Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications DOI Creative Commons
Nadiah Alyamni, Jandro L. Abot, Alexander G. Zestos

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 7, 2025

Carbon microelectrodes (CMEs) have emerged as pivotal tools in the field of neurochemical sensing, enabling precise, real-time monitoring neurotransmitters both research and clinical contexts. The current review explores design, fabrication, application CMEs, emphasizing recent advancements material science electrochemical techniques that enhance their sensitivity, selectivity, biocompatibility. Innovations such incorporation nanomaterials, including graphene carbon nanotubes, adoption advanced fabrication methods like three-dimensional (3D) printing chemical vapor deposition, are discussed detail. These developments led to significant improvements electrode performance, reduction biofouling interferants, while detection low concentrations neurochemicals complex biological systems. This further highlights potential CMEs address challenges diagnosing neurological disorders Parkinson’s Disease depression. By integrating surface modifications, polymer coatings, method development strategies, demonstrate high durability, reduced fouling, enhanced specificity. Despite these advancements, remain related long-term vivo stability, batch reproducibility, thus necessitating optimization. transformative therapeutic applications, providing a comprehensive overview state future directions. addressing existing limitations leveraging emerging technologies, sensing contribute breakthroughs neuroscience biomedical science.

Language: Английский

Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications DOI Creative Commons
Nadiah Alyamni, Jandro L. Abot, Alexander G. Zestos

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 7, 2025

Carbon microelectrodes (CMEs) have emerged as pivotal tools in the field of neurochemical sensing, enabling precise, real-time monitoring neurotransmitters both research and clinical contexts. The current review explores design, fabrication, application CMEs, emphasizing recent advancements material science electrochemical techniques that enhance their sensitivity, selectivity, biocompatibility. Innovations such incorporation nanomaterials, including graphene carbon nanotubes, adoption advanced fabrication methods like three-dimensional (3D) printing chemical vapor deposition, are discussed detail. These developments led to significant improvements electrode performance, reduction biofouling interferants, while detection low concentrations neurochemicals complex biological systems. This further highlights potential CMEs address challenges diagnosing neurological disorders Parkinson’s Disease depression. By integrating surface modifications, polymer coatings, method development strategies, demonstrate high durability, reduced fouling, enhanced specificity. Despite these advancements, remain related long-term vivo stability, batch reproducibility, thus necessitating optimization. transformative therapeutic applications, providing a comprehensive overview state future directions. addressing existing limitations leveraging emerging technologies, sensing contribute breakthroughs neuroscience biomedical science.

Language: Английский

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