Insights into attention and memory difficulties in post-COVID syndrome using standardized neuropsychological tests and experimental cognitive tasks DOI Creative Commons
Sandra Arbula, Elisabetta Pisanu,

Giulia Bellavita

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 22, 2024

Abstract The COVID-19 pandemic has given rise to post-acute cognitive symptoms, often described as ‘brain fog’. To comprehensively grasp the extent of these issues, we conducted a study integrating traditional neuropsychological assessments with experimental tasks targeting attention control, working memory, and long-term three domains most commonly associated We enrolled 33 post-COVID patients, all self-reporting difficulties, matched control group (N = 27) for psychological assessments. Our findings revealed significant deficits in patients across both measurements tasks, evidencing reduced performance involving interference resolution selective sustained attention. Mild executive function naming impairments also emerged from assessment. Notably, 61% reported prospective memory failures daily life, aligning our recruitment focus. Furthermore, patient showed alterations psycho-affective domain, indicating complex interplay between factors, which could point non-cognitive determinant subjectively experienced changes following COVID-19. In summary, offers valuable insights into challenges faced by individuals recovering COVID-19, stressing importance comprehensive evaluations supporting individuals.

Language: Английский

Neuropsychological deficits in patients with persistent COVID-19 symptoms: a systematic review and meta-analysis DOI Creative Commons

Saioa Sobrino-Relaño,

Yolanda Balboa-Bandeira, Javier Peña

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 26, 2023

Long-term persistent symptoms of COVID-19 affect 30-80% patients who have recovered from the disease and may continue for a long time after has been overcome. The duration these over might consequences that different aspects health, such as cognitive abilities. main objective this systematic review meta-analysis was to objectify deficits acute phase infection summarize existing evidence. Additionally, we aimed provide comprehensive overview further understand address disease. Our protocol registered in PROSPERO (CRD42021260286). Systematic research conducted Web Science, MEDLINE, PubMed, PsycINFO, Scopus, Google Scholar databases January 2020 September 2021. Twenty-five studies were included, six which analyzed meta-analysis, consisted 175 had 275 healthy individuals. Analyses performance post-COVID-19 volunteers compared using random-effects model. results showed an overall medium-high effect size (g = -.68, p .02) with 95% CI (-1.05 -.31), significantly moderate level heterogeneity among (Z 3.58, < .001; I

Language: Английский

Citations

30
Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants DOI Creative Commons
Simone Beretta,

Viviana Cristillo,

Giorgia Camera

et al.

Neurology, Journal Year: 2023, Volume and Issue: 101(9)

Published: July 6, 2023

Background and Objective

A variety of neurological disorders has been reported as presentations or complications COVID-19 infection. The objective this study was to determine their incidence dynamics long-term functional outcome.

Methods

Neuro-COVID Italy a multicentre, observational, cohort with ambispective recruitment prospective follow-up. Consecutive hospitalized patients presenting new associated infection (neuro-COVID), independently from respiratory severity, were systematically screened actively recruited by neurology specialists in 38 centers the Republic San Marino. primary outcomes neuro-COVID cases during first 70 weeks pandemic (March 2020 June 2021) outcome at 6 months, categorized full recovery, mild symptoms, disabling symptoms death.

Results

Among 52759 COVID patients, 1865 2881 (neuro-COVID) recruited. Incidence significantly declined over time, comparing three waves (8.4%, 95% CI [7.9, 8.9]; 5.0%, [4.7, 5.3]; 3.3%, [3.0, 3.6], respectively; p = 0.027). most frequent acute encephalopathy (25.2%), hyposmia-hypogeusia (20.2%), ischemic stroke (18.4%) cognitive impairment (13.7%). onset more common prodromic phase (44.3%) illness (40.9%), except for whose prevailed recovery (48.4%). good achieved majority (64.6%) follow-up (median 6.7 months) proportion increased throughout period (r 0.29, [0.05, 0.50]; 0.019). Mild residual frequently (28.1%), while only survivors (47.6%).

Discussion

COVID-associated neurologic decreased pre-vaccination pandemic. Long-term favourable disorders, although commonly lasted months after

Language: Английский

Citations

28
Cognitive domains affected post‐COVID‐19; a systematic review and meta‐analysis DOI Creative Commons
Jack B. Fanshawe, Brendan Sargent, James Badenoch

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Abstract Background and purpose This review aims to characterize the pattern of post‐COVID‐19 cognitive impairment, allowing better prediction impact on daily function inform clinical management rehabilitation. Methods A systematic meta‐analysis neurocognitive sequelae following COVID‐19 was conducted, PRISMA‐S guidelines. Studies were included if they reported domain‐specific assessment in patients with at >4 weeks post‐infection. deemed high‐quality had >40 participants, utilized healthy controls, low attrition rates mitigated for confounders. Results Five seven primary Diagnostic Statistical Manual Mental Disorders (DSM‐5) domains assessed by enough studies facilitate meta‐analysis. Medium effect sizes indicating impairment versus controls seen across executive (standardised mean difference (SMD) −0.45), learning memory (SMD −0.55), complex attention −0.54) language −0.54), perceptual motor appearing be impacted a greater degree −0.70). narrative synthesis 56 low‐quality also suggested no obvious impairment. Conclusions found moderate impairments multiple cognition post‐COVID‐19, specific pattern. The literature significantly heterogeneous, wide variety tasks, small sample disparate initial disease severities limiting interpretability. finding consistent range tasks suggests broad, as opposed domain‐specific, brain dysfunction. Future should utilize harmonized test battery inter‐study comparisons, whilst accounting interactions between COVID‐19, neurological mental health, interplay which might explain

Language: Английский

Citations

10
Neurocognitive Impairment in Long COVID: A Systematic Review DOI Creative Commons

Ευγενία Παναγέα,

Lambros Messinis,

Maria Christina Petri

et al.

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Objective Although Coronavirus disease 2019 (COVID-19) is primarily a respiratory infectious disease, it has also been associated with wide range of other clinical manifestations. It widely accepted in the scientific community that many patients after recovery continue to experience COVID-19-related symptoms, including cognitive impairment. The aim this systematic review was investigate profile long-COVID syndrome. Methods A search empirical studies conducted through PubMed/Medline and Scopus electronic databases. Cross-sectional longitudinal published between 2020 2023 were included. Results Of 516 assessed for eligibility, 36 met inclusion criteria. All included support presence persistent changes COVID-19 disease. Executive function, memory, attention, processing speed appear be domains are predominantly syndrome, whereas language an area not sufficiently investigated. Conclusions In review, high frequency impairment evident. If we consider functioning affects our ability live independently key determinant quality life, imperative precisely define those factors may induce survivors, ultimate goal early diagnosis and, consequently, development targeted rehabilitation interventions address them.

Language: Английский

Citations

10
Insights into attention and memory difficulties in post-COVID syndrome using standardized neuropsychological tests and experimental cognitive tasks DOI Creative Commons
Sandra Arbula, Elisabetta Pisanu,

Giulia Bellavita

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 22, 2024

Abstract The COVID-19 pandemic has given rise to post-acute cognitive symptoms, often described as ‘brain fog’. To comprehensively grasp the extent of these issues, we conducted a study integrating traditional neuropsychological assessments with experimental tasks targeting attention control, working memory, and long-term three domains most commonly associated We enrolled 33 post-COVID patients, all self-reporting difficulties, matched control group (N = 27) for psychological assessments. Our findings revealed significant deficits in patients across both measurements tasks, evidencing reduced performance involving interference resolution selective sustained attention. Mild executive function naming impairments also emerged from assessment. Notably, 61% reported prospective memory failures daily life, aligning our recruitment focus. Furthermore, patient showed alterations psycho-affective domain, indicating complex interplay between factors, which could point non-cognitive determinant subjectively experienced changes following COVID-19. In summary, offers valuable insights into challenges faced by individuals recovering COVID-19, stressing importance comprehensive evaluations supporting individuals.

Language: Английский

Citations

9