Biosensors, Journal Year: 2024, Volume and Issue: 14(8), P. 389 - 389
Published: Aug. 12, 2024
This study investigates the oxygen (O2) consumption of single cells during changes in their migration direction. is first integration nanotopographies with an O2 biosensor a platform, allowing real-time monitoring and ability to distinguish migrating same direction from those opposite Advanced nanofabrication technologies were used pattern nanoholes or nanopillars on grating ridges, effects evaluated using fluorescence microscopy, cell assays, analysis. The results revealed that over ridges exhibited enhanced motility more frequent directional changes. Additionally, these showed increased number protrusions filopodia denser F-actin areas dotted structures around nanopillars. Dynamic metabolic responses also evident, as indicated by intensity peaks platinum octaethylporphyrin ketone dye, reflecting higher mitochondria activities, due energy required response emphasizes complex interplay between changes, providing insights into biomaterial science regenerative medicine. It suggests innovative designs for biomaterials guide metabolism, advocating nanoengineered platforms harness intricate relationships microenvironments therapeutic applications.
Language: Английский