BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
The
fields
of
tissue
engineering
and
regenerative
medicine
have
made
astounding
progress
in
recent
years,
evidenced
by
cutting‐edge
4D
printing
technologies,
precise
gene
editing
tools,
sustained
long‐term
functionality
engineered
grafts.
Despite
these
fantastic
feats,
the
clinical
success
tissue‐engineered
constructs
so
far
remains
limited
to
only
those
relatively
simple
types
tissues
such
as
thin
bilayer
skin
equivalents
or
avascular
cartilage.
On
other
hand,
volumetric
(larger
than
a
few
millimeters
all
dimensions),
which
are
highly
desirable
for
utility,
suffer
from
poor
oxygen
supply
due
dimensional
diffusion.
Notably,
large,
complex
typically
require
vascular
network
growing
cells
with
nutrients
metabolic
demands
prolong
viability
support
formation.
In
recognition,
extensive
efforts
been
create
vascular‐like
networks
order
facilitate
mass
exchange
through
scaffolds.
This
review
underlines
urgent
need
continued
research
more
functional
networks,
is
crucial
generating
viable
tissues,
highlights
advances
sacrificial
template‐enabled
formation
networks.
Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
ABSTRACT
Osteochondral
damage,
caused
by
trauma,
tumors,
or
degenerative
diseases,
presents
a
major
challenge
due
to
the
limited
self‐repair
capacity
of
tissue.
Traditional
treatments
often
result
in
significant
trauma
and
unpredictable
outcomes.
Recent
advances
bone/cartilage
tissue
engineering,
particularly
scaffold
materials
fabrication
technologies,
offer
promising
solutions
for
osteochondral
regeneration.
This
review
highlights
selection
design
scaffolds
using
natural
synthetic
such
as
collagen,
chitosan
(Cs),
polylactic
acid
(PLA),
alongside
inorganic
components
like
bioactive
glass
nano‐hydroxyapatite
(nHAp).
Key
techniques—freeze‐drying,
electrospinning,
3D
printing—have
improved
porosity
mechanical
properties.
Special
focus
is
placed
on
multiphasic
that
mimic
structures,
promoting
cell
adhesion
differentiation
supporting
regeneration
cartilage
subchondral
bone.
In
addition,
current
obstacles
future
directions
regenerating
damaged
tissues
will
be
discussed.
Orthopedic Research and Reviews,
Journal Year:
2025,
Volume and Issue:
Volume 17, P. 105 - 113
Published: March 1, 2025
Tendon
healing
after
ligament
or
tendon
reconstruction
remains
a
significant
challenge.
Regenerative
tissue
engineering,
an
interdisciplinary
field
that
combines
biology,
materials
science,
and
offers
promising
solutions.
Recent
developments
have
introduced
scaffold
designed
to
enhance
the
proliferation
differentiation
of
tendon-to-bone
cells.
These
scaffolds
possessing
three-dimensional
composites
cells
biomaterials,
proven
effective
in
facilitating
curing
post-surgery.
The
successful
development
interface
is
critical
factor
for
early
rehabilitation
functional
recovery.
In
this
mini-review,
we
present
comprehensive
update
on
contemporary
strategies
synthetic
scaffold-based
their
influence
healing.
We
described
compositions,
structures
features
single-layer,
multi-layer,
gradient
with
special
mechanical
properties.
examined
construction
engineering
from
perspectives
biomaterials
design
strategies,
providing
evaluation
advantages
disadvantages
associated
each
approach.
Ultimately,
review
articulates
clear
research
directions
aimed
at
achieving
breakthroughs
future
studies.
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Highly
porous,
rigid
cellulose
gels
were
developed
through
a
novel
process
involving
the
slow
hydrolysis
of
acetyl
groups
in
acetate
directly
an
acetone/aqueous
ammonia
solution.
Journal of Biomedical Materials Research Part A,
Journal Year:
2025,
Volume and Issue:
113(4)
Published: April 1, 2025
ABSTRACT
Bacterial
cellulose
(BC)
has
emerged
as
a
highly
versatile
and
promising
biomaterial
in
tissue
engineering,
with
potential
applications
across
skin,
bone,
cartilage,
vascular
regeneration.
Its
exceptional
properties
like
high
mechanical
strength,
superior
biocompatibility,
excellent
moisture
retention,
inherent
ability
to
support
cell
adhesion
proliferation,
make
BC
particularly
effective
for
wound
healing
skin
These
attributes
accelerate
repair
foster
new
formation,
highlighting
its
value
skin‐related
applications.
Additionally,
BC's
capacity
osteogenic
differentiation,
combined
robustness,
positions
it
strong
candidate
bone
facilitating
regeneration
repair.
Recent
advancements
have
emphasized
the
development
of
BC‐based
hybrid
scaffolds
enhance
tissue‐specific
functionalities,
including
vascularization
cartilage
innovations
aim
address
complex
requirements
various
engineering
However,
challenges
remain,
regarding
scalability
production,
cost‐effectiveness,
long‐term
stability
scaffolds.
Such
barriers
continue
limit
broader
clinical
adoption.
This
review
critically
examines
synthesis
methods,
intrinsic
properties,
recent
design
scaffolds,
offering
insights
into
their
revolutionize
regenerative
medicine.
Furthermore,
addresses
key
limitations
that
must
be
overcome
enable
integration
BC.
By
addressing
these
limitations,
could
play
transformative
role
advancing
therapies,
bridging
gap
between
laboratory
research
application.
