Determination of methotrexate using carbon paste electrode modified with ionic liquid/Ni-Co layered double hydroxide nanosheets as a voltammetric sensor

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Background and purpose: Methotrexate (MTX) is a widely used anti-cancer drug, but its overuse can lead to significant side effects. Therefore, it very vital design simple sensitive analytical methods for determi­na­tion. Experimental approach: In this work, an electrochemical sensor was prepared based on ionic liquid (IL)/Ni-Co layered double hydroxide nanosheets (Ni-Co-LDH)-modified carbon paste electrode IL/Ni-Co-LDH/CPE. Cyclic voltammetry, differential pulse chronoamperometry were applied evaluate the performance of designed MTX determination. Key results: The IL/Ni-Co-LDH/CPE exhibits linear relationship between peak current voltammetry concentrations in dynamic range 0.02 140.0 µM, with detection limit 0.006 µM. exhibited relative standard deviation values 1.7 3.7 % recovery tests real samples, indicating precision method. Conclusion: cost-effective good could be valuable therapeutic drug monitoring clinical diagnostics.

Language: Английский

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Novel and simple electrochemical sensing platform based on polypyrrole nanotubes/ZIF-67 nanocomposite/screen printed graphite electrode for sensitive determination of metronidazole

Electrochemistry Communications, Journal Year: 2024, Volume and Issue: 169, P. 107824 - 107824

Published: Oct. 12, 2024

Language: Английский

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Electrochemical Determination of Doxorubicin in the Presence of Dacarbazine Using MWCNTs/ZnO Nanocomposite Modified Disposable Screen-Printed Electrode

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 60 - 60

Published: Jan. 17, 2025

In the current work, MWCNTs/ZnO nanocomposite was successfully synthesized using simple method. Then, FE-SEM, XRD, and EDX techniques were applied for morphological structural characterization. Afterward, a sensitive voltammetric sensor based on modification of screen-printed carbon electrode (SPCE) developed determination doxorubicin in presence dacarbazine. To evaluate electrochemical response MWCNTs/ZnO/SPCE towards doxorubicin, cyclic voltammetry (CV) applied. The showed significant synergistic effect redox reaction doxorubicin. Also, demonstrated an enhanced sensing platform quantification obtaining detection limit (LOD) 0.002 µM sensitivity 0.0897 µA/µM, as determined by differential pulse (DPV) within linear range from 0.007 to 150.0 µM. nanocomposite-modified SPCE high activities oxidation dacarbazine with peak-potential separation 345 mV, which is sufficient presented reproducible stable responses determine Finally, successful performance real samples, recovery 97.1% 104.0% relative standard deviation (RSD) 1.8% 3.5%.

Language: Английский

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MIL-101 (Fe)-NH2 meta-organic framework/graphene oxide nanocomposite modified screen-printed carbon electrode for electrochemical sensing of 2,4-dichlorophenol in water samples

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42285 - e42285

Published: Jan. 1, 2025

Language: Английский

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Developments in the Fabrication of Nanomaterial-Based Voltammetric Sensors

Published: Jan. 1, 2025

Language: Английский

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Application of two-dimensional zeolitic imidazolate framework-L (Co)/multi-walled carbon nanotube nanocomposite modified electrode as a sensitive voltammetric sensor for determination of cannabidiol

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112892 - 112892

Published: July 26, 2024

Language: Английский

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The development of a disposable voltammetric sensor based on two-dimensional leaf-like ZIF-L (Zn) modified screen-printed graphite electrode for the simultaneous analysis of uric acid, dopamine and theophylline

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113158 - 113158

Published: Sept. 1, 2024

Language: Английский

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Simultaneous Voltammetric Determination of Morphine and Tramadol Using Zirconium-Based Metal Organic Framework Modified Electrode

Topics in Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Language: Английский

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Facile Synthesis of Reduced Graphene Oxide/Mn₃O₄ Nanocomposite as a Platform for the Voltammetric Determination of Tramadol

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(30)

Published: Aug. 7, 2024

Abstract We describe a simple hydrothermal method for preparing nanocomposite of reduced graphene oxide/Mn 3 O 4 (rGO/Mn ), and its use in electrochemically detecting tramadol (TRA). The sensor was constructed by using glassy carbon electrode modified with rGO/Mn /GCE) as an electro‐catalyst. electrochemical properties TRA at /GCE were studied cyclic voltammetry (CV), chronoamperometry, differential pulse (DPV) phosphate buffer solution (PBS) pH 8.0. oxidation peak currents on increased compared to the bare GCE. This enhancement attributed high surface area excellent electron transfer performance electrode. Under optimal conditions, exhibited linear increase concentration within range 0.5 700.0 μM, detection limit (LOD) 0.16 μM achieved. study has shown that can effectively be used analyze real specimens.

Language: Английский

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MnWO4/reduced graphene oxide-based electrochemical sensing platform for simultaneous detection of catechol and resorcinol

Diamond and Related Materials, Journal Year: 2024, Volume and Issue: 149, P. 111579 - 111579

Published: Sept. 6, 2024

Language: Английский

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