Oxidative Stress Index and Peripheral Biomarkers for Schizophrenia: A Revisited Approach.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 25, 2024

Abstract Aims: Mental health issuesremain challenging due to the current diagnostic criteria based on traditional approaches. Misdiagnosis in Schizophrenia is common for various reasons, including inconsistent knowledge about patient's history, unstable and overlapping symptoms, lack of experienced professionals. Oxidative stress or redox dysregulation inflammation implicate behavioral alterations Schizophrenia. This study aims evaluate role peripheral biomarkers, particularly oxidants/antioxidants, inflammatory markers, their potential correlations with oxidative index (OSI) Methods: Multiple approaches were considered measure serum lipid profile, leukocyte indices, C-Reactive Protein (CRP), Inflammatory Paraoxonase 1 (PON1), total antioxidant/oxidant status (TAS/TOS), both schizophrenic patients healthy individuals (n=50 each group) by using standardized statistical methods. Results: Our results further validate involvement suggest applicability as a biomarker restraint, potentially yielding more accurate diagnosis Conclusion: play complementary roles, especially The may be tool accurately diagnosing other related parameters. Further studies must confirm these findings, future research larger sample size.

Language: Английский

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Oxidative Stress in Schizophrenia

Published: Jan. 1, 2024

Language: Английский

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Psychopharmacology and Biological Studies of Psychosis

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(6), P. 854 - 854

Published: May 25, 2023

In most cases, psychotic episodes occur in the course of chronic mental illnesses, e [...].

Language: Английский

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THE MECHANISM AND BIOCHEMISTRY IN OXIDATIVE STRESS A BRIEF OVERVIEW

CURRENT TRENDS IN NATURAL SCIENCES, Journal Year: 2023, Volume and Issue: 12(24), P. 84 - 96

Published: Dec. 31, 2023

This article provides a comprehensive overview of oxidative stress, emphasizing its pivotal role in human health and disease progression. Oxidative characterized by an imbalance between reactive oxygen species (ROS) antioxidative defense, leads to cellular damage exacerbates chronic diseases. Initially perceived solely as harmful, recent studies reveal ROS's dual signaling metabolic regulation. shift perspective underlines the nuanced nature redox biology, where ROS can be both beneficial detrimental. The highlights importance strategies, including enzymes like SOD, catalase, glutathione peroxidase, small molecular weight antioxidants such vitamins E C. Advancements sensor understanding have redefined focusing on need for precise diagnostic therapeutic strategies. paper underscores necessity ongoing research characterize biomarkers establish robust clinical epidemiological reference values.

Language: Английский

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Adolescent stress induces behavioral changes and hippocampal excitatory/inhibitory imbalance: involvement of redox dysregulation and mitochondrial dysfunction

Published: Aug. 2, 2023

The developing adolescent brain is highly susceptible to social experiences and environmental insults, influencing how personality traits emerge.We previously found that stress leads long-lasting behavioral changes excitatory/inhibitory (E/I) balance dysregulation in the ventral hippocampus (vHip) associated with neurodevelopmental disorders, such as schizophrenia bipolar disorder.The neurobiological mechanisms of psychiatric disorders have been linked oxidative damage reduced antioxidant capacity brain.However, impact severe stressors during adolescence, a critical period, on mitochondrial function, redox balance, their functional consequences are not completely understood.We hypothesized respiratory function homeostasis vHip affected by stress, leading electrophysiological neuropsychiatric disorders.First, we performed characterization late adolescence (postnatal day, PND 47 -50), including naïve animals exposed from 31 until 40 (10 days footshock 3 restraint sessions) assessing sociability (social interaction test) cognition (novel-object recognition test).Then, uncovered E/I analyzing activity glutamate pyramidal neurons, number parvalbumin (PV)-containing GABAergic interneurons possible association stress.To address dynamic homeostasis, high-resolution respirometry, DHE staining, MitoSox™ AmplexRed ® assays one (PND 41) ten 51) after protocol.Also, evaluated glutathione (GSH) disulfide (GSSG) levels at 51.Finally, assess genome-wide transcriptomic signature stressed performing bulk RNAsequencing following tests.One week adolescent-stressed exhibited: (1) loss cognitive impairment; (2) enhanced neuron activity; (3) reduction PV-positive cells perineuronal nets.These were an increased marker vHip, which was co-localized PV interneurons.By respirometry analysis, impacted uncoupled efficiency phosphorylation 51).In addition, displayed revealed molecular analysis.GSSG serum negatively correlated performance, indicating GSH oxidized ROS conditions, may affect phenotype.In another cohort animals, identified three cluster subgroups principal component analysis assessment: higher-behavioral z-score (HBZ), lower-behavioral (LBZ), animals.Genes encoding subunits complexes significantly down-regulated both LBZ (Cox7c) (Coa5), while Txnip gene encoded thioredoxin-interacting protein up-regulated performance.Our results identify genes distinct phenotypes highlight negative regulation, partially imbalance abnormalities.

Language: Английский

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