High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1468 - 1468

Published: Nov. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Language: Английский

Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020 DOI Creative Commons
Lian-Zhen Huang,

Zi-Wei Ni,

Qi Yao

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 3, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic worldwide. The pan-immune-inflammation value (PIV) been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding effect of PIV on risk MASLD. This study aimed to investigate association between cross-sectional included 6462 adults aged ≥ 20 years from National Health Nutrition Examination Survey 2017–2020. was calculated based blood count data. Weighted multivariable logistic regression employed calculate odds ratio (OR) 95% confidence interval (CI) Restricted cubic spline (RCS) analysis conducted explore dose-response relationship Stratified sensitivity analyses were performed confirm robustness our findings. Among participants, 2458 diagnosed with Positive associations LnPIV MASLD observed in all three models (Model 1: OR = 1.46, CI: 1.28–1.66, P < 0.001; Model 2: 1.41, 1.24–1.60, 3: 1.39, 1.16–1.65, 0.004). When classified into quartiles, both Q3 Q4 exhibited significantly increased risks compared reference Q1 full adjusted 3 (Q3: 1.63, 1.20–2.22, 0.012; Q4: 1.76, 1.28–2.41, 0.008; trend 0.002). RCS did not show nonlinear (P 0.093 nonlinearity). showed consistent positive subgroups, supported reliability these results. Higher levels are associated an prevalence MASLD, indicating that potentially effective inflammatory marker participants.

Language: Английский

Citations

1
Metabolic Characteristics and Cytokine Gene Polymorphisms as Potential Risk Factors for a Higher Liver Fibrosis Stage in MASLD Patients: A Hospital-Based Study DOI Open Access
Mihaela Iancu, Sorina Cezara Coste, Angela Cozma

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3730 - 3730

Published: April 15, 2025

Polymorphisms in the Toll-like receptor 4 (TLR4) and IL-17 cytokine genes play a role liver fibrosis progression among patients with MASLD. The current study aimed to investigate whether IL17 (A7448G G197A) TLR4 (Asp299Gly Thr399Ile) gene polymorphisms are associated increased stages MASLD patients. Genotyping for IL17F-A7488G, IL17A-G197A, TLR4-Asp299Gly, TLR4-Thr399Ile was performed on sample of 42 39 healthy controls. Serum levels IL17F, IL17A, were measured using ELISA techniques. Bivariate analysis revealed significant associations between glycemic (p = 0.006), lipid metabolism (total cholesterol, HDL triglycerides), severity < 0.05). IL17A-G197A GA AA genotypes more frequent advanced compared those without (GA genotype frequency: 42.9% vs. 7.7%; 14.3% 5.1%; adjusted p 0.0423). In multivariable ordinal logistic regression, polymorphism remained significantly higher (adjusted 0.0155). Patients dominant + AA) exhibited 3.91 times greater odds experiencing at least one-stage increase GG OR 3.91, 95% CI: 1.33–12.34). This indicates that IL17-related genetic metabolic characteristics affect patients, identified as an independent multivariate predictor progression.

Language: Английский

Citations

0
High-Sensitivity C-Reactive Protein Levels in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Alcohol-Associated Liver Disease (MetALD), and Alcoholic Liver Disease (ALD) with Metabolic Dysfunction DOI Creative Commons
Seong‐Uk Baek, Jin‐Ha Yoon

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1468 - 1468

Published: Nov. 18, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a recently introduced term for (SLD). Although the inflammatory process central to pathogenesis of SLD, research investigating differences in systemic inflammation across various SLD subtypes as well sex limited. This population-based, cross-sectional study investigated association between and high-sensitivity C-reactive protein (hs-CRP) levels among Korean adults (N = 20,141; mean age: 50.8 ± 16.7 years). The participants were classified into five groups that included no MASLD, metabolic alcohol-associated (MetALD), alcoholic with dysfunction (ALD MD), other SLDs. median (Q1, Q3) value hs-CRP level was 0.54 mg/L (0.33, 1.04). Among men, compared group, MetALD, ALD MD associated 41.9% (95% confidence interval [CI]: 35.1-49.1%), 46.8% CI: 35.0-59.6%), 51.8% 30.0-77.2%) increases levels, respectively. stronger women, 81.5% 73.6-89.8%), 84.3% 58.1-114.8%), 98.2% 38.0-184.8%) In conclusion, our findings indicate varying profile subtypes, more pronounced women

Language: Английский

Citations

1