Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review DOI Open Access
Anna Giulia Bottaccioli, Mauro Bologna, Francesco Bottaccioli

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3932 - 3932

Published: April 1, 2022

Today, it is possible to investigate the biological paths and mechanisms that link mental life life. Emotions, feelings, desires, cognitions influence systems. In recent decades, psychoneuroendocrinoimmunology research has highlighted routes linking psyche-brain-immune Recently, epigenetics shown molecular by which stress states modulate information contained in genome. This shapes a new paradigm considering human being as whole, integrating biology psychology. will allow us progress towards personalized precision medicine, deeply changing medical psychological sciences clinical practice. this paper, we recognize leading on both bidirectional relations between psyche-brain-immunity consequences of states.

Language: Английский

Prevalence of depression and its correlates among undergraduate health science students in Mogadishu, Somalia: a cross-sectional study DOI Creative Commons
Bashiru Garba,

Samiro Ali Mohamed,

Mohd Sapawi Mohamed

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 1, 2025

Abstract Background Depression among undergraduate health science students is increasingly recognized as a significant public issue globally. These face immense academic pressure, often leading to stress and mental exhaustion, particularly for studying in humanitarian crisis situation. However, there scarcity of information this regard higher education institutions Somalia. Hence, investigation was conducted assess the prevalence depression its correlates Methods A cross-sectional study on 321 from some universities Mogadishu, The data collected medicine, nursing midwifery, laboratory at SIMAD university, Banadir Mogadishu university Jamhuriya all located Mogadishu. Simple random sampling based class list used select participants web-based self-administered Patient Health Questionnaire (PHQ-9) screen depression. were cleaned checked completeness before exporting into SPSS version 27 Statistical software analysis, where descriptive statistics well logistic regression analysis done determine independent predictors outcome variable. Significant association determined 95% confidence interval p -value < 0.05. Result 58.6%. total 41.5% (133/321) free (Normal), while 30.8% had mild depression, 27.1% moderate 0.6% severe Analysis between sociodemographic variables depressive state participant showed statistical significance ( = 0.045) course study. Students midwifery highest case with 68.6% (59/86), followed by 66.7% (30/45), 52.3% (34/65), medicine having least number depressed 52.0% (65/125). Similarly, gender also found be statistically 0.001) female 65% which 41.1% studied. Conclusion high positively associated gender, trouble authorities, emotional problems, experience sexual abuse or violence. routine screening monitoring students’ campus providing services necessary address growing problem.

Language: Английский

Citations

1

Investigating the impact of endocrine-disrupting compounds on antepartum mental health at the Nexus of genetic insights and maternal-fetal outcomes: A prospective study DOI

S Aishwarya,

V.M. Vinodhini,

P. Renuka

et al.

General Hospital Psychiatry, Journal Year: 2025, Volume and Issue: 94, P. 174 - 183

Published: March 13, 2025

Language: Английский

Citations

1

Mental health expert’s perspective on risk and protective factors of suicide ideation in Patients with OCD and depression DOI Creative Commons

Roma Sarwar,

Alia Asmat

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

Suicidal ideation and behavior present profound challenges in mental health care, particularly among individuals contending with Depression Obsessive-Compulsive Disorder (OCD). While existing research has elucidated the intricate pathways through which depression OCD independently contribute to suicide risk, there remains a critical gap understanding interplay between these disorders shaping suicidal tendencies. This qualitative study aims address this by exploring expert's perspective about risk protective factors associated diagnosed OCD. Through semi-structured interviews experts, thematic analysis was employed uncover cognitive, emotional, environmental stressors influencing thoughts behaviors clinical population. Findings reveal multifaceted cognitive vulnerabilities, adverse childhood experiences, familial as prominent factors, while coping skills, social support, religious beliefs emerged key factors. By illuminating complex of contributing context comorbid OCD, provides valuable insights for development targeted interventions aimed at mitigating improving outcomes affected individuals.

Language: Английский

Citations

1

Predicting the depression in university students using stacking ensemble techniques over oversampling method DOI Creative Commons
Alfredo Daza Vergaray, Juan Carlos Herrera, Juana Bobadilla Cornelio

et al.

Informatics in Medicine Unlocked, Journal Year: 2023, Volume and Issue: 41, P. 101295 - 101295

Published: Jan. 1, 2023

Depression is that mental health disorder characterized by constant sadness for approximately 2 weeks, in which it generates an inability to do daily activities, and those affected lose interest doing the things they previously enjoyed. About 1 billion people have disorders more than 300 million depression globally. To predict depression, use of machine learning techniques essential, being helpful obtaining automatic processes creating models help analyze solve a problem. The objective study was propose method 3 combined based on Stacking university students public university. dataset composed Computer Systems Engineering from (n = 284). Then cleaning pre-processing performed, where data reviewed using Python program. In balancing data, were divided into 5 values obtained oversampling distributing according condition. we proceeded partition balanced while Cross validation training. For model evaluation, 4 independent algorithms used, these proposed. Of proposed Ensemble achieved best Accuracy ROC Curve score -micro score-macro with 94.69% 100.00%. same way respect sensitivity, accuracy F1-Score, 94.22%, 94.09% 94.12% respectively. This emphasizes application detect early Peru. With this technology, when method, possible observe improvement performance process prediction unlike performing algorithms.

Language: Английский

Citations

20

The Benefits of Prebiotics and Probiotics on Mental Health DOI Open Access

Karlyle Bistas,

Jean Paul Tabet

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 9, 2023

In individuals with depression and anxiety, the composition or alteration of their gut microbiota can significantly affect psychological symptoms. Articles for this study were selected using PubMed NCBI (National Center Biotechnology Information) following search terms: “gut microbiota,” “depression,” “anxiety,” “probiotics,” “prebiotics.” These studies evaluated decrease in symptoms anxiety due to treatment probiotics prebiotics. Only papers published after 2015 included. There was a significant relationship between presence variation anxiety. Treatment prebiotics improved these mental health conditions. This literature review examines how different altering individuals’ correlates may severity disorders by microbiota.

Language: Английский

Citations

17

Relationship of depression and sleep quality, diseases and general characteristics DOI Open Access
Yan Jiang, Tao Jiang, Litao Xu

et al.

World Journal of Psychiatry, Journal Year: 2022, Volume and Issue: 12(5), P. 722 - 738

Published: May 13, 2022

Depression is the most common type of depressive disorder. The sleep disorder associated with depression insomnia. Insomnia and are closely related.To investigate relationship designed questionnaire items depression, analyze related factors depression.Questionnaire included Patient Health Questionnaire-9 (PHQ-9) Pittsburgh quality index (PSQI), 12 kinds diseases, 8 general characteristics, 20 insomnia totally 56 were filled out by 411 patients enrolled.All 9 PHQ-9, 6 components PSQI (except duration), education, living situation, exercise, years insomnia, western medicine treatment, Chinese psychotherapy, treatment expected to treat psychological counseling, habit 1 h before bed, lunch break, diagnosed coronary heart disease, mental illness showed significant difference between without group. By univariate analysis multivariate analysis. odds ratio disease (P = 0.01) difference. Their ratios 0.71 (0.55, 0.93), 2.09 (1.32, 3.31), 0.76 (0.63, 0.91), 0.89 (0.81, 0.98), 0.32 (0.17, 0.60), 0.43 (0.23, 0.79).We demonstrated that affect depression.

Language: Английский

Citations

27

The Social Determinants of Mental Illness: A Rapid Review of Systematic Reviews DOI
Leigh Huggard, Rachel Murphy, Cliódhna O’Connor

et al.

Issues in Mental Health Nursing, Journal Year: 2023, Volume and Issue: 44(4), P. 302 - 312

Published: March 27, 2023

Previous research agendas have prioritised the role of biological determinants in mental illness aetiology. This is particular concern, as endorsing has been shown to promote negative attitudes towards people with illness. The aim this review was provide an overview high-quality evidence social A rapid systematic reviews conducted. Five databases were searched: Embase, Medline, Academic Search Complete, CINAHL Plus, and PsycINFO. Systematic or meta-analyses that described any determinant illness, published peer-review journals English, focussed on human participants included. Preferred Reporting Items for Review Meta-Analyses (PRISMA) guidelines applied selection procedure. Thirty-seven deemed eligible narrative synthesis. Determinants identified included conflict, violence maltreatment, life events experiences, racism discrimination, culture migration, interaction support, structural policies inequality, financial factors, employment housing living conditions, demographic factors. We recommend health nurses ensure adequate support be provided those affected by evidenced

Language: Английский

Citations

15

Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study DOI Creative Commons
Thaís da Silva Sabião, Luiz Antônio Alves de Menezes-Júnior, Aline Priscila Batista

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 22, 2024

Abstract Mental disorders are intricate and multifaceted encompass social, economic, environmental, biological factors. This study aimed to explore the potential association between vitamin D deficiency anxiety depression symptoms in adults, considering role of receptor gene polymorphism FokI (rs2228570). was a population-based cross-sectional with stratified cluster sampling, evaluating (AS) (DS) 1637 adults. Vitamin levels were measured using electrochemiluminescence considered deficient when < 20 ng/mL healthy population or 30 at-risk groups. Genotyping performed real-time polymerase chain reaction TaqMan probes. The prevalence rates AS, DS, 23.5%, 15.8%, 30.9%, respectively. No direct observed AS DS. However, interaction analysis revealed combined effect for DS but not AS. Individuals one two copies altered allele exhibited higher than individuals homozygous wild-type sufficiency. associated

Language: Английский

Citations

6

Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review DOI Creative Commons
Alec Jamieson, Christine A. Leonards, Christopher G. Davey

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 25, 2024

Major depressive disorder (MDD) is marked by altered processing of emotional stimuli, including facial expressions. Recent neuroimaging research has attempted to investigate how these stimuli alter the directional interactions between brain regions in those with MDD; however, methodological heterogeneity made identifying consistent effects difficult. To address this, we systematically examined studies investigating MDD-associated differences present effective connectivity during We searched five databases: PsycINFO, EMBASE, PubMed, Scopus, and Web Science, using a preregistered protocol (registration number: CRD42021271586). Of 510 unique screened, 17 met our inclusion criteria. These identified that compared healthy controls, participants MDD demonstrated (1) reduced from dorsolateral prefrontal cortex amygdala negatively valenced expressions, (2) increased inhibitory ventromedial happy Most anterior cingulate noted their connectivity; precise nature was inconsistent studies. As such, commonalities observed across modalities warrant careful investigation determine specificity particular subregions Future examining longitudinal changes associated treatment response may provide important insights into mechanisms underpinning therapeutic interventions, thus enabling more targeted strategies.

Language: Английский

Citations

5

Stress circuitry: mechanisms behind nervous and immune system communication that influence behavior DOI Creative Commons

Rose L. Tong,

Ubaidah N. Kahn,

Laura A. Grafe

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 29, 2023

Inflammatory processes are increased by stress and contribute to the pathology of mood disorders. Stress is thought primarily induce inflammation through peripheral central noradrenergic neurotransmission. In healthy individuals, these pro-inflammatory effects countered glucocorticoid signaling, which also activated stress. chronically stressed anti-inflammatory glucocorticoids impaired, allowing go unchecked. Mechanisms underlying this resistance well understood, but precise circuits molecular mechanisms increases not as known. narrative review, we summarize chronic contributes onset development stress-related We focus on neural substrates mechanisms, especially those regulated that increase inflammatory in individuals. discuss key knowledge gaps our understanding communication between nervous immune systems during considerations for future therapeutic strategies. Here highlight signaling how can Understanding crosstalk may lead novel strategies disorders and/or provide important treating immune-related diseases individuals suffering from

Language: Английский

Citations

13