Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 28, 2025
Introduction
Multiple
sclerosis
(MS)
is
a
chronic
neurodegenerative
disease
that
affects
over
2.8
million
people
globally,
leading
to
significant
motor
and
non-motor
symptoms.
Effective
monitoring
critical
for
improving
patient
outcomes
but
often
hindered
by
the
limitations
of
infrequent
clinical
assessments.
Digital
remote
tools
leveraging
big
data
AI
offer
new
opportunities
track
symptoms
in
real
time
detect
progression.
Methods
This
narrative
review
explores
recent
advancements
digital
MS.
We
conducted
PubMed
search
collect
original
studies
aimed
at
evaluating
use
and/or
pwMS.
focus
on
techniques
applied
from
wearable
sensors,
smartphones,
other
connected
devices,
as
well
AI-based
methods
analysis
data.
Results
Wearable
sensors
machine
learning
algorithms
show
promise
symptoms,
such
fall
risk
gait
disturbances.
Many
have
demonstrated
their
reliability
not
only
settings
independent
execution
assessments
patients,
also
passive
during
everyday
life.
Cognitive
monitoring,
although
less
developed,
has
seen
progress
with
AI-driven
automate
scoring
neuropsychological
tests
analyse
keystroke
dynamics.
However,
cognitive
still
underdeveloped,
compared
Some
preliminary
evidence
suggests
application
understudied
aspects
MS
(namely
sleep
circadian
autonomic
patterns)
may
provide
novel
insights.
Conclusion
Advances
exciting
possibilities
management
potential
revolutionize
care
providing
continuous,
long-term
granular
both
While
promising
results
been
demonstrated,
larger-scale
more
robust
validation
are
needed
fully
integrate
these
into
practice
generalise
wider
population.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(4), P. 3407 - 3407
Published: Feb. 15, 2023
Technological
innovation
has
become
an
integral
aspect
of
our
daily
life,
such
as
wearable
and
information
technology,
virtual
reality
the
Internet
Things
which
have
contributed
to
transforming
healthcare
business
operations.
Patients
will
now
a
broader
range
more
mindful
choices
experience
new
era
with
patient-centric
culture.
Digital
transformation
determines
personal
institutional
health
care.
This
paper
aims
analyse
changes
taking
place
in
field
due
digital
transformation.
For
this
purpose,
systematic
bibliographic
review
is
performed,
utilising
Scopus,
Science
Direct
PubMed
databases
from
2008
2021.
Our
methodology
based
on
approach
by
Wester
Watson,
classify
related
articles
concept-centric
method
ad
hoc
classification
system
identify
categories
used
describe
areas
literature.
The
search
was
made
during
August
2022
identified
5847
papers,
321
fulfilled
inclusion
criteria
for
further
process.
Finally,
removing
adding
additional
studies,
we
ended
287
grouped
into
five
themes:
technology
health,
educational
impact
e-health,
acceptance
telemedicine
security
issues.
Sensors,
Journal Year:
2022,
Volume and Issue:
22(15), P. 5918 - 5918
Published: Aug. 8, 2022
Digital
twins
(DTs)
play
a
vital
role
in
revolutionising
the
healthcare
industry,
leading
to
more
personalised,
intelligent,
and
proactive
healthcare.
With
evolution
of
personalised
healthcare,
there
is
significant
need
represent
virtual
replica
for
individuals
provide
right
type
care
way
at
time.
Therefore,
this
paper,
we
surveyed
concept
personal
digital
twin
(PDT)
as
an
enhanced
version
DT
with
actionable
insight
capabilities.
In
particular,
PDT
can
bring
value
patients
by
enabling
accurate
decision
making
proper
treatment
selection
optimisation.
Then,
explored
progression
revolutionary
technology
research
industry.
However,
although
several
works
have
been
performed
smart
using
DT,
still
early
stage.
Consequently,
believe
that
work
be
step
towards
industry
guiding
design
industrial
systems.
Accordingly,
introduced
reference
framework
empowers
PDTs
bringing
together
existing
advanced
technologies
(i.e.,
blockchain,
AI).
described
some
selected
use
cases,
including
mitigation
COVID-19
contagion,
survivor
follow-up
care,
medicine,
osteoporosis
prevention,
cancer
nutrition.
Finally,
identified
further
challenges
pave
paradigm
toward
Journal of Medical Internet Research,
Journal Year:
2022,
Volume and Issue:
24(8), P. e37641 - e37641
Published: Aug. 16, 2022
Background
Although
most
digital
twin
(DT)
applications
for
health
care
have
emerged
in
precision
medicine,
DTs
can
potentially
support
the
overall
process.
(twinned
systems,
processes,
and
products)
be
used
to
optimize
flows,
improve
performance,
outcomes,
experiences
of
patients,
doctors,
other
stakeholders
with
minimal
risk.
Objective
This
paper
aims
review
DT
products,
processes
as
well
analyze
potential
these
improving
management
challenges
associated
this
emerging
technology.
Methods
We
performed
a
rapid
literature
reported
available
studies
on
their
management.
searched
5
databases
published
between
January
2002
2022
included
peer-reviewed
written
English.
excluded
reporting
usage
practice
(organ
transplant,
etc).
Studies
were
analyzed
based
contribution
toward
technology
user
experience
from
human
factors
systems
engineering
perspectives,
accounting
type
impact
(product,
process,
or
performance/system
level).
Challenges
related
adoption
also
summarized.
Results
The
DT-related
aimed
at
managing
been
growing
over
time
0
17
2022,
7
2021
(N=17
studies).
findings
categorized
by
(system:
n=8;
process:
n=5;
product:
n=4)
contributions
functions.
identified
4
main
functions
including
safety
(n=3),
information
(n=2),
well-being
promotion
operational
control
(n=9).
avoid
unintended
unexpected
harm
people
during
provision
processes.
They
help
identify
crisis-related
threats
system
impacts.
In
addition,
ensure
privacy,
security,
real-time
access
all
stakeholders.
Furthermore,
they
are
beneficial
empowering
self-care
abilities
enabling
practices
providing
high
efficiency
levels
ensuring
that
facilities
run
smoothly
offer
high-quality
every
patient.
Conclusions
use
is
an
topic.
seen
limited
supporting
However,
increasingly
being
patient
organized
system.
Thus,
further
aiming
address
performance
should
investigate
such
technologies
embed
ergonomics
principles
better
design
more
successful
doctor
experiences.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Early-stage
disease
detection,
particularly
in
Point-Of-Care
(POC)
wearable
formats,
assumes
pivotal
role
advancing
healthcare
services
and
precision-medicine.
Public
benefits
of
early
detection
extend
beyond
cost-effectively
promoting
outcomes,
to
also
include
reducing
the
risk
comorbid
diseases.
Technological
advancements
enabling
POC
biomarker
recognition
empower
discovery
new
markers
for
various
health
conditions.
Integration
wearables
with
intelligent
frameworks
represents
ground-breaking
innovations
automation
operations,
conducting
advanced
large-scale
data
analysis,
generating
predictive
models,
facilitating
remote
guided
clinical
decision-making.
These
substantially
alleviate
socioeconomic
burdens,
creating
a
paradigm
shift
diagnostics,
revolutionizing
medical
assessments
technology
development.
This
review
explores
critical
topics
recent
progress
development
1)
systems
solutions
physiological
monitoring,
as
well
2)
discussing
current
trends
adoption
smart
technologies
within
settings
developing
biological
assays,
ultimately
3)
exploring
utilities
platforms
discovery.
Additionally,
translation
from
research
labs
broader
applications.
It
addresses
associated
risks,
biases,
challenges
widespread
Artificial
Intelligence
(AI)
integration
diagnostics
systems,
while
systematically
outlining
potential
prospects,
challenges,
opportunities.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(9), P. e19390 - e19390
Published: Aug. 24, 2023
This
article
aims
to
make
a
bibliometric
literature
review
using
systematic
scientific
mapping
and
content
analysis
of
digital
twins
in
healthcare
know
the
evolution,
domain,
keywords,
type,
kind
purpose
twin's
implementation
healthcare,
so
consolidation
future
improvement
existing
knowledge
can
be
made
gaps
for
new
studies
identified.
The
increase
publications
is
quite
recent
it
still
concentrated
domain
technology
sources.
subject
majorly
patient's
twin
group
precision
medicine
aspects,
issues
and/or
policies
subgroups,
although
keywords
mirror
only
at
side.
Digital
are
probably
stepping
out
infancy
phase.
On
other
hand,
hospital
device
facilities
management
subgroups
more
mature
with
all
gathered
from
manufacturing
sector.
There
an
absence
some
publication's
types
general,
care
subgroup
no
whole
body
or
was
reported.
Based
on
presented
arguments,
guidelines
research
were
presented:
advance
creation
general
frameworks,
not
as
much
explored,
groups
already
but
that
need
advancement
achieve
main
goals
human
resolved.
BMJ Health & Care Informatics,
Journal Year:
2024,
Volume and Issue:
31(1), P. e100914 - e100914
Published: April 1, 2024
Background
Technological
devices
such
as
smartphones,
wearables
and
virtual
assistants
enable
health
data
collection,
serving
digital
alternatives
to
conventional
biomarkers.
We
aimed
provide
a
systematic
overview
of
emerging
literature
on
‘digital
biomarkers,’
covering
definitions,
features
citations
in
biomedical
research.
Methods
analysed
all
articles
PubMed
that
used
biomarker(s)’
title
or
abstract,
considering
any
study
involving
humans
review,
editorial,
perspective
opinion-based
up
8
March
2023.
systematically
extracted
characteristics
publications
research
studies,
definitions
biomarkers’
mentioned.
described
the
most
influential
biomarkers
their
using
thematic
categorisations
Food
Drug
Administration
Biomarkers,
EndpointS
other
Tools
framework
(ie,
type,
collection
method,
purpose
biomarker),
analysing
structural
similarity
by
performing
text
citation
analyses.
Results
identified
415
biomarker’
between
2014
2023
(median
2021).
The
majority
(283
articles;
68%)
were
primary
Notably,
287
(69%)
did
not
definition
Among
128
with
there
127
different
ones.
Of
these,
78
considered
56
50
23
included
three
components.
Those
had
median
6
citations,
top
10
each
presenting
distinct
definitions.
Conclusions
vary
significantly,
indicating
lack
consensus
this
field.
Our
highlights
key
defining
characteristics,
which
could
guide
development
more
harmonised
accepted
definition.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1101 - 1101
Published: Nov. 11, 2024
This
review
examines
the
significant
influence
of
Digital
Twins
(DTs)
and
their
variant,
Human
(DHTs),
on
healthcare
field.
DTs
represent
virtual
replicas
that
encapsulate
both
medical
physiological
characteristics-such
as
tissues,
organs,
biokinetic
data-of
patients.
These
models
facilitate
a
deeper
understanding
disease
progression
enhance
customization
optimization
treatment
plans
by
modeling
complex
interactions
between
genetic
factors
environmental
influences.
By
establishing
dynamic,
bidirectional
connections
physical
objects
digital
counterparts,
these
technologies
enable
real-time
data
exchange,
thereby
transforming
electronic
health
records.
Leveraging
increasing
availability
extensive
historical
datasets
from
clinical
trials
real-world
sources,
AI
can
now
generate
comprehensive
predictions
future
outcomes
for
specific
patients
in
form
AI-generated
DTs.
Such
also
offer
insights
into
potential
diagnoses,
progression,
responses.
remarkable
paves
way
precision
medicine
personalized
health,
allowing
high-level
individualized
interventions
therapies.
However,
integration
faces
several
challenges,
including
security,
accessibility,
bias,
quality.
Addressing
obstacles
is
crucial
to
realizing
full
DHTs,
heralding
new
era
personalized,
precise,
accurate
medicine.