Recent Progress in Saliva-Based Sensors for Continuous Monitoring of Heavy Metal Levels Linked with Diabetes and Obesity DOI Creative Commons
Liliana Anchidin-Norocel, Wesley K. Savage, Alexandru Nemţoi

et al.

Chemosensors, Journal Year: 2024, Volume and Issue: 12(12), P. 269 - 269

Published: Dec. 19, 2024

Sensors are versatile technologies that provide rapid and efficient diagnostic results, making them invaluable tools in public health for measuring monitoring community exposure to environmental contaminants. Heavy metals such as lead, mercury, cadmium, commonly found food water, can accumulate the body have toxic effects, contributing development of conditions like obesity diabetes. Traditional methods detecting these often require invasive blood samples; however, sensors utilize saliva, offering a noninvasive simplified approach screening. The use saliva fluid represents major advance population due its low cost, noninvasiveness, ease collection. Recent advances sensor technology enabled tests link heavy metal levels with risk developing Optimizing could facilitate identification individuals or groups at risk, enabling targeted, personalized preventive measures. hold promise diagnosing preventing metabolic diseases, providing valuable insights into between health.

Language: Английский

Resveratrol attenuates high glucose-induced inflammation and improves glucose metabolism in HepG2 cells DOI Creative Commons
Abegail Mukhethwa Tshivhase, Tandi E. Matsha, Shanel Raghubeer

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 11, 2024

Abstract Diabetes mellitus (DM) is characterized by impaired glucose and insulin metabolism, resulting in chronic hyperglycemia. Hyperglycemia-induced inflammation linked to the onset progression of diabetes. Resveratrol (RES), a polyphenol phytoalexin, studied diabetes therapeutics research. This study evaluates effect RES on metabolism HepG2 cells exposed high glucose. Inflammation metabolism-related genes were investigated using qPCR. Further, inflammatory analyzed applying ELISA Bioplex assays. High significantly increases IKK-α, IKB-α, NF-kB expression compared controls. Increased was followed increased pro-inflammatory cytokines, such as TNF-α, IL-6, IL-β, COX2. treatment reduced NF-kB, well cytokines. levels TGFβ1, while with TGFβ1. As increased, PEPCK reduced, GCK treated RES. cultured showed significant KLF7 HIF1A but decreased SIRT1. Moreover, SIRT1 levels. Our results indicated that could attenuate glucose-induced enhance cells.

Language: Английский

Citations

14
Recent Progress in Saliva-Based Sensors for Continuous Monitoring of Heavy Metal Levels Linked with Diabetes and Obesity DOI Creative Commons
Liliana Anchidin-Norocel, Wesley K. Savage, Alexandru Nemţoi

et al.

Chemosensors, Journal Year: 2024, Volume and Issue: 12(12), P. 269 - 269

Published: Dec. 19, 2024

Sensors are versatile technologies that provide rapid and efficient diagnostic results, making them invaluable tools in public health for measuring monitoring community exposure to environmental contaminants. Heavy metals such as lead, mercury, cadmium, commonly found food water, can accumulate the body have toxic effects, contributing development of conditions like obesity diabetes. Traditional methods detecting these often require invasive blood samples; however, sensors utilize saliva, offering a noninvasive simplified approach screening. The use saliva fluid represents major advance population due its low cost, noninvasiveness, ease collection. Recent advances sensor technology enabled tests link heavy metal levels with risk developing Optimizing could facilitate identification individuals or groups at risk, enabling targeted, personalized preventive measures. hold promise diagnosing preventing metabolic diseases, providing valuable insights into between health.

Language: Английский

Citations

2