The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma DOI
Liying Han, Xun Tian, Xinxin Yang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156666 - 156666

Published: March 1, 2025

Language: Английский

Advances in Pharmacological Research on Icaritin: A Comprehensive Review DOI
Ran Guo, Zhiping Yan,

Rui Wang

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 29, 2025

Epimedium has been widely used in traditional Chinese medicine for several thousands of years. This plant is known tonifying kidney Yang, strengthening muscles and bones, dispelling wind dampness. It worth noting that icaritin, a prenylated flavonoid isolated from Epimedium, received increasing attention recent years due to its wide range pharmacological activities. Icaritin exhibits significant therapeutic potential against various diseases, such as osteoporosis, tumors (hepatocellular carcinoma, stomach cancer, breast glioblastoma), cerebral ischemia skin injury, thrombocytopenia, systemic lupus erythematosus. We review the activities icaritin molecular mechanisms treatment related diseases. The data suggest can have effects mediating Wnt/[Formula: see text]-catenin, IL-6/JAK2/STAT3, AMPK/mTOR, PTEN/AKT, MAPK, NF-[Formula: text]B, other signaling pathways. paper also discusses progress clinical trials icaritin. was approved by State Food Drug Administration January 2022 advanced HCC, drug prospects. Although it some disadvantages, including poor solubility, low bioavailability, still prospective candidate development naturally derived drugs, especially inflammatory aims update deepen understanding provide theoretical basis further study.

Language: Английский

Citations

0
Epimedii Folium flavonoids: A double-edged sword effect on the liver, a dual exploration of efficacy and toxicity DOI Creative Commons

Meijun Yue,

Yanlu Liu,

Xiaoyu Feng

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101269 - 101269

Published: March 1, 2025

Language: Английский

Citations

0
The pathogenesis of hepatocellular carcinoma: ERK/ULK1/NCOA4-mediated inhibition of iron autophagy, and Epimedium extract targeted modulation of this pathway to treat hepatocellular carcinoma DOI
Liying Han, Xun Tian, Xinxin Yang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156666 - 156666

Published: March 1, 2025

Language: Английский

Citations

0