N-Acetylcysteine Prevents Ethanol-Induced Neuropathic Pain by Downregulating Nociceptive Activation of Supraspinal Brain Areas Involved in Nociceptive Processing DOI
Natália G. Hösch, Rafael Reis,

Carlos Giovani O. Nascimento

et al.

Published: Jan. 1, 2025

Language: Английский

The Interplay Between Stress and Eating Attitudes: A Cross-Sectional Study Among Romanian Physical Therapy Students DOI Open Access
Corina Sporea, Maria Veronica Morcov, Claudiu Ionuț Vasile

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1755 - 1755

Published: March 5, 2025

Background: University students often experience significant stress, which may contribute to disordered eating behaviors. Objectives: This study examines the relationship between perceived stress and attitudes among physical therapy in Romania, exploring impact on overall well-being identifying predictors of maladaptive patterns. Methods: A cross-sectional survey was conducted with 192 from Faculty Midwifery Nursing, “Carol Davila” Medicine Pharmacy. Two validated instruments were used: Eating Attitudes Test (EAT-26) assess behaviors Perceived Stress Scale (PSS-14) measure levels. Statistical analyses included correlations, ANOVA, regression models, a significance threshold p < 0.05. Results: Among respondents, 15.1% displayed behaviors, significantly correlating EAT-26 subscales. levels predominantly moderate high, younger reporting higher stress. positive correlation found particularly dieting bulimia/food preoccupation. Female reported than males; however, no gender differences observed No associations BMI, weight fluctuations, scores, suggesting other factors better explain Logistic identified as predictor risk, reinforcing its role shaping Conclusions: impacts attitudes, highlighting need for targeted interventions reduce promote healthy coping mechanisms. Future research should investigate longitudinal patterns effectiveness aimed at improving student well-being. The limited sample size absence sensitivity are notable limitations that constrain generalizability findings.

Language: Английский

Citations

0

Parents’ Reflective Functioning, Emotion Regulation, and Health: Associations with Children’s Functional Somatic Symptoms DOI Creative Commons

Aikaterini Fostini,

Foivos Zaravinos-Tsakos,

Gerasimos Kolaitis

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(2), P. 31 - 31

Published: April 3, 2025

Functional somatic symptoms (FSSs) in children—such as headaches, stomachaches, and muscle pain without clear medical explanations—pose a significant clinical challenge, often leading to repeated healthcare visits impairments daily functioning. While the role of parental psychological factors shaping children’s FSSs has been suggested, empirical evidence remains limited fragmented. This study addresses this gap by systematically examining associations between parents’ reflective functioning, emotion regulation, alexithymia, physical mental health, frequency severity FSSs. A total 339 parents children aged 6–12 completed surveys assessing their capacity understand states, regulate emotions, identify or describe feelings, well self-reported health. They also indicated whether child experienced (e.g., stomachaches) more than once per week. Results revealed that with reported significantly lower levels functioning (lower certainty, higher uncertainty), alexithymic traits, greater regulation difficulties, alongside poorer health indices. Logistic regression analyses demonstrated difficulties increased likelihood exhibiting FSSs, while emerged predictor. Furthermore, multiple linear challenges poor predicted These findings offer novel insights into how characteristics can shape symptom expression, highlighting need for family-focused interventions. By identifying addressing emotional cognitive clinicians may be able mitigate intergenerational transmission maladaptive stress responses, ultimately reducing burden children.

Language: Английский

Citations

0

The Effect of Environmental Factors, Health Behaviors, and Psychosocial Aspects on Allergic Diseases in Korean Adolescents DOI Creative Commons

Hwa-jin Lee,

You Hoon Jeon

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 727 - 727

Published: April 14, 2025

Background and Objectives: Adolescence is a critical period of physical mental development, yet allergic diseases are often poorly managed. Factors such as sleep deprivation, obesity, smoking, stress can worsen conditions complicate treatment. This study examines the environmental, behavioral, psychosocial factors influencing in Korean adolescents using data from National Health Nutrition Examination Survey (KNHNES). Materials Methods: From 25,534 participants Fifth KNHNES, 1630 (aged 13–18 years) were selected. We analyzed demographic lifestyle factors, including gender, age, housing type, family size, economic status, tobacco alcohol use, duration, activity. Psychosocial perception, suicidal ideation, depressive symptoms, health counseling, self-rated also examined. Results: The prevalence rates 23% for rhinitis (AR), 11% atopic dermatitis (AD), 9.8% asthma (AS), with 35.8% having at least one condition. Smoking was significantly associated AS (odds ratio [OR] 1.753, p = 0.006), while shorter durations increased AR risk (p 0.000). Male had lower AD (OR 0.706, 0.046), high status inversely correlated 0.445, 0.006). Positive linked to 0.447, male gender 1.391, 0.045), 1.784, 0.026), perception 1.479, 0.013). Conclusions: Low have been identified during adolescence. Integrating counseling medical treatment may improve management outcomes.

Language: Английский

Citations

0

Acute Stress and Autoimmune Markers: Evaluating the Psychoneuroimmunology Axis in Firefighter Recruits DOI Open Access
Andrea Schmitt,

Nathan Andrews,

Koji Yasuda

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3945 - 3945

Published: April 22, 2025

Chronic psychological stress is known to influence immune function and contribute development of autoimmune disorders through dysregulated inflammatory responses. This study investigates relationships between acute stress, life trauma, salivary biomarkers in firefighter recruits during psychophysical training. Salivary samples were collected from two tests evaluate responses stress. Samples obtained at three time points—pre-stress, post-stress, recovery—across both tests. Cortisol was measured characterize response (ASR) profiles, while assessed the analyzing C-reactive Protein (CRP), Complement C4 (C4), Pigment Epithelium Derived Factor (PEDF), Serum Amyloid P (SAP). Results showed significant changes CRP, C4, PEDF after inoculation. Higher previous trauma associated with lower baseline cortisol (r = −0.489) delay recovery 0.514), suggesting a learned biological response, potentially protective against stress-induced dysregulation. Cluster analysis revealed four distinct ASR profiles which found have significantly different past (p 0.031). These findings suggest that history influences biomarker dynamics, reflecting individualized adaptive or maladaptive The insights gained may inform strategies enhance resilience mitigate risk among high-stress populations.

Language: Английский

Citations

0

Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study DOI Creative Commons

Hua Jun Liang,

Q Wu, Shu Yang

et al.

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2191 - 2201

Published: April 1, 2025

Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed investigate whether potential risk factors have causal effect on NP at the genetic level using two-sample Mendelian randomization (MR) analysis. Summary-level data for factors, including distress, anxiety disorder, depression, mood, sleep loneliness, education, alcohol consumption, smoking, time spent computer, and physical activity, as well NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) extracted these datasets. We employed inverse variance weighting (IVW), weighted median, MR-Egger regression methods assess effects. Heterogeneity was evaluated IVW, while horizontal pleiotropy assessed MR-PRESSO analysis regression. The IVW results showed major depressive (OR = 1.51, 95% CI: 1.15, 1.98, p 3.40×10-3) experiencing mood swings 2.73, 1.57, 4.75, 3.86×10-4) positively associated with years of schooling 0.504, 0.410, 0.619, 6.55×10-11) negatively NP. Additionally, loneliness 16.0, 1.29-198, 0.0307) suggestive association As other we did not find clear relationship (All p-values > 0.05). MR provides evidence supporting between swings, association. These findings highlight critical role psychosocial such education level, in prevention management Our may offer new insights clinicians develop targeted intervention strategies reducing incidence

Language: Английский

Citations

0

Choroid plexus volume and association with migraine Pathophysiology DOI

Jianmei Xiong,

Mengqi Liu, Xin Li

et al.

European Journal of Radiology, Journal Year: 2025, Volume and Issue: 188, P. 112135 - 112135

Published: May 2, 2025

Language: Английский

Citations

0

Cognitive implications of white matter microstructural changes in individuals with low heart rate variability: a NODDI study DOI Creative Commons
Shaofan Jiang, Yingzhe Cheng, Ling Luo

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Objective This study aimed to investigated the microstructural integrity of WM and relationship with cognitive domains cognition-related plasma biomarkers in low heart rate variability (HRV). Methods Our recruited 44 high HRV (Grouping by median HF). Diffusion Magnetic resonance imaging (MRI) was utilized for calculation neurite orientation dispersion density (NODDI) parameters, tract-based spatial statistics (TBSS) were employed explore differential clusters. The fibers covered these clusters defined as regions interest (ROI) extraction NODDI parameter values analysis their correlation biomarkers. Results TBSS unveiled specific cerebral exhibiting disparities within group group. These differences evident fractional isotropy (FISO; p &lt; 0.05). extracted from ROIs ( 0.05) mainly manifested anterior brain corpus callosum. Further showed that abnormal white matter (WM) significant correlations CDR, RCFT-I, RCFT-D, attention, memory, language, varying degrees. Conclusion Patients exhibit distinctive patterns changes revealed FISO which indicate a decline integrity, between HRV-related worse performance may be attributed damage frontal-corpus callosum pathways.

Language: Английский

Citations

0

Qifuyin alleviates anxiety and depression in 3×Tg-AD mice by modulating neuroendocrine function DOI Creative Commons

YU Tianhao,

Ying Yu,

Junqi Zhao

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Alzheimer's disease (AD) is frequently accompanied by behavioral and psychological symptoms of dementia (BPSD). Studies have shown that 3×Tg-AD mice, a classical animal model AD, exhibit anxiety depression-like behaviors characteristic BPSD. This study investigated the effects Qifuyin on in mice. The 20 male female C57BL/6 mice at 10.3 months age were used as control group, while 82 same divided into five groups. groups gavaged with solvent, positive medicine group received combination donepezil memantine, (QFY) three doses: low, medium, high. QFY anxiety-like assessed using open field test (OFT) elevated plus maze (EPM) test, evaluated through forced swim (FST) sucrose splash (ST). Plasma levels corticosterone (CORT), testosterone (T), estradiol (E2) measured ELISA, adrenocorticotropic hormone (ACTH), follicle-stimulating (FSH), luteinizing (LH), corticotropin-releasing (CRH), gonadotropin-releasing (GnRH) quantified via radioimmunoassay. Differences plasma among analyzed principal component analysis (PCA). Pearson correlation was conducted to explore relationships between hormones phenotypes, multiple linear regression employed identify most strongly correlated following treatment. In characterized reduced duration, number visits, total distances central area during OFT. EPM revealed duration frequency arms for both sexes. Depression-like evident FST, increased immobility, ST, prolonged grooming latency sexes females. treatment alleviated these behaviors. males, ACTH, GnRH, FSH significantly decreased. QFY-treated CRH reduced, GnRH increased. females, ACTH elevated, LH markedly reduced. CORT decreased, whereas Multiple indicated mainly mitigates modulating males T administration alleviates depression regulating HPA, HPT HPO axes.

Language: Английский

Citations

0

N-Acetylcysteine Prevents Ethanol-Induced Neuropathic Pain by Downregulating Nociceptive Activation of Supraspinal Brain Areas Involved in Nociceptive Processing DOI
Natália G. Hösch, Rafael Reis,

Carlos Giovani O. Nascimento

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0