Therapeutic Advances in Peripheral Nerve Injuries: Nerve-Guided Conduit and Beyond DOI
Changqing Li, Meng Xianyu, S. Li

et al.

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Peripheral nerve injury (PNI), a challenging neurosurgery issue, often leads to partial or complete loss of neuronal functions and even neuropathic pain. Thus far, the gold standard for treating peripheral deficit remains autografts. While numerous reviews have explored PNI regeneration, this work distinctively synthesizes recent advancements in tissue engineering-particularly four-dimensional (4D) bioprinting exosome therapies-with an emphasis on their clinical translation. By consolidating findings spanning molecular mechanisms therapeutic applications, review proposes actionable framework advancing experimental strategies toward clinically viable solutions. Our critically evaluates emerging innovations such as dynamically adaptive 4D-printed conduits exosome-based therapies, underscoring potential match conventional autografts achieving functional restoration. Impact Statement Although several previous been made describing with great detail degenerative regenerative nervous systems, well existing exploratory treatment strategies, we focus more latest each those topics.

Language: Английский

The Evolution of Thermoplastic Raw Materials in High-Speed FFF/FDM 3D Printing Era: Challenges and Opportunities DOI Open Access
Antreas Kantaros,

Meropi Katsantoni,

Theodore Ganetsos

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1220 - 1220

Published: March 9, 2025

The evolution of thermoplastic materials has played a critical role in advancing high-speed Fused Filament Fabrication (FFF) and Deposition Modeling (FDM) 3D printing technologies. This study explores the performance challenges associated with next-generation thermoplastics specifically designed for printing, such as PLA, ABS, PETG, comparison to conventional materials. A systematic analysis was conducted evaluate key parameters, including mechanical properties, layer adhesion, surface finish, dimensional accuracy, under varying conditions. results reveal that thermoplastics, when coupled advanced hardware optimized motion control systems, achieve up 70% reduction time without significant trade-offs integrity or precision. Additionally, identifies challenges, increased thermal stresses, warping, need precise cooling strategies, which can impact material at elevated speeds. Opportunities future development are also discussed, design novel polymer formulations innovations further enhance reliability scalability FFF/FDM printing. work underscores potential adopting era highlights interplay between science engineering achieving manufacturing capabilities.

Language: Английский

Citations

1
New Trends in 3D and 4D Printed Dental and Orthopedic Implants:Methods, Applications and Future Directions DOI
Amirhossein Moghanian, Parviz Asadi, Mostafa Akbari

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00406 - e00406

Published: March 1, 2025

Language: Английский

Citations

0
Vat Photopolymerization-Based Additive Manufacturing of Si3N4 Ceramic Structures: Printing Optimization, Debinding/Sintering, and Applications DOI Open Access
Ziheng Wang,

Yun-Zhuo Zhang,

Wei Miao

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(7), P. 1556 - 1556

Published: March 29, 2025

Si3N4 ceramics and composites stand out for their exceptional mechanical thermal properties. Compared with conventional ceramic forming processes, 3D printing via vat photopolymerization not only ensures high geometric precision but also improves the efficiency strength of green body. Nevertheless, grayish appearance its relatively refractive index can adversely affect photocuring behavior in slurries. The primary objectives focus on enhancing curing performance rheological properties slurries, minimizing defects during post-processing, improving relative density ceramics. Key advancements include slurry optimization matching, biomodal particle gradation surface modification, while integration whisker/fiber additions or polymer-derived strategies enhances In addition, controlling atmosphere heating rate post-processing innovations achieve a more than 95%. This paper introduces mechanisms then summarizes slurries as well debinding/sintering processes. It further highlights ways which different approaches be used to enhance parts. Finally, applications various fields such aviation, aerospace, energy, electronics, chemical biomedical implants are presented point future opportunities challenges.

Language: Английский

Citations

0
Therapeutic Advances in Peripheral Nerve Injuries: Nerve-Guided Conduit and Beyond DOI
Changqing Li, Meng Xianyu, S. Li

et al.

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Peripheral nerve injury (PNI), a challenging neurosurgery issue, often leads to partial or complete loss of neuronal functions and even neuropathic pain. Thus far, the gold standard for treating peripheral deficit remains autografts. While numerous reviews have explored PNI regeneration, this work distinctively synthesizes recent advancements in tissue engineering-particularly four-dimensional (4D) bioprinting exosome therapies-with an emphasis on their clinical translation. By consolidating findings spanning molecular mechanisms therapeutic applications, review proposes actionable framework advancing experimental strategies toward clinically viable solutions. Our critically evaluates emerging innovations such as dynamically adaptive 4D-printed conduits exosome-based therapies, underscoring potential match conventional autografts achieving functional restoration. Impact Statement Although several previous been made describing with great detail degenerative regenerative nervous systems, well existing exploratory treatment strategies, we focus more latest each those topics.

Language: Английский

Citations

0