Risk factors, prevention and screening of colorectal cancer: A rising problem DOI
В. В. Цуканов, A. V. Vasyutin, Yu.L. Tonkikh

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 31(5)

Published: Dec. 30, 2024

Colorectal cancer (CRC) is the third most commonly diagnosed and second leading cause of death worldwide. The risk factors for CRC include male gender, age over 50, family history, obesity, tobacco smoking, alcohol consumption, unhealthy diet. screening methods vary considerably between countries depend on incidence, economic resources healthcare structure. Important aspects adherence, which can significantly across ethnic socioeconomic groups. Basic concepts pre-stratification patients by identifying then using fecal immunochemical test or guaiac-based occult blood and/or colonoscopy radiologic imaging techniques. Technological capabilities are rapidly evolving stool DNA test, liquid biopsy, virtual colonography, use artificial intelligence. A prevention strategy should be comprehensive active patient education along with targeted implementation screening.

Language: Английский

Recent advances in nano-enhanced biosensors: Innovations in design, applications in healthcare, environmental monitoring, and food safety, and emerging research challenges DOI Creative Commons
Mohamed Hemdan,

Khaled Abuelhaded,

A. A. Shaker

et al.

Sensing and Bio-Sensing Research, Journal Year: 2025, Volume and Issue: unknown, P. 100783 - 100783

Published: April 1, 2025

Language: Английский

Citations

0
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies DOI Creative Commons
Zhongmin Qiu, Yifan Cheng,

Haiyan Liu

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 16, 2025

Abstract Background This study aims to screen, validate novel biomarkers and develop a user-friendly online tool for the detection of colorectal cancer (CRC). Methods Multi-omics approach, comprising proteomic analysis single-cell transcriptomic analysis, was utilized discover candidate tumor-associated antigens (TAAs). The presence autoantibodies (TAAbs) in serum subsequently assessed using enzyme-linked immunosorbent assays (ELISA) 300 CRC patients healthy controls. Ten machine learning algorithms were diagnostic models, with optimal one selected integrated into an R Shiny-based GUI enhance usability accessibility. Results We identified twelve potential TAAs: HMGA1, NPM1, EIF1AX, CKS1B, HSP90AB1, ACTG1, S100A11, maspin, ANXA3, eEF2, P4HB, HKDC1. ELISA results showed that five TAAbs including anti-CKS1B, anti-S100A11, anti-maspin, anti-ANXA3, anti-eEF2 during evaluation phase (all P < 0.05). Random Forest model yielded AUC 0.82 (95% CI: 0.78–0.88) on training set 0.75 0.68–0.82) test set, demonstrating robustness results. Web-based implementations tools are publicly accessible via weblink https://qzan.shinyapps.io/CRCPred/ . Conclusions A biomarker panel can server as complementary CEA CA19-9 detection.

Language: Английский

Citations

0
Microbiota as diagnostic biomarkers: advancing early cancer detection and personalized therapeutic approaches through microbiome profiling DOI Creative Commons
Majid Eslami, Ramtin Naderian, Aisa Bahar

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

The important function of microbiota as therapeutic modulators and diagnostic biomarkers in cancer has been shown by recent developments microbiome research. intricate interplay between the gut development cancer, especially colorectal breast cancers, emphasizes how microbial profiling may be used for precision treatment early diagnosis. Important signatures, including Bacteroides fragilis Fusobacterium nucleatum , have linked to progression providing information on processes behind carcinogenesis. Additionally, influence effectiveness treatments such immunotherapy chemotherapy highlights its dual improving outcomes reducing side effects. To optimize results, strategies dietary changes fecal transplantation (FMT) are being investigated. Despite these developments, there still issues, individual variations composition, a lack standardized procedures, requirement reliable biomarkers. Integrating microbiome-based diagnostics with conventional approaches, liquid biopsies machine learning algorithms, could revolutionize detection management. This review provides an overview current understanding host–microbe immunological axis discusses emerging centered modulation support human health. Further research is essential overcome existing challenges fully realize promise microbiota-driven innovations oncology.

Language: Английский

Citations

0
Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer DOI Open Access

Janine Soares,

Mariana Eiras, Dylan Ferreira

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3722 - 3722

Published: March 27, 2024

Colorectal cancer (CRC) screening relies primarily on stool analysis to identify occult blood. However, its sensitivity for detecting precancerous lesions is limited, requiring the development of new tools improve CRC screening. Carcinogenesis involves significant alterations in mucosal epithelium glycocalyx that decisively contribute disease progression. Building this knowledge, we examined patient series comprehending premalignant lesions, colorectal tumors, and healthy controls T-antigen—a short-chain O-glycosylation proteins considered a surrogate marker malignancy multiple solid cancers. We found T-antigen secretions dysplastic as well cancer. In CRC, expression was associated with presence distant metastases. parallel, analyzed broad number stools from individuals who underwent colonoscopy, which showed high T expressions high-grade dysplasia carcinomas. Employing mass spectrometry-based lectin-affinity enrichment, identified total 262 proteins, 67% potentially exhibited altered glycosylation patterns advanced pre-cancerous lesions. Also, (glyco)proteome enriched protein species involved key biological processes linked humoral innate immune responses. This study offers thorough glycoproteome, laying groundwork harnessing non-invasive detection.

Language: Английский

Citations

2
An in-silico study on the mechanical behavior of colorectal cancer cell lines in the micropipette aspiration process DOI

Ibrahim Ghoytasi,

Omid Bavi, Mohammad R. K. Mofrad

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 178, P. 108744 - 108744

Published: June 17, 2024

Language: Английский

Citations

2
Oxidative Stress Assessment in Colorectal Cancer Patients DOI Creative Commons
Vyan A. Qadir, Kamaran Abdoulrahman

ARO-The Scientific Journal of Koya University, Journal Year: 2024, Volume and Issue: 12(1), P. 115 - 123

Published: May 10, 2024

Colorectal cancer (CRC), a global health challenge, exhibits rising incidence in low-income nations due to lifestyle changes. Oxidative stress, indicated by reactive oxygen species imbalance and Malondialdehyde (MDA), is linked CRC. This study investigates oxidative stress markers, antioxidant enzymes, genetic cellular regulation Vitamin E CRC patients Erbil. Ninety 30 healthy controls provided blood samples, processed stored at –20°C. Enzyme-linked immunosorbent assay kits quantified E. markers showed significant differences, with elevated MDA 8-hydroxy-2’-deoxyguanosine levels patients. Nitrotyrosine exhibited lower expression Antioxidant enzymes glutathione peroxidase superoxide dismutase were enhanced patients, while (GSH), reductase catalase significantly The marker KRAS substantial decrease (<0.0001) but both adenomatous polyposis coli (APC) antigen (CCA) higher. Serum vitamin (71.78 ± 6.368) compared (142.3 4.828, p < 0.0001). Elevated altered enzymatic activity, of KRAS, higher APC CCA the patient group. Furthermore, reduced observed group, highlighting potential challenges defense.

Language: Английский

Citations

1
Exploring Anticancer Potential of Lactobacillus Strains: Insights into Cytotoxicity and Apoptotic Mechanisms on HCT 115 Cancer Cells DOI Creative Commons

Luolin Wang,

Zhenglei Xu, Aarti Bains

et al.

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 285 - 295

Published: Oct. 1, 2024

This study aims to systematically assess the anticancer potential of distinct

Language: Английский

Citations

1
Efficacy and Safety of Fluorescence-Guided Surgery Compared to Conventional Surgery in the Management of Colorectal Cancer: A Systematic Review and Meta-Analysis DOI Open Access
Michael G. Fadel, Elham Zonoobi, María Rita Rodríguez‐Luna

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3377 - 3377

Published: Oct. 2, 2024

Background: The use of fluorescence agents and imaging systems is a promising adjunct in the surgical management colorectal cancer. This systematic review meta-analysis aimed to assess safety efficacy fluorescence-guided surgery cancer, with comparison conventional (non-fluorescence-guided) surgery. Methods: A literature search MEDLINE, Embase, Emcare, CINAHL databases was performed for studies that reported data on outcomes surgery, or without group undergoing cancer between January 2000 2024. using random-effect models, between-study heterogeneity assessed. Results: 35 3217 patients were included: 26 (964 patients) 9 (2253 versus weighted mean detection rate 71% (95% CI 0.55–0.85), no significant difference lymph node yield ratio (WMD −0.04; 95% −0.10–0.02; p = 0.201) groups. There significantly lower blood loss −4.38; −7.05–−1.70; 0.001) complication −0.07–0.00; 0.027) group, potentially anastomotic leak −0.05; −0.10–0.01; 0.092). Conclusions: Fluorescence-guided safe effective approach reducing complications. Further randomised controlled trials are required comparing determine its prognostic benefit where it should precisely fit within pathway

Language: Английский

Citations

1
LncRNA MALAT1 as diagnostic and prognostic biomarker in colorectal cancers: A systematic review and meta-analysis DOI Creative Commons
Mahdi Masrour, Shaghayegh Khanmohammadi,

Amirhossein Habibzadeh

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0308009 - e0308009

Published: Oct. 29, 2024

Objective This study investigated the relationship between long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) expression and colorectal cancer (CRC) using a thorough systematic review meta-analysis. Methods Under PRISMA guidelines, was conducted on studies published from databases’ inception to September 18, 2023. Prognostic value diagnostic accuracy were explored. Additionally, association levels of MALAT1 pathological features investigated. The statistical analysis performed “meta” package R. Results Among parameters examined, based three involving 51 cases metastatic CRC 135 non-metastatic CRC, statistically significant correlation found level distant metastasis, with an OR 16.0118 (95% CI: 4.5618–56.2015). Three 378 reported overall survival had pooled HR 2.3854 1.3272–4.2875). 436 disease-free 2.4772 1.3774–4.4549). All prognosis utilized tumor tissue samples as specimens assess MALAT1. Case-to-control 126 controls AUC 0.6173 0.5436–0.6909), sensitivity 0.675 0.324–0.900), specificity 0.771 0.685–0.839). Conclusions in is highly correlated metastasis has impact prognosis. could also be employed biomarker. More prospective should potential early stages CRC.

Language: Английский

Citations

1
Global Trend of Ovarian Cancer Among old age women: an Analysis by Socio-Demographic Index and Geographic Regions DOI
Leila Allahqoli, Afrooz Mazidimoradi, Fatemeh Rezaei

et al.

Indian Journal of Gynecologic Oncology, Journal Year: 2024, Volume and Issue: 22(4)

Published: Nov. 1, 2024

Language: Английский

Citations

1