The Effect of MoS2 and Si3N4 in Surface Plasmon Resonance Biosensors for HIV DNA Hybridization Detection: A Numerical Study DOI Creative Commons
Talía Tene, Diana Coello-Fiallos,

María de Lourdes Palacios Robalino

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(3), P. 295 - 295

Published: Feb. 28, 2025

This study presents a numerical investigation of surface plasmon resonance (SPR) biosensors incorporating silicon nitride (Si3N4) and molybdenum disulfide (MoS2) for HIV DNA hybridization detection. By optimizing the thickness Ag Si3N4 number MoS2 layers, two configurations, Sys2 (Ag-Si3N4) Sys3 (Ag-Si3N4-MoS2), were selected comparative analysis. Performance metrics, including angle shift, sensitivity, detection accuracy, quality factor, demonstrated that achieved highest sensitivity 210.9°/RIU an enhanced figure merit (86.98 RIU−1), surpassing state-of-the-art SPR sensors. Although exhibited lower 158.1°/RIU due to MoS2-induced optical losses, it provided limit detection, suggesting trade-off between spectral broadening. Compared previous biosensors, proposed configurations achieve superior while maintaining stability selectivity, positioning them as promising candidates next-generation nucleic acid platforms.

Language: Английский

WS2/Si3N4-Based Biosensor for Low-Concentration Coronavirus Detection DOI Creative Commons
Talía Tene, Fabian Arias Arias, Karina I. Paredes-Páliz

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(2), P. 128 - 128

Published: Jan. 23, 2025

This study presents the optimization of two SPR biosensors, Sys3 and Sys5, for SARS-CoV-2 detection at concentrations 0.01-100 nM. Sys3, with a 55 nm silver layer, 13 silicon nitride 10 ssDNA achieved figure merit (FoM) 571.24 RIU-1, signal-to-noise ratio (SNR) 0.12, accuracy (DA) 48.93 × 10-2. incorporating 50 1.6 tungsten disulfide layer (L = 2), demonstrated higher sensitivity 305.33 °/RIU lower limit (LoD) 1.65 10-5. outshined in precision low attenuation (<1%), while Sys5 provided enhanced limits, crucial early-stage viral detection. These configurations align refractive index ranges clinical samples, showcasing their diagnostic potential. Future work will focus on experimental validation integration into point-of-care platforms.

Language: Английский

Citations

2
The Effect of MoS2 and Si3N4 in Surface Plasmon Resonance Biosensors for HIV DNA Hybridization Detection: A Numerical Study DOI Creative Commons
Talía Tene, Diana Coello-Fiallos,

María de Lourdes Palacios Robalino

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(3), P. 295 - 295

Published: Feb. 28, 2025

This study presents a numerical investigation of surface plasmon resonance (SPR) biosensors incorporating silicon nitride (Si3N4) and molybdenum disulfide (MoS2) for HIV DNA hybridization detection. By optimizing the thickness Ag Si3N4 number MoS2 layers, two configurations, Sys2 (Ag-Si3N4) Sys3 (Ag-Si3N4-MoS2), were selected comparative analysis. Performance metrics, including angle shift, sensitivity, detection accuracy, quality factor, demonstrated that achieved highest sensitivity 210.9°/RIU an enhanced figure merit (86.98 RIU−1), surpassing state-of-the-art SPR sensors. Although exhibited lower 158.1°/RIU due to MoS2-induced optical losses, it provided limit detection, suggesting trade-off between spectral broadening. Compared previous biosensors, proposed configurations achieve superior while maintaining stability selectivity, positioning them as promising candidates next-generation nucleic acid platforms.

Language: Английский

Citations

2