THE ROLE OF BIOCERAMICS IN MODERN DENTISTRY: FROM EARLY INNOVATIONS TO FUTURE DIRECTIONS DOI Creative Commons

Diana Hanu,

Sorina Mihaela Solomon,

Sorina Paduraru

et al.

Published: Sept. 15, 2024

The use of bioceramics in modern dentistry has significantly evolved, offering enhanced clinical outcomes various procedures. This article reviews the development and application bioceramic materials, focusing on their biocompatibility, ability to stimulate tissue regeneration, chemical stability. Notable materials such as Mineral Trioxide Aggregate (MTA) Biodentine are highlighted for role endodontic treatments bone regeneration. paper also discusses innovations synthesis functionalization bioceramics, including doping with elements integration nanotechnology, which have led advancements faster setting times improved antimicrobial properties. Furthermore, provides a historical perspective transition from early bioactive like hydroxyapatite, emphasizing impact implantology future directions potential regenerative medicine activity, explored.

Language: Английский

The critical role of nano-hydroxyapatites as an advanced scaffold in drug delivery towards efficient bone regeneration: Recent progress and challenges DOI Creative Commons

Amir Hatami kaleshtari,

Samira Farjaminejad,

Melika Hasani

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100692 - 100692

Published: Jan. 1, 2025

Language: Английский

Citations

2
Nacre-like structural carboxymethyl cellulose dual-layered film with a combination of high strength, elongation, and UV-blocking for food packaging DOI
Zhiping Wang

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141692 - 141692

Published: March 4, 2025

Language: Английский

Citations

0
P24 Loaded Gelatin‐Hydroxyapatite‐Tricalcium Phosphate Scaffold Induces Bone Regeneration by Activating the ERK/ELK1/PLA2G3 Pathway DOI

Laihua Fu,

Yuanxin Liu, Songfeng Xu

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(4)

Published: April 1, 2025

ABSTRACT The study examined the induction and mechanism of bone regeneration facilitated by P24‐loaded Gelatin‐Hydroxyapatite‐Tricalcium Phosphate (Gelatin‐HA‐TCP (P24)) scaffold. prepared Gelatin‐HA‐TCP (P24) scaffold was employed to treat human marrow mesenchymal stem cells (hBMSCs) umbilical vein endothelial (HUVECs). Various assays were conducted assess impact on osteogenic differentiation hBMSCs angiogenesis in HUVECs. For mechanistic investigations, exposed both ERK inhibitor SCH772984. A rat cranial defect model treated through implantation Micro‐computed tomography, histological staining, immunofluorescence techniques utilized evaluate effect regeneration. Osteogenic scaffold, as evidenced increased ALP activity, enhanced Alizarin Red S upregulated RUNX2, OSX, OCN, BMP2. Angiogenesis HUVECs induced, demonstrated improved migration, tube formation, CD31. However, ability promote counteracted In model, reduced area, volume/tissue volume ratio, regeneration, decreased fibrosis, CD31, BMP2 tissues. Therefore, enhances promotes defects activating ERK/ELK1/PLA2G3 pathway. It has potential for therapies.

Language: Английский

Citations

0
Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation DOI Open Access

Santos Júnior,

Letícia Carlucci dos Santos,

Daniela Vieira Buchaim

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1704 - 1704

Published: April 9, 2025

Different treatments have been proposed for morphofunctional bone repair; however, they are not always efficient and limitations. In this experimental study, we present matrix composites with a possible synergistic effect acting scaffolds growth use of photobiomodulation (PBM) to accelerate tissue repair. Thus, the objective was evaluate PBM in repair long (tibia) rats filled biomimetic collagen matrices nanohydroxyapatite heterologous fibrin biopolymer (FB). Forty-eight were distributed into eight groups (n = six each): Blood Clot (BC), + (BCP), Matrix (M), (MP), Fibrin Biopolymer (FB), (FBP), FB (MFB), (MFBP). A 2.0 mm defect created proximal third left tibia. The BCP, MP, FBP, MFBP underwent during surgery maintained twice week until euthanasia at 42 days. Microcomputed tomography (micro-CT), histomorphological histomorphometric analyses performed. Micro-CT analysis revealed that influenced cortical interposition between remnant newly formed bone. Histologically, no exacerbated inflammatory focus or foreign body-type granulomatous reaction observed any group; vast collagenous more oriented thicker spatial conformation PBM-treated groups. Histomorphometrically, showed significantly higher values compared other Specifically, BC group presented mean density 68.33 ± 7.394, while BCP MP 99.83 11.87 99.67 20.58, respectively (p < 0.05). Qualitative fibers indicated enhanced organization maturation This study concluded association bones rats, biopolymer, results contribute improvement growth, together scaffolds.

Language: Английский

Citations

0
Three-Dimensional-Printed Bone Grafts for Simultaneous Bone and Cartilage Regeneration: A Promising Approach to Osteochondral Tissue Engineering DOI Creative Commons
Smiljana Paraš, Božana Čolović, Dijana Mitić

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 489 - 489

Published: April 8, 2025

Background/Objectives: A novel 3D-printed, bioresorbable bone graft, made of nanohydroxyapatite (nHAP) covered by poly(lactide-co-glycolide) (PLGA), showed strongly expressed osteoinductive properties in our previous investigations. The current study examines its application the dual regeneration and cartilage combining with nHAP gel obtained enrichment hydroxyethyl cellulose, sodium hyaluronate, chondroitin sulfate. Methods: In vitro part study, mitochondrial activity osteogenic chondrogenic differentiation stem cells derived from apical papilla (SCAPs) presence were investigated. For vivo three rabbits underwent segmental osteotomies lateral condyle femur, defects filled 3D-printed grafts customized to defect geometry. Results: revealed that displayed significant biocompatibility, substantially increasing facilitating SCAPs. after a 12-week healing period, partial resorption graft was observed, lamellar tissue Haversian systems detected. Histological stereological evaluations implanted indicated successful regeneration, marked infiltration new cartilaginous into graft. existence osteocytes increased vascularization active osteogenesis. hyaline near numerous chondrocytes layer newly formed cartilage. Conclusions: This demonstrated tailored could efficiently promote substantial formation without requiring supplementary biological factors, offering feasible alternative for clinical repair applications.

Language: Английский

Citations

0
Recent Advances in Biomaterial‐Based Scaffolds for Guided Bone Tissue Engineering: Challenges and Future Directions DOI

Akshay Tupe,

Vinita Patole, Ganesh Ingavle

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(11)

Published: Nov. 1, 2024

ABSTRACT Bone tissue engineering (BTE) has emerged as a promising approach for the regeneration and repair of bone defects caused by trauma, disease, or aging. This review provides an overview recent advancements in BTE, with focus on development application biomaterial‐based scaffolds, including natural (e.g., collagen, chitosan), synthetic polylactic acid [PLA], polycaprolactone [PCL]), composite materials hydroxyapatite‐based composites). It discusses their properties, benefits, limitations. Additionally, this examines innovative fabrication strategies such 3D printing, electrospinning, freeze‐drying, which enhance scaffold customization performance. aims to provide insights into future directions BTE research its potential applications regenerative medicine. Functionalization strategies, surface modifications, coating, incorporation growth factors cells, are reviewed roles improving bioactivity. In vivo vitro have demonstrated therapeutic promise these while current clinical trials offer translational use. Challenges facing translation technologies practice also highlighted.

Language: Английский

Citations

1
Wet chemical synthesis of nanohydroxyapatite within poly(sodium sulfonated butylene fumarate‐co‐acrylic acid) as bone scaffold: effects of sulfonate and carboxylic acid groups DOI Open Access

Nadia Mahmoudzadeh,

Hadi Shirali, Faramarz Afshar Taromi

et al.

Polymer International, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract This study investigates the synthesis, nucleation and modification of biodegradable poly(sodium sulfonated butylene fumarate‐ co ‐acrylic acid)/hydroxyapatite nanocomposite scaffolds for bone tissue engineering, with a focus on effects incorporating hydrophilic sulfonate carboxylic acid groups. Poly(butylene fumarate) was at varying degrees used to form nanocomposites through in situ nanohydroxyapatite (nHA) simulated body fluid solution. Critical parameters such as water absorption, swelling behavior, mechanical properties, nanoparticle dispersion biocompatibility were evaluated. Water uptake ratios ranged from 2.72 6.88 g −1 , while compressive modulus values increased up 25.9 times compared corresponding homopolymers, demonstrating improved stability. Despite formation over 80% nanoparticles, well‐distributed nHA, sizes averaging 39 ± 13 nm, achieved incorporation groups, preventing agglomeration within scaffold matrix. Additionally, supported human dermal fibroblast adhesion proliferation, cell viability remaining high throughout culture period. These results suggest that developed offer enhanced biocompatibility, strength osteogenic potential, making them promising candidates regeneration applications. © 2024 Society Chemical Industry.

Language: Английский

Citations

0
THE ROLE OF BIOCERAMICS IN MODERN DENTISTRY: FROM EARLY INNOVATIONS TO FUTURE DIRECTIONS DOI Creative Commons

Diana Hanu,

Sorina Mihaela Solomon,

Sorina Paduraru

et al.

Published: Sept. 15, 2024

The use of bioceramics in modern dentistry has significantly evolved, offering enhanced clinical outcomes various procedures. This article reviews the development and application bioceramic materials, focusing on their biocompatibility, ability to stimulate tissue regeneration, chemical stability. Notable materials such as Mineral Trioxide Aggregate (MTA) Biodentine are highlighted for role endodontic treatments bone regeneration. paper also discusses innovations synthesis functionalization bioceramics, including doping with elements integration nanotechnology, which have led advancements faster setting times improved antimicrobial properties. Furthermore, provides a historical perspective transition from early bioactive like hydroxyapatite, emphasizing impact implantology future directions potential regenerative medicine activity, explored.

Language: Английский

Citations

0