Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Despite decades of research, impaired extremity wound healing in type 2 diabetes remains a significant driver patient morbidity, mortality, and health care costs. Advances surgical medical therapies, including the advent endovascular interventions for peripheral artery disease topical therapies developed to promote healing, have not reduced frequency lower leg amputations nonhealing wounds diabetes. This brief report is aimed at reviewing roles various cell types tissue repair summarizing known dysfunctions these diabetic foot ulcers. Recent advances our understanding epigenetic regulation immune cells identified be altered are summarized, particular attention paid developing research defining structural cells, keratinocytes, fibroblasts, endothelial cells. Gaps knowledge highlighted, potential future directions suggested based on current state field.

Language: Английский