Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Sci, Journal Year: 2025, Volume and Issue: 7(1), P. 27 - 27
Published: March 4, 2025
From its inception, cell culture has been a great scientific tool for researchers in many diverse fields. The advancement from monolayer 2D cultures into three-dimensional cellular systems enabled better experimental tool, as the 3D mimics vivo environments more closely. Cells are aggregated clusters, allowing cell-to-cell interactions, migration, and differences nutrient oxygen availability. Spheroids organoids most commonly used have proven themselves models large number of analytical purposes. simplicity spheroid production is often good starting point. Because complex, they can provide complete data, but be difficult to grow maintain. With increasing concern about applicability data obtained animal studies questions regarding welfare, these replace proportion accurate rapid results. In this overview, aimed at someone looking an introductory summary requirements possibilities different approaches, we give basic information on various uses spheroids fields science. Assays based adapted range applications, their use will continue grow.
Language: Английский
Citations
0
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117472 - 117472
Published: April 1, 2025
Language: Английский
Citations
0
Biosensors, Journal Year: 2024, Volume and Issue: 14(9), P. 429 - 429
Published: Sept. 5, 2024
Recent advances in three-dimensional (3D) culturing and nanotechnology offer promising pathways to overcome the limitations of drug screening, particularly for tumors like neuroblastoma. In this study, we develop a high-throughput microfluidic chip that integrates concentration gradient generator (CGG) with 3D co-culture system, constructing vascularized microenvironment by co-culturing neuroblastoma (SY5Y cell line) human brain microvascular endothelial cells (HBMVECs) within decellularized extracellular matrix (dECM) hydrogels. The automated platform enhances simulation tumor allows precise control concentrations nanomedicines, which is crucial evaluating therapeutic efficacy. findings demonstrate can significantly accelerate discovery. It efficiently screens analyzes interactions biologically relevant setting, potentially revolutionizing screening process.
Language: Английский
Citations
0
Biosensors, Journal Year: 2024, Volume and Issue: 14(10), P. 469 - 469
Published: Sept. 30, 2024
Microfluidics are crucial for managing small-volume analytical solutions various applications, such as disease diagnostics, drug efficacy testing, chemical analysis, and water quality monitoring. The precise control of flow devices can generate diverse patterns using pneumatic with solenoid valves a microcontroller. This system enables the active modulation pressure through Arduino programming connected to source. Additionally, incorporation valve sets allows multichannel control, enabling simultaneous creation manipulation microflows at low cost. proposed microfluidic controller facilitates accurate regulation, especially periodic beneficial droplet generation continuous production microdroplets different sizes. Overall, we expect drive innovative advancements in technology medicine owing its engineering precision versatility.
Language: Английский
Citations
0
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(21), P. 3828 - 3847
Published: Oct. 22, 2024
The brain is an incredibly complex structure that consists of millions neural networks. In developmental and cellular neuroscience, probing the highly dynamics remains a challenge. Furthermore, deciphering how several cues can influence neuronal growth its interactions with different cell types (such as astrocytes microglia) also formidable task. Traditional
Language: Английский
Citations
0
Coatings, Journal Year: 2024, Volume and Issue: 14(12), P. 1483 - 1483
Published: Nov. 24, 2024
Advancements in wearable technology and lab-on-chip devices necessitate improved integrated microflow pumps with lower driving voltages. This study examines a piezoelectric pump using flexible β-phase copolymer poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) film. Six samples (S1–S6) were fabricated subjected to three-step annealing process optimize their properties. Characterization was conducted via atomic force microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, impedance analysis, polarization hysteresis loop measurements. The results show that at approximately 135 degrees Celsius produces structure uniform “rice grain”-like crystallites. A microfluidic nozzle/diffuser structure, S4 film as the drive layer, designed manufactured. Diaphragm deformation performance assessed, showing maximum water flow rate of 25 µL/min 60 Hz peak-to-peak voltage (Vpp) V. could be precisely controlled within 0–25 by adjusting Vpp frequency. effectively reduced pump, it has significant implications for smart devices.
Language: Английский
Citations
0
Advanced Sensor and Energy Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100131 - 100131
Published: Dec. 1, 2024
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0