration increased 2.4-fold (р 0.042), TNFα 34% 0.005), CRP 33-fold < 0.000), 73% 0.008), 8.4-fold 5-fold 0.013). integral function indicator, eGFR, decreases increasing above indicators. Thus, CP, LII, can be considered affordable informative inflammation, which increase progression T1D.

Language: Английский

Prognostic effect of neutrophil percentage-to-albumin ratio (NPAR) on all-cause and cardiovascular mortality in diabetic kidney disease (DKD): NHANES 1999–2018 DOI Creative Commons
Juntao Tan, Jinglong Du, Jiaxiu Liu

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 28, 2025

This study aimed to evaluate the associations between neutrophil percentage-to-albumin ratio (NPAR) and both all-cause cardiovascular mortality in diabetic kidney disease (DKD) patients. The data for this were sourced from National Health Nutrition Examination Survey (NHANES) 1999–2018. Weighted logistic regression, Cox proportional hazards model, Fine-Gray competing risk model used assess association NPAR DKD A total of 2,699 participants enrolled study. regression analysis revealed that elevated levels associated with a higher all (HR: 2.17, 95%CI: 1.83–2.58). Meanwhile, significant difference was observed males 1.83, 1.42–2.38) but not females. Finally, adjusted identified as an independent predictor (SHR: 1.86 1.28–2.72) In nationally representative sample US, detected increased mortality. addition, gender differences relationship also observed.

Language: Английский

Citations

0
Dysregulation of neutrophil extracellular traps (NETs)-related genes in the pathogenesis of diabetic kidney disease - Results from bioinformatics analysis and translational studies DOI

Ruiyan Xie,

Ka Ho Jason Sher,

Sin Yu Cindy Tang

et al.

Clinical Immunology, Journal Year: 2024, Volume and Issue: 268, P. 110379 - 110379

Published: Oct. 11, 2024

Language: Английский

Citations

2
Hemoglobin, albumin, lymphocyte, and platelet (HALP) score: A risk prediction tool for incidence and mortality in diabetic kidney disease patients with type 2 diabetes DOI Creative Commons

Lingzhi Xing,

Fang Xie, Zhaoyang Zhong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Background The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been identified as a potential prognostic marker in various conditions. However, its relationship with the incidence mortality of diabetic kidney disease (DKD) type 2 diabetes patients remains unexplored. This study aims to explore between HALP both DKD diabetes, well whether reversing could reduce outcomes. Methods included 25,750 from National Health Nutrition Examination Survey (NHANES) (1999–2018) Southwest China (2013–2022). was calculated [hemoglobin (g/L) × albumin (g/L)×lymphocytes (/L)]/platelets (/L). diagnosed based on urine creatinine ratio (ACR) ≥ 30 mg/g and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m². explored using logistic regression model, Cox models were used evaluate association all-cause cause-specific mortality. Subgroup analyses effects dietary fiber intake NSAIDs use Results Higher significantly associated lower risk (NHANES, HR 0.502; China, 0.528) an antagonist manner. Additionally, higher related decreased (HR 0.765, p 0.001) cardiovascular disease(CVD)-related mortality(HR 0.667, 0.001).We also discovered same outcome low 0.695, or 0.733, 0.001). magnitude associations not materially altered any sensitivity analyses. Conclusions High independently Regular monitoring aid stratification clinical decisions for diabetes.

Language: Английский

Citations

0
Dynamic changes of inflammatory markers in the early stages of chronic kidney disease in patients with type 1 diabetes mellitus DOI Creative Commons
М. В. Осиков, Л. А. Эфрос,

L.Y. Zhuravleva

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Diabetes mellitus (DM) is one of the major factors contributing to development and aggravation chronic kidney disease (CKD). The accurate convenient markers for early detection, estimation progression, adequate control CKD therapy in individuals with DM are limited glomerular filtration rate (GFR) albuminuria. Given role inflammation pathogenesis CKD, study aimed assess indicators correlation those GFR patients type 1 (T1D) stage CKD. involved healthy (n = 14), T1D showing no signs 30), as well 60), 2 38), 3 31). was calculated using formula СКD-ЕРI (eGFR); serum levels IL1β TNFα, C-reactive protein (CRP), ceruloplasmin (CP) were determined by enzyme immunoassay; neutrophil-to-lymphocyte index leukocyte intoxication (LII) calculated. It has been found that concentrations IL1β, CRP, CP elevated; LII increased. acute phase response severity progresses reaches its maximum 3b when concentration increased 2.4-fold (р 0.042), TNFα 34% 0.005), CRP 33-fold < 0.000), 73% 0.008), 8.4-fold 5-fold 0.013). integral function indicator, eGFR, decreases increasing above indicators. Thus, CP, LII, can be considered affordable informative inflammation, which increase progression T1D.

Language: Английский

Citations

0