Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2617 - 2617

Published: Sept. 23, 2023

Among the high prevalence of cerebrovascular diseases nowadays, acute ischemic stroke stands out, representing a significant worldwide health issue with important socio-economic implications. Prompt diagnosis and intervention are milestones for management this multifaceted pathology, making understanding various stroke-onset symptoms crucial. A key role in is emphasizing essential multi-disciplinary team, therefore, increasing efficiency recognition treatment. Neuroimaging neuroradiology have evolved dramatically over years, multiple approaches that provide higher morphological aspects as well timely cerebral artery occlusions effective therapy planning. Regarding treatment matter, pharmacological approach, particularly fibrinolytic therapy, has its merits challenges. Endovascular thrombectomy, game-changer management, witnessed advances, technologies like stent retrievers aspiration catheters playing pivotal roles. For select patients, combining endovascular strategies offers evidence-backed benefits. The aim our comprehensive study on to efficiently compare current therapies, recognize novel possibilities from literature, describe state art interdisciplinary approach stroke. As we aspire holistic patient emphasis not just medical but also physical mental health, community engagement. future holds promising innovations, artificial intelligence poised reshape diagnostics treatments. Bridging gap between groundbreaking research clinical practice remains challenge, urging continuous collaboration research.

Language: Английский

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The Role of Sensory Impairments on Recovery and Rehabilitation After Stroke

Current Neurology and Neuroscience Reports, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

The current review aims to address critical gaps in the field of stroke rehabilitation related sensory impairment. Here, we examine role and importance sensation throughout recovery neural injury, potential clinical experimental approaches for improving function, mechanism-based theories that may facilitate design sensory-based somatosensation. Recently, neurorehabilitation has shifted using more quantitative sensitive measures accurately capture function other neurological populations. These have laid groundwork understanding how impairments impact overall after stroke. However, there is less consensus on which interventions are effective remediating with vary from re-training, robotics, stimulation interventions. Current evidence found motor systems interdependent, but commonly independent trajectories Therefore, it imperative assess somatosensory order guide outcomes trajectory. Overall, considerable work still remains, as limited purported mechanisms recovery, promising early-stage focuses training, a evidence-practice gap rehabilitation.

Language: Английский

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Bibliometric and visualized analysis of the application of artificial intelligence in stroke

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 11, 2024

Stroke stands as a prominent cause of mortality and disability worldwide, posing major public health concern. Recent years have witnessed rapid advancements in artificial intelligence (AI). Studies explored the utilization AI imaging analysis, assistive rehabilitation, treatment, clinical decision-making, outcome risk prediction concerning stroke. However, there is still lack systematic bibliometric analysis to discern current research status, hotspots, possible future development trends applications

Language: Английский

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The independence of impairments in proprioception and visuomotor adaptation after stroke

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 18, 2024

Abstract Background Proprioceptive impairments are common after stroke and associated with worse motor recovery poor rehabilitation outcomes. Motor learning may also be an important factor in recovery, some evidence healthy adults suggests that reduced proprioceptive function is reductions learning. It unclear how proprioception relate stroke. Here we used robotics a traditional clinical assessment to examine the link between type of known as visuomotor adaptation. Methods We recruited participants first-time unilateral controls matched for overall age sex. more affected arm were assessed using robotic position- (APM) movement-matching (AMM) tasks. scale (Thumb Localization Test; TLT). Visuomotor adaptation was task systematically rotated hand cursor feedback during reaching movements (VMR). quantified much adapted disturbance many trials they took adapt same levels controls. Spearman’s rho relationship proprioception, TLT, Data from identify who impaired The independence examined Fisher’s exact tests. Results Impairments (58.3%) (52.1%) (n = 48; 2.10% acute, 70.8% subacute, 27.1% chronic stroke). Performance on APM task, AMM TLT scores correlated weakly measures tests demonstrated independent our sample. Conclusion Our results suggest Further studies needed understand factors influence learning, other outcomes throughout recovery.

Language: Английский

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A pilot study for self-guided, active robotic training of proprioception of the upper limb in chronic stroke

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 7, 2024

Background Proprioceptive impairments of the upper limb are common after stroke. These not typically addressed during assessment or rehabilitation. Currently, most robotic paradigms for rehabilitative training have focused solely on improving motor function targeted proprioception in individuals with combined use visual feedback. Our goal was to design a paradigm that directly targets limb, while minimizing reliance other sensory information improve sensorimotor Methods In this pilot study, 5 stroke participants and age-matched controls were tested single-day proprioceptive paradigm. Here, used joystick their less-affected arm send commands KINARM exoskeleton would passively move more-affected arm. To complete passive reaching task, relied only feedback from given knowledge results each trial. Sensorimotor measured pre- post-training via measures (Visually Guided Reaching (VGR)) position sense (Arm Position Matching (APM)). quantified as Task Score, which incorporated multiple task-relevant parameters both VGR APM. Changes performance due calculated difference APM within control groups. Results We found significant improvements pre-training (p < 0.001, CLES = 100) observed 0.87, 80). changes (Posture Speed, Reaction Time, Initial Direction Angle, Min-Max Speed Difference, Movement Time) (Contraction/Expansion Ratio_x Shift_y) parameters. Conclusions novel resulted aspects chronic This study demonstrates feasibility Future studies aim examine multi-day longer-term impacts function.

Language: Английский

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Robot-aided assessment and associated brain lesions of impaired ankle proprioception in chronic stroke

Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)

Published: June 24, 2024

Abstract Background Impaired ankle proprioception strongly predicts balance dysfunction in chronic stroke. However, only sparse data on position sense and no systematic motion stroke are available. Moreover, the lesion sites underlying impaired have not been comprehensively delineated. Using robotic technology, this study quantified proprioceptive deficits post-stroke determined associated brain lesions. Methods Twelve adults with 13 neurotypical participated. A robot passively plantarflexed a participant’s to two distinct positions or at velocities. Participants subsequently indicated which of movements was further/faster. Based stimulus-response data, psychometric just-noticeable-difference (JND) thresholds intervals uncertainty (IU) were derived as measures bias precision. To determine group differences, Welch’s t-test Wilcoxon-Mann-Whitney test performed for JND threshold IU, respectively. Voxel-based subtraction analysis identified lesions observed Results 83% exhibited abnormalities either sense, both. IU significantly elevated compared control (Position sense: + 77% JND, 148% IU; Motion +153% 78% IU). Adults both had parietal, frontal, temporoparietal regions. Conclusions This is first document magnitude frequency impairment Proprioceptive characterized by increased perceiving position/motion. Furthermore, cortical senses largely overlapping.

Language: Английский

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A Novel Wrist Device for Characterizing the Components of Proprioceptive Acuity

Published: July 15, 2024

Proprioception is important in human motor control but can be impaired by neurological disease. Unfortunately, our understanding of proprioceptive deficit very limited, especially for joints such as the wrist. To address this gap, we have constructed a robotic testbed designed to measure different aspects acuity at wrist during pronation/supination. Utilizing testbed, conducted battery psychometric tests with N = 11 neurologically-intact individuals validate robot's ability quantify position, velocity, and torque sensing capabilities, both actively passively. Overall, findings demonstrate that capture metrics healthy participants, passive active velocity senses are individuals. In future, plan expand device test other degrees freedom, implement living stroke help better inform personalized treatment faster recovery.

Language: Английский

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Robot-aided Assessment and Associated Brain Lesions of Impaired Ankle Proprioception in Chronic Stroke

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 8, 2023

Abstract Background Impaired ankle proprioception strongly predicts balance dysfunction in chronic stroke. However, only sparse data on position sense and no systematic motion stroke are available. Moreover, the lesion sites underlying impaired have not been comprehensively delineated. Using robotic technology, this study quantified proprioceptive deficits post-stroke determined associated brain lesions. Methods Twelve adults with 13 neurotypical participated. A robot passively plantarflexed a participant’s to two distinct positions or at velocities. Participants subsequently indicated which of movements was further/faster. Based stimulus-response data, psychometric just-noticeable-difference (JND) thresholds intervals uncertainty (IU) were derived as measures bias precision. To determine group differences, Welch’s t-test Wilcoxon-Mann-Whitney test performed for JND threshold IU, respectively. Voxel-based subtraction analysis identified lesions observed Results 83% exhibited abnormalities either sense, both. IU significantly elevated compared control (Position sense: + 77% JND, 148% IU; Motion +153% 78% IU). Lesions parietal, frontal, temporoparietal regions both senses, medial/lateral occipital cortex exclusively linked temporal pole sense. Conclusions This is first document prevalence magnitude impairment Proprioceptive characterized by increased perceiving position/motion. Associated cortical senses largely overlapping, but independently dysfunction.

Language: Английский

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