Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules DOI Creative Commons

Regina Kuanaeva,

Alexander N. Vaneev,

Petr V. Gorelkin

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 627 - 627

Published: Dec. 19, 2024

Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, multifunctionality. The features significantly expanded interest their applications biomolecular detection, imaging, molecular diagnostics real samples. Moreover, ease manufacturing nanopipettes, coupled with compatibility fluorescence electrochemical methods, makes them ideal portable point-of-care diagnostic devices. This review summarized latest progress nanopipette-based nanopore technology biomarkers, DNA, RNA, proteins, peptides, particular β-amyloid or α-synuclein, emphasizing impact on diagnostics. By addressing key challenges expanding diverse areas, nanopipettes are poised to play transformative role future personalized medicine.

Language: Английский

Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment DOI Creative Commons
Baoming Liu,

A. Wallace Hayes

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2401 - 2401

Published: Oct. 20, 2024

Engineered nanomaterials (ENMs) have a broad array of applications in agriculture, engineering, manufacturing, and medicine. Decades toxicology research demonstrated that ENMs can cause genotoxic effects on bacteria, mammalian cells, animals. Some metallic (MENMs), e.g., metal or oxide nanoparticles TiO

Language: Английский

Citations

4
Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules DOI Creative Commons

Regina Kuanaeva,

Alexander N. Vaneev,

Petr V. Gorelkin

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 627 - 627

Published: Dec. 19, 2024

Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, multifunctionality. The features significantly expanded interest their applications biomolecular detection, imaging, molecular diagnostics real samples. Moreover, ease manufacturing nanopipettes, coupled with compatibility fluorescence electrochemical methods, makes them ideal portable point-of-care diagnostic devices. This review summarized latest progress nanopipette-based nanopore technology biomarkers, DNA, RNA, proteins, peptides, particular β-amyloid or α-synuclein, emphasizing impact on diagnostics. By addressing key challenges expanding diverse areas, nanopipettes are poised to play transformative role future personalized medicine.

Language: Английский

Citations

0