Development of Molecularly Imprinted Polymer−Based Electrochemical Sensor for Sensitive Detection of Pirfenidone DOI
Özge Selcuk, Bengi Uslu

Published: Jan. 1, 2023

In this study, the electrochemical determination of pirfenidone (PIR), an antifibrotic drug, was developed for first time with a bare glassy carbon electrode (GCE) and molecularly imprinted sensor. A stable selective sensor designed detection PIR in modified molecular polymer chitosan (CHIT), ionic liquid (IL), diamond nanoparticle (DiaNPs) (MIP/CHIT@IL@DiaNPs/GCE). Two steps were applied to perform imprinting process: (1) adsorption o−PD surface during polymerization ortho−phenylenediamine(o−PD) monomer onto GCE, (2) extraction from template. The MIP/CHIT@IL@DiaNPs/GCE characterized by impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscopy (SEM). K3[Fe(CN)6]/K4[Fe(CN)6] redox couple used as probe characterize using voltammetric differential pulse methods. Parameters affecting response such composition CHIT@IL@DiaNPs suspension, concentration electropolymerization solution, number cycles, optimization removal solution time, binding optimized. Under optimum conditions, PIR, GCE showed linear range 9.90 μM 260.0 limit calculated be 2.48 μM, while MIP exhibited good sensitivity 30.0 pM−1.0 nM 9.29 nM. To demonstrate applicability sensors real samples, made Pirfect® tablet human serum. selectivity sensor, which is one most important validation parameters analytical methods, producing nonimprinted electrode, factor found 5.81.

Language: Английский

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples DOI Creative Commons
Sumeet Malik, Adnan Khan, Hamayun Khan

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(4), P. 429 - 429

Published: March 28, 2023

Magnetic molecularly imprinted polymers (MMIPs) contain the predesigned specialized recognition capability that can be chosen to build credible functional materials, are easy handle and have a good degree of specificity. Hence, given piece work is intended design novel electrochemical sensor incorporating magnetite-based polymers. The building materials consisted cross-linker (EGDMA), reaction-initiator (AIBN), monomer (methylene succinic acid-MSA), template molecule (Sunset Yellow-SY dye). MMIPs exhibited diameter 57 nm with an irregular shape due presence cavities based on SEM analysis. XRD patterns crystallinity, as well amorphous peaks attributed polymeric non-polymeric frameworks MMIPs. crystallite size from analysis was found 16.28 Debye-Scherrer's equation. Meanwhile, FTIR bands showed synthesis using methylene acid. sorption data at optimized operating conditions (pH 2, sorbent dosage 3 mg, time 18 min) highest capacity 40 mg/g. obtained best fitted Langmuir isotherm followed pseudo-second-order kinetics. magneto-sensors were applied for ultrasensitive, rapid, simple sensing SY dye. experiments run condition range (scan rate 10-50 mV/s, tads 0-120 s, pH 5-9, potential 1-1.5 V CV 1-1.3 SWAdASV). linear detection set 1.51 × 10-6 M posing LOD LOQ values 8.6242 10-5 0.0002874 M, respectively. regression value calibration 0.950. Additionally, high adsorption efficiency, selectivity, reusability, strong structural stability use in real samples. These characteristics make viable substrate chemical contaminants environment health-related products.

Language: Английский

Citations

15
Electrochemical detection of caffeine in sports drinks based on molecular imprinting technology DOI
Huan Li, Dongmei Wei

Journal of Food Measurement & Characterization, Journal Year: 2024, Volume and Issue: 18(5), P. 3577 - 3583

Published: March 15, 2024

Language: Английский

Citations

5
Dual-Mode Nanosensor for Sensitive Detection of Methotrexate Based on Fluorescence Technology and Deep Learning Algorithms DOI

Chenyue Kang,

Yueying Li, Yan Zhang

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1362, P. 344190 - 344190

Published: May 14, 2025

Language: Английский

Citations

0
Designing A Selective Electrochemical Nanosensor Based on Molecularly Imprinted Polymer for Detection of Pirfenidone DOI Creative Commons
Özge Selcuk, Bengi Uslu

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(8), P. 087505 - 087505

Published: Aug. 1, 2024

In this study, an electrochemical determination of pirfenidone(PIR), antifibrotic drug, was developed for the first time with a bare glassy carbon electrode(GCE) and molecularly imprinted polymer(MIP)-based nanosensor. A polymer(MIP) incorporating o-phenylenediamine(o-PD), chitosan(CHIT), ionic liquid(IL), diamond nanoparticles(DiaNPs) utilized to modify electrode(GCE), developing stable selective nanosensor(MIP/CHIT@IL@DiaNPs/GCE) PIR detection. The designed MIP/CHIT@IL@DiaNPs/GCE characterized by impedance spectroscopy(EIS), cyclic voltammetry(CV), scanning electron microscopy(SEM) atomic force microscopy(AFM). [Fe(CN) 6 ] 3−/4− redox couple used as probe characterize nanosensor using voltammetric methods. Under optimum conditions, GCE showed linear response in concentration range 9.90 μM 260.0 PIR, detection limit calculated be 2.48 μM. While, exhibited good sensitivity 30.0 pM−1.0 nM 9.29 pM. To demonstrate applicability nanosensors real samples, made from Pirfect® tablet human serum.

Language: Английский

Citations

3
Electrochemical Analysis of Curcumin in Real Samples Using Intelligent Materials DOI Open Access
Eduardo Jara-Cornejo, Erick Peña-Bedón,

Mahely Torres Moya

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(3), P. 366 - 366

Published: Jan. 29, 2024

Curcumin is a compound of great importance in the food industry due to its biological and pharmacological properties, which include being an antioxidant, anti-inflammatory, antibacterial, antiviral, anticarcinogenic. This paper proposes synthesis electrochemical sensor based on molecularly imprinted polymers (MIPs) MWCNT by drop casting deposited glassy carbon electrode (GCE) for selective quantification curcumin samples. The synthesized compounds are characterized Fourier transform infrared (IR), Brunauer–Emmett–Teller (BET), techniques such as cyclic voltammetry (CV) differential pulse (DPV). optimal conditions further experiments were determined selecting these parameters. We examined three products, commercial capsules, turmeric rhizomes, powder, employing both HPLC methods analysis. method revealed limit detection (LOD) value 0.1365 µmol L−1, compared with analysis, gave 3.55 L−1. Furthermore, MIP material demonstrated superior selectivity analyte potential interferents. recovery percentage, using method, fell within range 87.5% 102.6%

Language: Английский

Citations

2
The Alphabet of Nanostructured Polypyrrole DOI Open Access
Sylwia Golba, Jan Loskot

Materials, Journal Year: 2023, Volume and Issue: 16(22), P. 7069 - 7069

Published: Nov. 7, 2023

This review is devoted to polypyrrole and its morphology, which governs the electroactivity of material. The macroscopic properties material are strictly relevant microscopic ordering observed at local level. During synthesis, various (nano)morphologies can be produced. formation ordered structure dictated by ability forces effects induce restraints that help shape structure. covers aspects morphology roughness their impact on final modified electrode activity in selected applications.

Language: Английский

Citations

2
Ultrasensitive electrochemical (bio)sensors for therapeutic drug monitoring DOI Creative Commons
Miruna David, Monica Florescu

Current Opinion in Electrochemistry, Journal Year: 2024, Volume and Issue: 46, P. 101501 - 101501

Published: April 1, 2024

Ultrasensitive detection is important for the individualized management of medical therapy, playing a key role improvement life expectancy and quality life. Implementing personalized medicine represents complex challenge since it requires development new, simple, versatile, sustainable technologies which offer real-time, accurate reliable outputs. With increasing chronic conditions cancers, but also excessive use abuse medication, there strong need continuous monitoring therapeutic drugs to prevent toxicity levels in case overdose, or inefficiency underdose. However, date, only few easy-to-use systems are available trace analysis help physicians patients drug monitoring. Here, we critically evaluate recent advances highlighting position electrochemical (bio)sensors on roadmap towards ultrasensitive therapy.

Language: Английский

Citations

0
Molecularly Imprinted Polymers as Highly Selective Sorbents in Sample Preparation Techniques for Extracting Emerging Pollutants from Environmental Water DOI
Nur Nadhirah Mohamad Zain, Nor Munira Hashim, Noorfatimah Yahaya

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Electrochemical sensors DOI
Gulsu Keles, Aysel Oktay,

Pakize Aslan

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 225 - 270

Published: Jan. 1, 2024

Citations

0
Development of Molecularly Imprinted Polymer−Based Electrochemical Sensor for Sensitive Detection of Pirfenidone DOI
Özge Selcuk, Bengi Uslu

Published: Jan. 1, 2023

In this study, the electrochemical determination of pirfenidone (PIR), an antifibrotic drug, was developed for first time with a bare glassy carbon electrode (GCE) and molecularly imprinted sensor. A stable selective sensor designed detection PIR in modified molecular polymer chitosan (CHIT), ionic liquid (IL), diamond nanoparticle (DiaNPs) (MIP/CHIT@IL@DiaNPs/GCE). Two steps were applied to perform imprinting process: (1) adsorption o−PD surface during polymerization ortho−phenylenediamine(o−PD) monomer onto GCE, (2) extraction from template. The MIP/CHIT@IL@DiaNPs/GCE characterized by impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscopy (SEM). K3[Fe(CN)6]/K4[Fe(CN)6] redox couple used as probe characterize using voltammetric differential pulse methods. Parameters affecting response such composition CHIT@IL@DiaNPs suspension, concentration electropolymerization solution, number cycles, optimization removal solution time, binding optimized. Under optimum conditions, PIR, GCE showed linear range 9.90 μM 260.0 limit calculated be 2.48 μM, while MIP exhibited good sensitivity 30.0 pM−1.0 nM 9.29 nM. To demonstrate applicability sensors real samples, made Pirfect® tablet human serum. selectivity sensor, which is one most important validation parameters analytical methods, producing nonimprinted electrode, factor found 5.81.

Language: Английский

Citations

0