Characteristics of immunocompetent cells in the testicles of different age group patients with COVID-19 DOI Open Access
Grigory Demyashkin, Dmitry V. Boldyrev, Matvey Vadyukhin

et al.

Kazan medical journal, Journal Year: 2024, Volume and Issue: 105(4), P. 533 - 542

Published: July 25, 2024

BACKGROUND: There is an opinion that the new coronavirus infection COVID-19 can initiate development of a local inflammatory reaction in testicles, which leads to damage spermatogenic epithelial cells and decrease fertility patients long term. AIM: Morphofunctional assessment immunocompetent testicles with depending on age. MATERIAL AND METHODS: Based anamnestic, clinical morphological data, groups were formed, each included subgroups according age periodization World Health Organization: first group who died as result (n=109; average 58±2.8 years) — young subgroup (n=19, 18–44 years), middle-aged (n=37, 45–59 elderly (n=53, 60–74 years); second (n=30, 49±2.3 years; autopsy material from causes unrelated COVID-19, obtained outside pandemic) people (n=10, years). Histological immunohistochemical studies carried out using primary antibodies CD3, CD4, CD68, CD163, CD138 statistical methods: Kolmogorov–Smirnov test, Student's t-test, Mann–Whitney U test Fisher test. RESULTS: All testicular samples revealed signs viral orchitis significant spermatogenesis index (in 5.9±0.2% p=0.02; middle 5.1±0.2% p=0.008; 3.6±0.1% at p=0.006) compared control (6.8±0.3%), increase number T-lymphocytes (CD3+, CD4+), macrophages (CD68+, CD163+) plasma (CD138+) interstitial tissue. In addition, (3.6±0.1% versus young, p=0.007) CD4+) was found older younger COVID-19. CONCLUSION: CD4+, CD68+, CD138+, tissue found, especially pronounced group.

Language: Английский

Intrinsic factors behind long‐COVID: II. SARS‐CoV‐2, extracellular vesicles, and neurological disorders DOI
Yousra A. El‐Maradny, Alberto Rubio‐Casillas,

Kareem I. Mohamed

et al.

Journal of Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 124(10), P. 1466 - 1485

Published: Oct. 1, 2023

Abstract With the decline in number of new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infections, World Health Organization announced end SARS‐CoV‐2 pandemic. However, repercussions this viral pandemic may remain with us for a longer period time, as it has remodeled lives humankind many ways, including social and economic. Of course, its most important on human health level. Long‐coronavirus disease (COVID) or post‐COVID is state which we do not have concrete definition, specific international classification diseases Code, clear diagnostic tools, well‐known effective cures yet. In second article from Intrinsic Factors behind long‐COVID Series, try to link symptoms their causes, starting nervous system. Extracellular vesicles (ECVs) play very complex ramified roles bodies both healthy not‐healthy individuals. ECVs facilitate entry bioactive molecules pathogens into tissues cells system across blood–brain barrier. Based size, quantity, quality cargo, are directly proportional pathological condition severity through intertwined mechanisms that evoke inflammatory immune responses typically accompanied by over variable time periods according type these symptoms.

Language: Английский

Citations

10
Neurological and Psychiatric Disorders in the COVID-19 Era DOI Creative Commons
Tommaso Ercoli, Francesco Loy, Carla Masala

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 355 - 355

Published: April 2, 2024

Over the 4 last years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has determined diffusion of disease 2019 (COVID-19) global outbreak [...].

Language: Английский

Citations

0
Characteristics of immunocompetent cells in the testicles of different age group patients with COVID-19 DOI Open Access
Grigory Demyashkin, Dmitry V. Boldyrev, Matvey Vadyukhin

et al.

Kazan medical journal, Journal Year: 2024, Volume and Issue: 105(4), P. 533 - 542

Published: July 25, 2024

BACKGROUND: There is an opinion that the new coronavirus infection COVID-19 can initiate development of a local inflammatory reaction in testicles, which leads to damage spermatogenic epithelial cells and decrease fertility patients long term. AIM: Morphofunctional assessment immunocompetent testicles with depending on age. MATERIAL AND METHODS: Based anamnestic, clinical morphological data, groups were formed, each included subgroups according age periodization World Health Organization: first group who died as result (n=109; average 58±2.8 years) — young subgroup (n=19, 18–44 years), middle-aged (n=37, 45–59 elderly (n=53, 60–74 years); second (n=30, 49±2.3 years; autopsy material from causes unrelated COVID-19, obtained outside pandemic) people (n=10, years). Histological immunohistochemical studies carried out using primary antibodies CD3, CD4, CD68, CD163, CD138 statistical methods: Kolmogorov–Smirnov test, Student's t-test, Mann–Whitney U test Fisher test. RESULTS: All testicular samples revealed signs viral orchitis significant spermatogenesis index (in 5.9±0.2% p=0.02; middle 5.1±0.2% p=0.008; 3.6±0.1% at p=0.006) compared control (6.8±0.3%), increase number T-lymphocytes (CD3+, CD4+), macrophages (CD68+, CD163+) plasma (CD138+) interstitial tissue. In addition, (3.6±0.1% versus young, p=0.007) CD4+) was found older younger COVID-19. CONCLUSION: CD4+, CD68+, CD138+, tissue found, especially pronounced group.

Language: Английский

Citations

0