International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(7), P. 3932 - 3932
Published: April 1, 2022
Today,
it
is
possible
to
investigate
the
biological
paths
and
mechanisms
that
link
mental
life
life.
Emotions,
feelings,
desires,
cognitions
influence
systems.
In
recent
decades,
psychoneuroendocrinoimmunology
research
has
highlighted
routes
linking
psyche-brain-immune
Recently,
epigenetics
shown
molecular
by
which
stress
states
modulate
information
contained
in
genome.
This
shapes
a
new
paradigm
considering
human
being
as
whole,
integrating
biology
psychology.
will
allow
us
progress
towards
personalized
precision
medicine,
deeply
changing
medical
psychological
sciences
clinical
practice.
this
paper,
we
recognize
leading
on
both
bidirectional
relations
between
psyche-brain-immunity
consequences
of
states.
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 1, 2025
Abstract
Background
Depression
among
undergraduate
health
science
students
is
increasingly
recognized
as
a
significant
public
issue
globally.
These
face
immense
academic
pressure,
often
leading
to
stress
and
mental
exhaustion,
particularly
for
studying
in
humanitarian
crisis
situation.
However,
there
scarcity
of
information
this
regard
higher
education
institutions
Somalia.
Hence,
investigation
was
conducted
assess
the
prevalence
depression
its
correlates
Methods
A
cross-sectional
study
on
321
from
some
universities
Mogadishu,
The
data
collected
medicine,
nursing
midwifery,
laboratory
at
SIMAD
university,
Banadir
Mogadishu
university
Jamhuriya
all
located
Mogadishu.
Simple
random
sampling
based
class
list
used
select
participants
web-based
self-administered
Patient
Health
Questionnaire
(PHQ-9)
screen
depression.
were
cleaned
checked
completeness
before
exporting
into
SPSS
version
27
Statistical
software
analysis,
where
descriptive
statistics
well
logistic
regression
analysis
done
determine
independent
predictors
outcome
variable.
Significant
association
determined
95%
confidence
interval
p
-value
<
0.05.
Result
58.6%.
total
41.5%
(133/321)
free
(Normal),
while
30.8%
had
mild
depression,
27.1%
moderate
0.6%
severe
Analysis
between
sociodemographic
variables
depressive
state
participant
showed
statistical
significance
(
=
0.045)
course
study.
Students
midwifery
highest
case
with
68.6%
(59/86),
followed
by
66.7%
(30/45),
52.3%
(34/65),
medicine
having
least
number
depressed
52.0%
(65/125).
Similarly,
gender
also
found
be
statistically
0.001)
female
65%
which
41.1%
studied.
Conclusion
high
positively
associated
gender,
trouble
authorities,
emotional
problems,
experience
sexual
abuse
or
violence.
routine
screening
monitoring
students’
campus
providing
services
necessary
address
growing
problem.
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 21, 2025
Suicidal
ideation
and
behavior
present
profound
challenges
in
mental
health
care,
particularly
among
individuals
contending
with
Depression
Obsessive-Compulsive
Disorder
(OCD).
While
existing
research
has
elucidated
the
intricate
pathways
through
which
depression
OCD
independently
contribute
to
suicide
risk,
there
remains
a
critical
gap
understanding
interplay
between
these
disorders
shaping
suicidal
tendencies.
This
qualitative
study
aims
address
this
by
exploring
expert's
perspective
about
risk
protective
factors
associated
diagnosed
OCD.
Through
semi-structured
interviews
experts,
thematic
analysis
was
employed
uncover
cognitive,
emotional,
environmental
stressors
influencing
thoughts
behaviors
clinical
population.
Findings
reveal
multifaceted
cognitive
vulnerabilities,
adverse
childhood
experiences,
familial
as
prominent
factors,
while
coping
skills,
social
support,
religious
beliefs
emerged
key
factors.
By
illuminating
complex
of
contributing
context
comorbid
OCD,
provides
valuable
insights
for
development
targeted
interventions
aimed
at
mitigating
improving
outcomes
affected
individuals.
Informatics in Medicine Unlocked,
Journal Year:
2023,
Volume and Issue:
41, P. 101295 - 101295
Published: Jan. 1, 2023
Depression
is
that
mental
health
disorder
characterized
by
constant
sadness
for
approximately
2
weeks,
in
which
it
generates
an
inability
to
do
daily
activities,
and
those
affected
lose
interest
doing
the
things
they
previously
enjoyed.
About
1
billion
people
have
disorders
more
than
300
million
depression
globally.
To
predict
depression,
use
of
machine
learning
techniques
essential,
being
helpful
obtaining
automatic
processes
creating
models
help
analyze
solve
a
problem.
The
objective
study
was
propose
method
3
combined
based
on
Stacking
university
students
public
university.
dataset
composed
Computer
Systems
Engineering
from
(n
=
284).
Then
cleaning
pre-processing
performed,
where
data
reviewed
using
Python
program.
In
balancing
data,
were
divided
into
5
values
obtained
oversampling
distributing
according
condition.
we
proceeded
partition
balanced
while
Cross
validation
training.
For
model
evaluation,
4
independent
algorithms
used,
these
proposed.
Of
proposed
Ensemble
achieved
best
Accuracy
ROC
Curve
score
-micro
score-macro
with
94.69%
100.00%.
same
way
respect
sensitivity,
accuracy
F1-Score,
94.22%,
94.09%
94.12%
respectively.
This
emphasizes
application
detect
early
Peru.
With
this
technology,
when
method,
possible
observe
improvement
performance
process
prediction
unlike
performing
algorithms.
Cureus,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 9, 2023
In
individuals
with
depression
and
anxiety,
the
composition
or
alteration
of
their
gut
microbiota
can
significantly
affect
psychological
symptoms.
Articles
for
this
study
were
selected
using
PubMed
NCBI
(National
Center
Biotechnology
Information)
following
search
terms:
“gut
microbiota,”
“depression,”
“anxiety,”
“probiotics,”
“prebiotics.”
These
studies
evaluated
decrease
in
symptoms
anxiety
due
to
treatment
probiotics
prebiotics.
Only
papers
published
after
2015
included.
There
was
a
significant
relationship
between
presence
variation
anxiety.
Treatment
prebiotics
improved
these
mental
health
conditions.
This
literature
review
examines
how
different
altering
individuals’
correlates
may
severity
disorders
by
microbiota.
World Journal of Psychiatry,
Journal Year:
2022,
Volume and Issue:
12(5), P. 722 - 738
Published: May 13, 2022
Depression
is
the
most
common
type
of
depressive
disorder.
The
sleep
disorder
associated
with
depression
insomnia.
Insomnia
and
are
closely
related.To
investigate
relationship
designed
questionnaire
items
depression,
analyze
related
factors
depression.Questionnaire
included
Patient
Health
Questionnaire-9
(PHQ-9)
Pittsburgh
quality
index
(PSQI),
12
kinds
diseases,
8
general
characteristics,
20
insomnia
totally
56
were
filled
out
by
411
patients
enrolled.All
9
PHQ-9,
6
components
PSQI
(except
duration),
education,
living
situation,
exercise,
years
insomnia,
western
medicine
treatment,
Chinese
psychotherapy,
treatment
expected
to
treat
psychological
counseling,
habit
1
h
before
bed,
lunch
break,
diagnosed
coronary
heart
disease,
mental
illness
showed
significant
difference
between
without
group.
By
univariate
analysis
multivariate
analysis.
odds
ratio
disease
(P
=
0.01)
difference.
Their
ratios
0.71
(0.55,
0.93),
2.09
(1.32,
3.31),
0.76
(0.63,
0.91),
0.89
(0.81,
0.98),
0.32
(0.17,
0.60),
0.43
(0.23,
0.79).We
demonstrated
that
affect
depression.
Issues in Mental Health Nursing,
Journal Year:
2023,
Volume and Issue:
44(4), P. 302 - 312
Published: March 27, 2023
Previous
research
agendas
have
prioritised
the
role
of
biological
determinants
in
mental
illness
aetiology.
This
is
particular
concern,
as
endorsing
has
been
shown
to
promote
negative
attitudes
towards
people
with
illness.
The
aim
this
review
was
provide
an
overview
high-quality
evidence
social
A
rapid
systematic
reviews
conducted.
Five
databases
were
searched:
Embase,
Medline,
Academic
Search
Complete,
CINAHL
Plus,
and
PsycINFO.
Systematic
or
meta-analyses
that
described
any
determinant
illness,
published
peer-review
journals
English,
focussed
on
human
participants
included.
Preferred
Reporting
Items
for
Review
Meta-Analyses
(PRISMA)
guidelines
applied
selection
procedure.
Thirty-seven
deemed
eligible
narrative
synthesis.
Determinants
identified
included
conflict,
violence
maltreatment,
life
events
experiences,
racism
discrimination,
culture
migration,
interaction
support,
structural
policies
inequality,
financial
factors,
employment
housing
living
conditions,
demographic
factors.
We
recommend
health
nurses
ensure
adequate
support
be
provided
those
affected
by
evidenced
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 22, 2024
Abstract
Mental
disorders
are
intricate
and
multifaceted
encompass
social,
economic,
environmental,
biological
factors.
This
study
aimed
to
explore
the
potential
association
between
vitamin
D
deficiency
anxiety
depression
symptoms
in
adults,
considering
role
of
receptor
gene
polymorphism
FokI
(rs2228570).
was
a
population-based
cross-sectional
with
stratified
cluster
sampling,
evaluating
(AS)
(DS)
1637
adults.
Vitamin
levels
were
measured
using
electrochemiluminescence
considered
deficient
when
<
20
ng/mL
healthy
population
or
30
at-risk
groups.
Genotyping
performed
real-time
polymerase
chain
reaction
TaqMan
probes.
The
prevalence
rates
AS,
DS,
23.5%,
15.8%,
30.9%,
respectively.
No
direct
observed
AS
DS.
However,
interaction
analysis
revealed
combined
effect
for
DS
but
not
AS.
Individuals
one
two
copies
altered
allele
exhibited
higher
than
individuals
homozygous
wild-type
sufficiency.
associated
Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 25, 2024
Major
depressive
disorder
(MDD)
is
marked
by
altered
processing
of
emotional
stimuli,
including
facial
expressions.
Recent
neuroimaging
research
has
attempted
to
investigate
how
these
stimuli
alter
the
directional
interactions
between
brain
regions
in
those
with
MDD;
however,
methodological
heterogeneity
made
identifying
consistent
effects
difficult.
To
address
this,
we
systematically
examined
studies
investigating
MDD-associated
differences
present
effective
connectivity
during
We
searched
five
databases:
PsycINFO,
EMBASE,
PubMed,
Scopus,
and
Web
Science,
using
a
preregistered
protocol
(registration
number:
CRD42021271586).
Of
510
unique
screened,
17
met
our
inclusion
criteria.
These
identified
that
compared
healthy
controls,
participants
MDD
demonstrated
(1)
reduced
from
dorsolateral
prefrontal
cortex
amygdala
negatively
valenced
expressions,
(2)
increased
inhibitory
ventromedial
happy
Most
anterior
cingulate
noted
their
connectivity;
precise
nature
was
inconsistent
studies.
As
such,
commonalities
observed
across
modalities
warrant
careful
investigation
determine
specificity
particular
subregions
Future
examining
longitudinal
changes
associated
treatment
response
may
provide
important
insights
into
mechanisms
underpinning
therapeutic
interventions,
thus
enabling
more
targeted
strategies.
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 29, 2023
Inflammatory
processes
are
increased
by
stress
and
contribute
to
the
pathology
of
mood
disorders.
Stress
is
thought
primarily
induce
inflammation
through
peripheral
central
noradrenergic
neurotransmission.
In
healthy
individuals,
these
pro-inflammatory
effects
countered
glucocorticoid
signaling,
which
also
activated
stress.
chronically
stressed
anti-inflammatory
glucocorticoids
impaired,
allowing
go
unchecked.
Mechanisms
underlying
this
resistance
well
understood,
but
precise
circuits
molecular
mechanisms
increases
not
as
known.
narrative
review,
we
summarize
chronic
contributes
onset
development
stress-related
We
focus
on
neural
substrates
mechanisms,
especially
those
regulated
that
increase
inflammatory
in
individuals.
discuss
key
knowledge
gaps
our
understanding
communication
between
nervous
immune
systems
during
considerations
for
future
therapeutic
strategies.
Here
highlight
signaling
how
can
Understanding
crosstalk
may
lead
novel
strategies
disorders
and/or
provide
important
treating
immune-related
diseases
individuals
suffering
from