Human Brain Mapping,
Journal Year:
2023,
Volume and Issue:
45(1)
Published: Dec. 11, 2023
Abstract
Background
Executive
function
enhancement
is
considered
necessary
for
improving
the
quality
of
life
patients
with
neurological
or
psychiatric
disorders,
such
as
attention‐deficit/hyperactivity
disorder,
obsessive‐compulsive
disorder
and
Alzheimer's
disease.
Transcranial
electrical
stimulation
(tES)
has
been
shown
to
have
some
beneficial
effects
on
executive
functioning,
but
quantification
these
improvements
remains
controversial.
We
aimed
explore
potential
functioning
induced
by
use
transcranial
alternating
current
(tACS)/transcranial
direct
(tDCS)
right
inferior
frontal
gyrus
(IFG)
accompanying
brain
variations
in
resting
state.
Methods
recruited
229
healthy
adults
participate
Experiments
1
(105
participants)
2
(124
participants).
The
participants
each
experiment
were
randomly
divided
into
tACS,
tDCS,
sham
groups.
completed
cognitive
tasks
assess
behavior
related
three
core
components
functions.
Functional
near‐infrared
spectroscopy
(fNIRS)
was
used
monitor
hemodynamic
changes
crucial
cortical
regions
Results
Inhibition
flexibility
(excluding
working
memory)
significantly
increased
after
tACS/tDCS,
there
no
significant
behavioral
differences
between
tACS
tDCS
fNIRS
revealed
that
decreases
functional
connectivity
(increased
neural
efficiency)
relevant
cortices.
Conclusions
Enhancement
observed
tES,
tACS/tDCS
may
need
be
precisely
evaluated
via
imaging
indicators
at
rest.
better
benefits
than
during
phase.
These
findings
might
provide
new
insights
selecting
intervention
methods
future
studies
evaluating
clinical
efficacy
tES.
Frontiers in Human Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: Feb. 19, 2025
This
study
investigates
the
effects
of
temporal
interference
stimulation
(TI)
with
different
envelope
frequencies
on
cortical
excitability
primary
motor
cortex
(M1).
In
this
randomized,
double-blind,
crossover
study,
26
participants
completed
four
separate
visits.
During
these
visits,
they
received
20
min
three
types
TI
(10,
20,
and
40
Hz
frequency)
sham
applied
over
M1
in
a
randomized
order.
Transcranial
magnetic
(TMS)
was
employed
to
assess
motor-evoked
potentials
(MEP)
resting
threshold
(RMT)
left
(ipsilateral
area)
right
(contralateral
before,
immediately
after,
30
60
after
stimulation.
The
blinding
efficacy
excellent,
no
severe
side
were
reported.
varying
affected
MEP
differently;
enhanced
ipsilateral
after-effects
appearing
at
min,
significant
differences
observed
between
10
or
groups.
However,
changes
RMT
under
any
conditions.
increased
M1,
highlighting
that
frequency
is
an
important
factor
modulatory
effect
TI.
Psicothema,
Journal Year:
2025,
Volume and Issue:
37(2), P. 1 - 11
Published: Jan. 1, 2025
Age-related
cognitive
decline
is
rising
due
to
longer
life
expectancy,
necessitating
new
treatments
as
current
drugs
are
ineffective
and
costly.
Transcranial
alternating
stimulation
at
the
theta
frequency
(theta-tACS)
has
shown
promise
in
enhancing
function
both
young
elderly
adults,
but
its
effectiveness
those
with
not
well-studied.
This
study
involved
27
participants
subjective
(SCD),
mild
impairment
(MCI),
dementia,
who
underwent
multiple
sessions
combining
computerized
training
theta-tACS
assess
efficacy.
Participants
were
randomly
assigned
either
a
real-tACS
or
sham-tACS
group.
Before
after
treatment,
they
completed
several
tasks,
their
behavioral
EEG
data
collected.
Only
group
improved
oddball
task
exhibited
increased
event-related
amplitude
range.
These
findings
suggest
that
can
improve
performance
individuals
psychophysiological
levels,
supporting
potential
for
alleviating
populations.
Human Brain Mapping,
Journal Year:
2023,
Volume and Issue:
45(1)
Published: Dec. 11, 2023
Abstract
Background
Executive
function
enhancement
is
considered
necessary
for
improving
the
quality
of
life
patients
with
neurological
or
psychiatric
disorders,
such
as
attention‐deficit/hyperactivity
disorder,
obsessive‐compulsive
disorder
and
Alzheimer's
disease.
Transcranial
electrical
stimulation
(tES)
has
been
shown
to
have
some
beneficial
effects
on
executive
functioning,
but
quantification
these
improvements
remains
controversial.
We
aimed
explore
potential
functioning
induced
by
use
transcranial
alternating
current
(tACS)/transcranial
direct
(tDCS)
right
inferior
frontal
gyrus
(IFG)
accompanying
brain
variations
in
resting
state.
Methods
recruited
229
healthy
adults
participate
Experiments
1
(105
participants)
2
(124
participants).
The
participants
each
experiment
were
randomly
divided
into
tACS,
tDCS,
sham
groups.
completed
cognitive
tasks
assess
behavior
related
three
core
components
functions.
Functional
near‐infrared
spectroscopy
(fNIRS)
was
used
monitor
hemodynamic
changes
crucial
cortical
regions
Results
Inhibition
flexibility
(excluding
working
memory)
significantly
increased
after
tACS/tDCS,
there
no
significant
behavioral
differences
between
tACS
tDCS
fNIRS
revealed
that
decreases
functional
connectivity
(increased
neural
efficiency)
relevant
cortices.
Conclusions
Enhancement
observed
tES,
tACS/tDCS
may
need
be
precisely
evaluated
via
imaging
indicators
at
rest.
better
benefits
than
during
phase.
These
findings
might
provide
new
insights
selecting
intervention
methods
future
studies
evaluating
clinical
efficacy
tES.
