Brain Sciences,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1346 - 1346
Published: Oct. 4, 2022
Sex
(the
biological
attributes
of
females
and
males)
gender
(socially
constructed
roles,
behaviours,
identities)
both
affect
molecular
cellular
processes,
protective
vulnerability
factors,
social
relational
life
[...].
Addictive Behaviors,
Journal Year:
2023,
Volume and Issue:
144, P. 107757 - 107757
Published: May 21, 2023
Emotion
dysregulation
(ED)
is
a
transdiagnostic
variable
that
accounts
for
the
onset
and
maintenance
of
mental
health
disorders.
The
interplay
between
ED,
cannabis
use
has
not
been
appraised
in
young
adult
population
whether
there
are
sex-dependent
effects
yet
to
be
examined.
This
study
looked
at
ED
mediates
association
past-month
health,
while
considering
sex
as
moderator.2,762
(64.2%
women)
undergraduate
Spanish
students
completed
an
online
battery.
Among
others,
they
fulfilled
Depression
Anxiety
Stress
Scale-21
(DASS-21)
Difficulties
Regulation
Scale
(DERS-28).
A
two-way
ANOVA
assessed
on
participants'
DASS-21
scores.
set
moderated
mediations
tested
indirect
effect
through
DERS
differed
by
sex.Past-month
female
users
showed
higher
levels
depression,
anxiety
stress
(M
=
51.10,
SD
26.72)
than
did
men
[(M
33.76,
20.31);
F(1,
2758)
5.119,
p
=.024,
η2p
=.002].
In
adults
only,
was
mediated
(total
score),
non-acceptance
emotional
responses,
lack
control,
difficulties
engaging
goal-directed
behavior,
clarity
(all
p's
<
0.005)
CONCLUSIONS:
Findings
indicate
importance
assessment
intervention
practices.
Interventions
targeting
may
particularly
effective
users.
Current Addiction Reports,
Journal Year:
2024,
Volume and Issue:
11(3), P. 371 - 383
Published: March 14, 2024
Abstract
Purpose
of
Review
This
narrative
review
provides
an
update
our
knowledge
on
the
relation
between
heavy
cannabis
use
and
disorder
(CUD)
brain
based
(f)MRI
studies
conducted
in
past
5
years.
Recent
Findings
Heavy
CUD
are
associated
with
structural
changes—particularly
volume—as
well
as
altered
resting-state
functional
connectivity
(RSFC)
several
networks
regions.
Task-based
fMRI
reveal
activity
users
compared
to
controls,
but
consistency
results
is
domain
dependent.
Heaviness
use,
status,
age,
sex,
tobacco
co-use
important
potential
moderators
effects
brain.
Summary
differences
structure
function,
causality
remains
unclear,
long-term
following
abstinence
require
further
investigation.
Considering
crucial
assess
individual
impact
use.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(4), P. 1630 - 1630
Published: Feb. 18, 2024
Significant
clinical
overlap
exists
between
mental
health
and
substance
use
disorders,
especially
among
women.
The
purpose
of
this
research
is
to
leverage
an
AutoML
(Automated
Machine
Learning)
interface
predict
distinguish
co-occurring
(MH)
disorders
(SUD)
By
employing
various
modeling
algorithms
for
binary
classification,
including
Random
Forest,
Gradient
Boosted
Trees,
XGBoost,
Extra
SGD,
Deep
Neural
Network,
Single-Layer
Perceptron,
K
Nearest
Neighbors
(grid),
a
super
learning
model
(constructed
by
combining
the
predictions
Forest
XGBoost
model),
aims
provide
healthcare
practitioners
with
powerful
tool
earlier
identification,
intervention,
personalised
support
women
at
risk.
present
presents
machine
(ML)
methodology
more
accurately
predicting
co-occurrence
in
women,
utilising
Treatment
Episode
Data
Set
Admissions
(TEDS-A)
from
year
2020
(n
=
497,175).
A
was
constructed
model.
demonstrated
promising
predictive
performance
MH
SUD
AUC
0.817,
Accuracy
0.751,
Precision
0.743,
Recall
0.926
F1
Score
0.825.
accurate
prediction
models
can
substantially
facilitate
prompt
identification
implementation
intervention
strategies.
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 5, 2023
In
the
US
over
past
decade,
there
has
been
a
steady
increase
in
marijuana
use
rates
among
adolescents,
part
due
to
legalization
laws.
It
is
unknown
whether
these
greater
are
associated
with
rising
of
adolescent
suicide
ideation
and
behaviors
(plan
attempt)
or
associations
differ
by
gender
race/ethnicity.To
determine
ideation/behaviors
adolescents
if
differences
exist
race/ethnicity.Using
2015-2019
National
Surveys
on
Drug
Use
Health,
we
assessed
relationship
between
frequency
(12-17,
n
=
73,986).
We
also
examined
association
disorder
(MUD)
race/ethnicity.
Marijuana
year
was
categorized
as
no
use,
non-weekly
weekly-plus
use.
estimated
multivariable
logistic
regression
models,
adjusting
for
sociodemographics,
health
status,
common
co-occurring
behavioral
disorders,
criminal
history.
For
interpretability,
coefficients
were
converted
into
predicted
probabilities
using
predictive
margin
methods.In
primary
analyses,
had
higher
any
ideation,
61.5%
(+
10.4
percentage-points;
95%
CI:
7.0-13.8%)
64.5%
13.4
9.1-17.7%),
relative
(51.1%).
Non-weekly
plan
58.2%
11.8
7.8-16.0%)
59.0%
12.6
6.4-18.9%),
attempt,
42.0%
11.6
7.0-16.2%)
47.3%
16.9
10.9-22.9%)
compared
(46.4
30.4%,
respectively).
Similar
results
found
MUD
(all
p
<
0.05).
Positive
persisted
males
females
well
White,
Black,
Latinx
0.05).Between
2015
2019,
increased
that
used
marijuana.
As
legalized
more
states,
public
efforts
needed
curb
increases
better
understand
causal
linkages
ideation/behaviors.
International Journal of Mental Health and Addiction,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 29, 2023
Abstract
Time
perception
received
growing
interest
in
psychiatry
for
its
psychopathological
implications.
Cannabis
use
can
cause
a
subjective
experience
of
temporal
alteration
and
increases
the
risk
emergence
mental
illnesses
such
as
psychotic
mood
disorders.
In
this
framework,
we
systematically
reviewed
findings
regarding
clinical,
cognitive,
neurobiological
correlates
time
alterations
due
to
cannabis
consumption.
According
preclinical
results,
exerts
dose-dependent
overestimation,
associated
with
motor
inhibition
circadian
alterations.
Clinical
results
reported
that
impair
estimation
reproduction
abilities,
causing
fragmentation
depersonalization
symptoms.
The
timing
mediated
by
might
depend
on
dopaminergic
indirect
action
structural,
functional,
metabolic
cerebello-thalamo-cortical
circuit.
Despite
potential
interest,
however,
only
few
studies
explored
link
between
cannabis-induced
processing
psychiatric
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
Abstract
Heavy
and
daily
use
of
cannabis
with
high
contents
Δ9-tetrahydrocannabinol
(THC)
during
adolescence
is
associated
an
increased
risk
developing
psychotic
disorders
later
in
life.
Here,
we
have
generated
a
mouse
model
THC
exposure
that
exhibits
impairments
social
interaction
vulnerability
to
develop
sensorimotor
gating
deficiencies
comparable
those
previously
described
among
heavy
consumers.
Importantly,
provide
evidence
on
long-term
cortico-striatal
dysconnectivity
induced
by
its
correlation
impaired
interactions
occurring
adulthood.
Moreover,
observed
long-lasting
molecular
alterations
key
elements
regulate
the
mesolimbic
dopaminergic
system,
namely
balance
between
dopamine
D2,
adenosine
A2A,
cannabinoid
CB1
receptors
striatum
treated
mice.
Together,
these
findings
contribute
better
understanding
neurobiological
bases
deleterious
effects
abuse
point
D2R,
A2AR
CB1R
equilibrium
as
potential
target
reverse
or
prevent
effects.