An Update on Recent Treatment Approaches for Prostate Cancer DOI

Atefeh Bijanvand,

Sheyda Khalilian, Amir Hossein Loghman

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: Jan. 1, 2024

Language: Английский

Potential Therapeutic Use of Aptamers against HAT1 in Lung Cancer DOI Open Access
José Ignacio Klett-Mingo, Celia Pinto‐Díez,

Julio Cambronero-Plaza

et al.

Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 227 - 227

Published: Dec. 30, 2022

Lung cancer is one of the leading causes death worldwide and most common all types. Histone acetyltransferase 1 (HAT1) has attracted increasing interest as a potential therapeutic target due to its involvement in multiple pathologies, including cancer. Aptamers are single-stranded RNA or DNA molecules whose three-dimensional structure allows them bind molecule with high specificity affinity, thus making exceptional candidates for use diagnostic tools. In this work, aptamers against HAT1 were obtained, subsequently characterized, optimized, showing affinity ability inhibit activity vitro. Of those tested, apHAT610 aptamer reduced cell viability, induced apoptosis cycle arrest, inhibited colony formation lung lines. All these results indicate that drug treatment

Language: Английский

Citations

6
A fluorescent probe for protein tyrosine kinase 7 detection in serum and cell imaging DOI Creative Commons
Lujia Shi, Yu Ma,

Huaiyin Zhang

et al.

Talanta, Journal Year: 2022, Volume and Issue: 254, P. 124139 - 124139

Published: Nov. 26, 2022

Language: Английский

Citations

4
A novel aptamer agent showed antidepressant function via binding 5-hydroxytryptamine receptor to block re-uptake of 5-HT DOI Open Access

Zhiding Shao,

Renrui Han, Ying Hua

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 29(1), P. 237 - 247

Published: March 1, 2024

Background & Objectives: Systematic evolution of ligands by exponential enrichment (SELEX) technology was widely used to screen the aptamers that bind target protein safely and efficiently. Our study aimed for anti-depression via binding 5-HTR block 5-HT re- uptake. Methods: The prokaryotic expression plasmid constructed recombinant 5-HT1AR (mice) expressed purified. ssDNA aptamer bound specifically screened SELEX (Enzyme-linked Oligonucleotide assay), sites relative strength were detected. At same time, inhibitory uptake against depression verified in cellular level mouse model. Results: purified successfully. After 12 rounds positive screening 5 negative screening, four with high affinity specificity obtained epitope bounded using ELONA assay). influenced 18 vitro, improvement state mice after intravenous injection proved tail suspension experiment mice. Conclusions: Aptamer is expected be a new type antidepressant, which can treatment depression.

Language: Английский

Citations

0
Noninvasive Photothermal Therapy of Nasopharyngeal Cancer Guided by High Efficiency Optical-Absorption Nanomaterial Enhanced by NIR-II Photoacoustic Imaging DOI Creative Commons
Zhaoyong Li,

Yanping Lin,

Ting Qiu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7817 - 7830

Published: July 1, 2024

Photothermal therapy (PTT) guided by photoacoustic imaging (PAI) using nanoplatforms has emerged as a promising strategy for cancer treatment due to its efficiency and accuracy. This study aimed develop synthesize novel second near-infrared region (NIR-II) absorption-conjugated polymer acceptor acrylate-substituted thiadiazoloquinoxaline-diketopyrrolopyrrole polymers (PATQ-DPP) designed specifically photothermal contrast agents nasopharyngeal carcinoma (NPC).

Language: Английский

Citations

0
An Update on Recent Treatment Approaches for Prostate Cancer DOI

Atefeh Bijanvand,

Sheyda Khalilian, Amir Hossein Loghman

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: Jan. 1, 2024

Language: Английский

Citations

0